Navigation Links
Lawson research suggests breast cancer cells have discerning tastes
Date:8/7/2012

LONDON, ON If detected early, most cases of breast cancer are curable. But if the tumour has metastasized or spread to a site outside of the breast cure rates decline. A team of researchers from Lawson Health Research Institute and Western University have received $449,733 from the Canadian Breast Cancer Foundation Ontario Region to study a rare subpopulation of tumour cells called cancer stem cells (CSCs) in hopes of uncovering the mystery behind metastasis.

Approximately 90 per cent of all breast cancer deaths are caused by metastasis. One reason is that the escaped cells are hard to find until they have grown big. "We have become quite good at treating breast cancer if the tumour is localized to the breast," says Dr. Alison Allan, researcher at the London Regional Cancer Program, London Health Sciences Centre. "However, once cells have metastasized they are very difficult to find until they grow to a certain size and start to interfere with the function of an organ."

Dr. Allan's lab was the first in the world to demonstrate that CSCs from the breast are more metastatic than other cells. "We believe these cells are the bad guys they are the really aggressive cells and the ones driving tumour growth."

Clinical observation has shown that breast cancer cells preferentially spread to the lymph nodes, lung, liver, bone, and brain. Other primary cancers have different preferential sites of metastasis (i.e., prostate cancer usually metastasizes to the bone, and colorectal cancer to the liver). Dr. Allan and her lab are focusing their research on CSCs in order to discover why these cells favour these particular sites over others.

One of the theories to explain the spread of tumours is the "seed and soil" theory. It suggests that organ-specific patterns can be accounted for by the needs of the cancer cell (the seed) for a specific environment provided by the organ (the soil) in order to initiate and maintain growth. Dr. Allan likens it to the seeds of a flower or dandelion: "When you blow on a dandelion the seeds scatter; however, they don't grow everywhere they've landed. They need a congenial soil in which to grow. We want to understand what conditions are necessary for metastasis and to decipher which factors are contributed by cancer cells and which are contributed by the different organs or sites."

Their preliminary work has found that breast CSCs tend to migrate to the lung so Dr. Allan's lab is investigating the factors in this micro environment that are contributing to these cells wanting to be there. "We hope that if we can target these individual factors and remove them from the microenvironment, we might be able to reduce the metastatic capacity of the cells," says Dr. Allan.


'/>"/>
Contact: Julia Capaldi
julia.capaldi@lawsonresearch.com
519-685-8500 x75616
Lawson Health Research Institute
Source:Eurekalert

Related medicine news :

1. Lawson researcher receives 1 of first-ever Pfizer Psychiatry Research Awards
2. Clemson researcher awarded nearly $245,000 to study automation trust and dependence
3. GW Researcher finds depressive symptoms and suicidal thoughts in former finasteride users
4. Healthcare researchers recognized at SingHealth Duke-NUS Scientific Congress 2012
5. Northwestern researchers investigate treatment for tumor cells in spinal fluid
6. Moffitt Cancer Center researcher & colleagues test new drug for patients with neuroendocrine tumors
7. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
8. MDC researchers develop new approach to treat acute liver failure
9. Breast Cancer Charity Overstates Value of Mammograms: Researchers
10. Boston University researchers expand synthetic biologys toolkit
11. Multiple husbands serve as child support and life insurance in some cultures says MU researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate ... in Latin America . ... ... ... ...
Breaking Medicine Technology: