Navigation Links
Lauren Sciences LLC awarded second Michael J. Fox Foundation grant to further develop V-Smart™ Therapeutic for Parkinson's disease
Date:6/24/2013

New York, N.Y., June 25, 2013 -- Lauren Sciences LLC, a privately-held biotechnology company continuing development of its novel V-Smart platform technology, announced today the award of a second grant by The Michael J. Fox Foundation for Parkinson's Research (MJFF). The company recently completed the first stage of developing V-Smart-based therapeutics for the treatment of Parkinson's disease (PD), which was funded by MJFF, whereby it demonstrated targeted delivery of GDNF (glial-derived neurotrophic factor) to the substantia nigra and the striatum, brain regions in which neurons degenerate during the course of PD. Targeted delivery of GDNF to these brain regions was achieved by systemic administration of the company's V-Smart nanovesicles that were customized for GDNF delivery. The new MJFF grant has been awarded to investigate efficacy of the V-Smart vesicles in a PD animal model.

"We thank The Michael J. Fox Foundation for their second award to us," said Susan Rosenbaum, J.D., Chairman and Chief Executive Officer of Lauren Sciences. "This new MJFF grant has been awarded following the success of our Parkinson's disease project over the past year, and provides recognition of our innovative V-Smart drug delivery system and its potential to transform the treatment of Parkinson's disease with an effective therapeutic that overcomes the historical challenge of developing drugs that cross the blood brain barrier."

"The delivery method of trophic factors continues to be a challenge in reaching the regions of the brain where neuroprotection and repair is needed," said Jamie Eberling, Ph.D., Senior Associate Director of Research Programs at MJFF. "We are looking forward to seeing if V-Smart is proven effective in the delivery of GDNF as a potential disease-modifying therapy for Parkinson's disease."

"Optimized V-Smart vesicles formulated with GDNF have promise as a new treatment for patients," said Irwin Hollander, Ph.D., Vice President, Research and Development, Lauren Sciences. "We hope it will be able to stop progression of, or reverse, Parkinson's disease, unlike other drugs that provide merely symptomatic relief. It is anticipated that the successful outcome of efficacy studies of our GDNF-loaded V-Smart vesicles in Parkinson's pre-clinical models could lead to future clinical studies in Parkinson's disease patients."

"Our latest studies demonstrate that the novel V-Smart nanovesicles can encapsulate GDNF, cross the BBB and release the encapsulated GDNF in areas of the brain affected by Parkinson's," said Eliahu Heldman, Ph.D., Chief Scientific Officer of Lauren Sciences. "Our next goal is to demonstrate that GDNF delivered by V-Smart vesicles is capable of protecting dopaminergic neurons from degeneration in animal model of PD. The success of this project would be an important milestone in the development of GDNF-based therapy for PD that would considerably improve Parkinson's patients' lives."


'/>"/>

Contact: Susan Rosenbaum
srosenbaum@laurensciences.com
212-737-0455
Lauren Sciences LLC
Source:Eurekalert

Related medicine news :

1. Lauren Sciences independently recognized as a Technology Innovator in Drug Delivery with its V-Smart™ Platform, and selected as a Featured Company, in new report by MCD Group
2. Lauren Sciences LLCs research team at Ben-Gurion University awarded Campbell Foundation grant to develop a V-Smart therapeutic for neuro-HIV
3. esyringe® Celebrates Expansion in Life Sciences Sector
4. Abington Memorial Hospital’s Neurosciences Institute Opens Movement Disorders Center
5. NYU Professor Li named Pew Scholar in Biomedical Sciences
6. The Neurosciences Institute at Abington Memorial Hospital Opens Multiple Sclerosis Center
7. Applied Protein Sciences Acquired by IndUS Pharmaceuticals
8. Dr. Andrew Cohen of ProActive Chiropractic Recaps the 2013 Chiropractic Sports Sciences Symposium
9. Charm Sciences ROSA® One-Minute Beta-lactam Test and Charm EZ® Reader Validated by ILVO-T&V Belgium
10. KORT's Athletic Training Program at Central High School Sends Student to National Health Sciences Competition
11. Life Sciences And Analytical Reagents Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... G.A. (PRWEB) , ... February 09, 2016 , ... ... and grout cleaning and sealing company , is proud to announce that many ... their superior levels of customer service. The hard surface restoration franchises received customer ...
(Date:2/8/2016)... , ... February 08, 2016 , ... CURE Media ... has officially launched the Multiple Myeloma Heroes Awards event , which will annually ... the lives of patients with MM. The MM Heroes Awards nomination process ...
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie ... celebrates the beginning of a new charity campaign. As part of their ongoing ... Advocates (CASA). In the belief that children deserve a voice, and in the ...
(Date:2/8/2016)... New York, NY (PRWEB) , ... February 08, 2016 , ... ... handles are too much to handle, you are not alone. According to the Center ... conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some ...
(Date:2/8/2016)... ... February 08, 2016 , ... Local insurance agency Dennis ... FL area, has initiated a fundraiser for a two year old little girl ... after Christmas. To support this beautiful child who is facing life’s journey without ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... KONG , Feb. 9, 2016 Athenex, Inc. ... Athenex as Vice President of Corporate Strategy and Business Development ... MSc, MBA has joined as Senior Director and Deputy Head of Clinical ... . Simon Pedder stated, "Athenex has ... for a while. Coupled together with their unique business model ...
(Date:2/9/2016)... 2016  The Parenteral Drug Association, Inc. (PDA), ... manufacturing sterile drug products, today announced the publication ... – With link to Comparison Spreadsheet. The ... U.S. FDA, the EU, the Pharmaceutical Inspection Convention/Scheme ... --> --> PDA,s Global Sterile ...
(Date:2/8/2016)... 2016 Respiratory Devices - Medical Devices ... Devices sector report, " Respiratory Devices - Medical ... of Respiratory Devices currently in pipeline stage. ... products with comparative analysis of the products at ... players involved in the pipeline product development. It ...
Breaking Medicine Technology: