Navigation Links
Lead in bone associated with increased risk of death from cardiovascular disease in men
Date:9/9/2009

Boston, MA -- Growing evidence shows that exposure to lead in the environment is associated with cardiovascular disease, including increased risk of hypertension. However, those studies have looked at lead concentrations in blood, not bone lead, a better indicator of cumulative lead exposure over time. In a new study, researchers at the Harvard School of Public Health (HSPH) and the University of Michigan School of Public Health found that bone lead was associated with a higher risk of death from all causes, particularly from cardiovascular disease. It is the first study to analyze the association between bone lead and mortality.

The study appears online on September 8, 2009, on the website of the journal Circulation and will appear in a later print edition.

"The findings with bone lead are dramatic. It is the first time we have had a biomarker of cumulative exposure to lead and the strong findings suggest that, even in an era when current exposures are low, past exposures to lead represent an important predictor of cardiovascular death, with important public health implications worldwide," said Marc Weisskopf, assistant professor of environmental and occupational epidemiology at HSPH and lead author of the study.

Air pollution was the main source of lead in the environment in recent years, though it has been decreasing since leaded gasoline was banned in the U.S. in the mid-1990s. Most of the lead circulating in the body is deposited in bone and remains there for years, unlike blood lead, which has a half life of about 30 days. Since adverse effects from lead on the cardiovascular system would be expected to show up over time, the researchers expected that bone lead would be a better marker of chronic toxicity.

The researchers, led by Weisskopf and senior author Howard Hu, professor of environmental health, epidemiology and internal medicine at the University of Michigan School of Public Health, analyzed data from 868 participants in the Department of Veterans Affairs Normative Aging Study, a study of aging in men that began in 1963. Blood lead and bone leadanalyzed using X-ray fluorescencewere measured for each of the participants. The results showed that the risk of death from cardiovascular disease was almost six times higher in men with the highest levels of bone lead compared to men with the lowest levels. The risk of death from all causes was 2.5 times higher in men with the highest levels of lead compared to those with the lowest levels. The results appeared independent of age, smoking, education, race, alcohol, physical activity, BMI, high density lipoprotein or total cholesterol levels, hypertension or diabetes.

There are a number of mechanisms, such as increased oxidative stress, by which lead exposure may result in cardiovascular mortality, say the authors. They also note that, in addition to high blood pressure, exposure to lead has been associated with widened pulse-pressure (an indicator of arterial stiffening) and heart disease.

Given that bone lead may be a better biomarker of cumulative lead exposure than blood lead, it may be the best predictor of chronic disease from exposure to lead in the environment. "In addition to spurring further public health measures to reduce exposure to lead and to begin monitoring for cumulative exposure, mechanistic and clinical research is needed to determine if opportunities exist to conduct targeted screening and treatment that can further reduce the burden of cardiovascular disease for the millions of adults who have had years of elevated lead exposure in the past," said Hu.


'/>"/>

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-3952
Harvard School of Public Health
Source:Eurekalert

Related medicine news :

1. Associated Press Cites Mexico as Example of H1N1 Success
2. Resident Duty-Hour Reform Associated With Increased Complication Rate
3. Chemotherapy for breast cancer is associated with disruption of sleep-wake rhythm in women
4. Workplace bullying is associated with sleep disturbances
5. Family Circle Magazine Features AmLactin(R) in Article on Managing Dry Skin Associated With Keratosis Pilaris
6. Upsher-Smith Launches New Website for Divigel(R), a Bioidentical and FDA-Approved Hormone Therapy for Moderate to Severe Hot Flashes, Including Night Sweats, Associated with Menopause
7. HerbalScience Research Identifies Key Bioactives in Nettle Extract That Inhibit Inflammation Associated with Seasonal Allergies
8. Neck surgery for cervical spine disorders found to alleviate associated headaches
9. Neck Surgery for Cervical Spine Disorders Found to Alleviate Associated Headaches
10. Ongoing Study Shows That Endovascular Therapy is Associated With High Cure Rate for Childhood Eye Cancer
11. Genetic Variation Associated With Survival Advantage in African Americans With HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2017)... California (PRWEB) , ... September 23, 2017 , ... ... discusses the behavioral approach to fighting obesity of Robert Kushner, director of Chicago’s ... to weight loss and promoting healthier habits, the article notes that the center ...
(Date:9/22/2017)... , ... September 22, 2017 , ... MEDIA OPPORTUNITY: , ... rally to interview citizens on why they are rallying against Mayo Clinic. Specifically, media ... this effort against Dr. Noseworthy’s (CEO) decision to close the Albert Lea hospital. , ...
(Date:9/22/2017)... TX (PRWEB) , ... September 22, 2017 , ... Fenwick ... to strengthen the communities they serve as part of the nationally recognized ‘Agents of ... working closely with nonprofit organizations and community leaders to seek out those who most ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... in Pennsylvania, is pleased to offer in-home and online newborn sleep consultations ... deprivation has on the body,” says company owner Courtney Zentz, a pediatric sleep ...
(Date:9/22/2017)... ... September 22, 2017 , ... Pullano Law Offices, a Chicago personal ... has been selected to serve as President of the North Suburban Bar Association ... and Award Dinner hosted by the NSBA at the North Shore Country Club in ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... 7, 2017 NuvoAir (formerly called Pond ... today a partnership with Novartis Pharma AG to distribute NuvoAir,s ... as the leading mobile spirometry platform and Novartis, commitment to ... ... ...
(Date:9/6/2017)... 2017  Robert G. Szewc, M.D., is recognized by ... recognition of his contributions to the Medical field.      ... at the practice of Kidney and Hypertension Specialists, which ... hypertension solutions. He has worked in this position since ... as well as expertise in kidneys, hypertension, chronic disease ...
(Date:9/6/2017)... Del. , Sept. 6, 2017 NeuroRx, a ... Acute Suicidal Ideation and Behavior (ASIB), has been granted Fast ... its sequential therapy of NRX-100 (ketamine HCl) followed by NRX-101 ... in a pivotal trial of this sequential therapy targeting patients ... depression. 1 ...
Breaking Medicine Technology: