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Latest findings of Dartmouth HIV/AIDS study could turn treatment 'on its head'
Date:3/3/2011

LEBANON, NH - A clinical study of anti-HIV/AIDS medicines in the developing world is on the verge of turning "the whole treatment world on its head," according to Dartmouth pediatrician Paul Palumbo.

Palumbo, a professor of pediatric medicine at Dartmouth Medical School and executive director of the Dartmouth-affiliated DarDar Pediatric program in Dar-es-Salaam, Tanzania, unveiled the latest findings of the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT ) during the 2011 Conference on Retroviruses and Opportunistic Infections (CROI) in Boston from February 27-March 2.

Before making a formal, "late-breaking" presentation about IMPAACT's findings in Africa and India to fellow clinicians and researchers at CROI, Palumbo also shared, under confidentiality restrictions, the revelations with representatives of the World Health Organization (WHO) and of a working group of pharmaceutical leaders and officials of the U.S. State Department.

The IMPAACT P1060 trials comparing the effects of different forms of treatment on infants and young mothers began in 2006, with support from the National Institute of Allergy and Infectious Disease (NIAID) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). On October 27, 2010, an independent data and safety monitoring board (DSMB), which confidentially reviews large clinical trials on an interim basis for safety and efficacy of drugs, halted the second phase of P1060, declaring that the protease inhibitor lopinavir (LPV/r) was working so well among infants with no previous exposure to the popular anti-retroviral nevirapine (NVP) that the IMPAACT team didn't need to go further in the head-to-head trials between LPV/r and NVP to prove their point.

"We were a little surprised, anticipating the trial would run to March of 2011," Palumbo says. "We didn't expect such a superior difference."

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Contact: David A. Corriveau
david.a.corriveau@Hitchcock.org
603-653-1978
Dartmouth-Hitchcock Medical Center
Source:Eurekalert

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