Navigation Links
Lawson research suggests breast cancer cells have discerning tastes
Date:8/7/2012

LONDON, ON If detected early, most cases of breast cancer are curable. But if the tumour has metastasized or spread to a site outside of the breast cure rates decline. A team of researchers from Lawson Health Research Institute and Western University have received $449,733 from the Canadian Breast Cancer Foundation Ontario Region to study a rare subpopulation of tumour cells called cancer stem cells (CSCs) in hopes of uncovering the mystery behind metastasis.

Approximately 90 per cent of all breast cancer deaths are caused by metastasis. One reason is that the escaped cells are hard to find until they have grown big. "We have become quite good at treating breast cancer if the tumour is localized to the breast," says Dr. Alison Allan, researcher at the London Regional Cancer Program, London Health Sciences Centre. "However, once cells have metastasized they are very difficult to find until they grow to a certain size and start to interfere with the function of an organ."

Dr. Allan's lab was the first in the world to demonstrate that CSCs from the breast are more metastatic than other cells. "We believe these cells are the bad guys they are the really aggressive cells and the ones driving tumour growth."

Clinical observation has shown that breast cancer cells preferentially spread to the lymph nodes, lung, liver, bone, and brain. Other primary cancers have different preferential sites of metastasis (i.e., prostate cancer usually metastasizes to the bone, and colorectal cancer to the liver). Dr. Allan and her lab are focusing their research on CSCs in order to discover why these cells favour these particular sites over others.

One of the theories to explain the spread of tumours is the "seed and soil" theory. It suggests that organ-specific patterns can be accounted for by the needs of the cancer cell (the seed) for a specific environment provided by the organ (the soil) in order to initiate and maintain growth. Dr. Allan likens it to the seeds of a flower or dandelion: "When you blow on a dandelion the seeds scatter; however, they don't grow everywhere they've landed. They need a congenial soil in which to grow. We want to understand what conditions are necessary for metastasis and to decipher which factors are contributed by cancer cells and which are contributed by the different organs or sites."

Their preliminary work has found that breast CSCs tend to migrate to the lung so Dr. Allan's lab is investigating the factors in this micro environment that are contributing to these cells wanting to be there. "We hope that if we can target these individual factors and remove them from the microenvironment, we might be able to reduce the metastatic capacity of the cells," says Dr. Allan.


'/>"/>
Contact: Julia Capaldi
julia.capaldi@lawsonresearch.com
519-685-8500 x75616
Lawson Health Research Institute
Source:Eurekalert

Related medicine news :

1. Lawson researcher receives 1 of first-ever Pfizer Psychiatry Research Awards
2. Clemson researcher awarded nearly $245,000 to study automation trust and dependence
3. GW Researcher finds depressive symptoms and suicidal thoughts in former finasteride users
4. Healthcare researchers recognized at SingHealth Duke-NUS Scientific Congress 2012
5. Northwestern researchers investigate treatment for tumor cells in spinal fluid
6. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
7. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
8. MDC researchers develop new approach to treat acute liver failure
9. Breast Cancer Charity Overstates Value of Mammograms: Researchers
10. Boston University researchers expand synthetic biologys toolkit
11. Multiple husbands serve as child support and life insurance in some cultures says MU researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to ... Fortunately, an inventor from Austin, Texas, has identified a solution. , She developed a ... or restricted lighting. As such, it eliminates the need to turn on a light ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/23/2017)... 22, 2017 Janssen Biotech, Inc. (Janssen) announced ... from the U.S. Food and Drug Administration (FDA) for ... for the treatment of moderately to severely active rheumatoid ... data are needed to further evaluate the safety of ... RA. "We ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
Breaking Medicine Technology: