Navigation Links
Lead blood levels may increase smokers' risk for kidney cancer
Date:1/23/2012

Higher than normal levels of lead in the blood may signal a risk two times higher than average of developing renal cell carcinoma in smokers, according to medical researchers.

"Past studies (in cadavers) have shown that, compared with kidneys from individuals without cancer, kidneys from individuals with cancer have higher lead levels," said Emily B. Southard, medical student at Penn State College of Medicine. "But prior to this study, the identification of higher lead in blood as a risk factor among healthy individuals before they develop kidney cancer had not been shown."

Southard, working with Robin Taylor Wilson, associate professor of public health sciences at the College of Medicine, analyzed data collected from the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study to measure levels of blood lead, calcium and vitamin D in stored blood donated by healthy individuals several years before renal cell carcinoma ever developed.

According to the National Institutes of Health, renal cell carcinoma is the most common type of kidney cancer in adults, accounting for 92 percent of kidney cancers. The National Cancer Institute of the NIH predicted that there would be about 56,000 new cases of RCC in 2011 and has reported that nearly 300,000 people in the United States are living with kidney cancer today.

In previous studies involving animals, researchers had found an inverse correlation between the amount of lead retained in the body and the amount of calcium in the diet. This supports the hypothesis that higher calcium levels in the body can reduce lead retention. While Southard and Wilson also found that levels of calcium were higher in men who had a lower risk of kidney cancer, there was not a strong correlation between blood levels of lead and blood level of calcium or 25-hyrdoxyvitamin D. Therefore, they could not conclude that calcium or vitamin D levels had an influence on the risk observed related to blood lead levels.

Southard and Wilson looked at whether the subjects had ever been in a "high-risk occupation," which would expose the subject to more lead than an average person -- such as mining, asbestos fabric manufacture or oil refining.

"There were no significant differences in occupational history or smoking history between cases and controls in our study that would sufficiently explain the association we observed," the researchers reported online in Cancer Epidemiology, Biomarkers and Prevention.

The ATBC study consisted of nearly 30,000 Finnish male smokers between the ages of 50 and 69 years, enrolled from 1985 to 1988. The study was initially conducted to study lung cancer prevention. This study collected blood samples periodically for over two decades. Finland has a cancer registry that tracks patients, making it easier to follow up with patients after diagnosis than it is in the United States.

Southard, Wilson and colleagues looked at a cohort within the ATBC study that included 154 renal cell carcinoma cases, diagnosed after the initial blood collection, and 308 controls. Notably, Southard and Wilson found that among renal cancer cases alone, those with higher blood levels of calcium and vitamin D had a longer period of time before they developed cancer, as measured from blood when they first enrolled in the study as healthy individuals.

"This association suggests that vitamin D and calcium biomarkers may be important clues that can lead us to the early diagnosis of cancer," said Wilson. This is important because there are currently no available screening tests for kidney cancer.

"Studies have shown that people with kidney cancer have higher average lead levels in their kidney tissue, compared with people without kidney cancer," said Southard. "Prior to our study, this was only shown in cadavers and not in living people. Now we have shown that elevated blood lead levels put smokers at higher risk for renal cell carcinoma."

Further work is in progress by Penn State investigators to identify risks among women and non-smokers to find early detection biomarkers.


'/>"/>

Contact: Victoria M. Indivero
vmi1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. Bowel disease link to blood clots
3. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
7. Bilberry Seems to Act Against Blood Sugar
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
10. NHLBI, CDC launch surveillance and research program for inherited blood diseases
11. IOM report declares high blood pressure a neglected disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... , ... February 13, 2016 , ... The producers of ... of American businesses. , The increasingly modern world of instantaneous consumption proves very ... non-renewable energy sources such as oil and coal, which pollutes our air, water, and ...
(Date:2/13/2016)... ... February 13, 2016 , ... In the early or “honeymoon” stage ... to perfection, go out of their way to be romantic, and may exaggerate a ... look at any online dating profile. , A recent study from Queendom.com ...
(Date:2/12/2016)... ... , ... The law firm of Morrow, Morrow, Ryan & Bassett is offering ... scholarships is to encourage applicants to pursue a degree in their field of study ... , “We have available jobs in St. Landry and Evangeline Parishes that can ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, ... ... in Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, ... burner issue in the life cycle of pharmaceutical products, garnering increased attention from ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a ... closed for the ISE Southeast Awards 2016. Finalists and winners of the ISE® ... Southeast Executive Forum and Awards Gala on March 15, 2016 at the Westin ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- Governor Andrew M. Cuomo today announced a major expansion ... Western New York . This announcement, made ... includes a major expansion of Athenex,s North American headquarters ... , as well as the creation of a state-of-the-art, ... . The combined projects are expected to yield ...
(Date:2/11/2016)... Feb. 11, 2016 Potrero Medical, Inc., the developer ... announce the appointment of George M. Rapier, III , ... Antonio, TX , WellMed is one of the nation,s ... and HMO members in Texas and ... out of his own internal medicine practice, he has been ...
(Date:2/11/2016)... Ga. , Feb. 11, 2016  MiMedx Group, ... company utilizing human amniotic membrane and other birth tissues, ... platforms to develop and market advanced products and therapies, ... Capital Markets, 2016 Global Healthcare Conference in ... Chairman and CEO, Michael J. Senken , Chief ...
Breaking Medicine Technology: