Navigation Links
Latest epidemic? High cholesterol, obesity in fruit flies
Date:12/2/2009

SALT LAKE CITYHow do fruit flies get high cholesterol and become obese? The same way as people do by eating a diet that's too rich in fats.

More importantly, according to two new studies led by a University of Utah human geneticist, fruit flies use the same molecular mechanisms as humans to help maintain proper balances of cholesterol and a key form of stored fat that contributes to obesity. The findings mean that as researchers try to learn more about the genetic and biological processes through which people regulate cholesterol and fat metabolism, the humble fruit fly, also called Drosophila, can teach humans much about themselves.

"Not a lot is known about these regulatory mechanisms in people," says Carl S. Thummel, Ph.D., professor of human genetics at the U of U School of Medicine and senior author on the two studies. "But we can learn a lot by studying metabolic control in fruit flies and apply what we learn to humans."

High cholesterol and obesity, which affects an estimated 25 percent to 30 percent of the U.S. population, are linked to heart disease, diabetes, and other diseases that take huge tolls on health and add billions of dollars to the nation's medical bills. Understanding the processes that regulate cholesterol and fat in humans could be critical for addressing those health risks in people, Thummel believes.

The two studies identify a nuclear receptor, DHR96, which plays a critical role in regulating the balance or homeostasis of cholesterol and another fat molecule called triacylglycerol (TAG). Nuclear receptors are proteins that sense the presence of chemical compounds within cells. DHR96 corresponds closely to a nuclear receptor in humans, called LXR, that is known to regulate cholesterol levels.

In a study published Dec. 2 in Genes & Development, Thummel and colleagues at the U of U and two Canadian universities show that DHR96 helps regulate cholesterol in fruit flies by binding with t
'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Ovid Highlights the Latest Productivity Workflow Enhancements to Ovid Universal Search(TM) and its New Psychology Lexicon at Londons Online Information 2009 Conference
2. H1N1 News Today Examines the Swine Flu Virus From a Global Perspective; Read the Latest H1N1 Virus Vaccine & Prevention News From EIN News
3. ASAP Systems Releases Latest Version of their Passport Inventory and Asset Tracking Software with New Security Features and Administrative Tools
4. Lumension Provides Enhanced Endpoint Protection and Support for The Latest Windows Platforms
5. Leaders in the Study of Allosteric Modulation to Discuss Latest Research at Allosteric and Orthosteric Modulator Congress
6. Premier Plastic Surgery of Kansas Citys Extended Website Provides Latest Information on Male and Female Cosmetic Surgery
7. The latest on H1N1 flu from the Harvard Health Letter
8. Chronic Fatigue Syndrome and Stem Cell Therapy - Latest Research Available at CheneyResearch.com
9. Innovation and Global Clinical Trial Participation are the Focus of CenterWatch's Latest Special Report on China's Drug Development Industry
10. Reportlinker Adds H1N1 (Swine Influenza) Market Assessment (Latest Data, Company Profiles, Implications for Immunoassays and Molecular Assays) Report
11. News from the Latest Issue of Molecular Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... Atlanta, Georgia (PRWEB) May 04, 2015 Each ... the country to raise funds and awareness for breast cancer. ... Plastic Surgery will be featured as the entertainment sponsor for ... the Cure” on May 9 at the Lenox Square Mall. ... year’s Atlanta race, and to raise $1.2 million. Perimeter Plastic ...
(Date:5/4/2015)... TROY Healthcare Solutions is proud to be ... Group (RUG) Conference in Baltimore, MD from May 11 ... Group provides an opportunity for clients to gather to ... , In addition to sponsoring the event, TROY Healthcare ... RUG Conference. Attendees can stop by the TROY booth ...
(Date:5/4/2015)... May 04, 2015 In May of 2010, ... his own life. In the wake of this tragedy, Ty’s ... an organization that exposes the grim reality of bullying and ... platform for Kirk and Laura to share their story and ... from happening to another family — a mission that took ...
(Date:5/4/2015)... 04, 2015 EY today announced that ... a finalist for the EY Entrepreneur Of The Year® ... awards program recognizes entrepreneurs who demonstrate excellence and extraordinary ... personal commitment to their businesses and communities. Mr. ... of independent judges. Award winners will be announced ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 New findings ... Brain Tumor Association (ABTA) show that people diagnosed with ... and treatment options, including clinical trials, at the time ... to make difficult decisions about their course of treatment. ... of the first nationwide brain tumor volunteer network, the ...
Breaking Medicine News(10 mins):Health News:Perimeter Plastic Surgery Sponsors 2015 Susan G. Komen Greater Atlanta "Race for the Cure" 2Health News:TROY Healthcare to Exhibit at the Cerner North Atlantic Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner North Atlantic Regional User Group Conference 3Health News:WWE Legend "Rowdy" Roddy Piper Teams Up with Stand for the Silent for Timely Anti-Bullying Campaign 2Health News:WWE Legend "Rowdy" Roddy Piper Teams Up with Stand for the Silent for Timely Anti-Bullying Campaign 3Health News:EY announces Kit Check CEO and Co-founder Kevin MacDonald as an EY Entrepreneur Of The Year® 2015 Award finalist in the Greater Washington Region 2Health News:American Brain Tumor Association Poll Underscores Need for Greater Awareness and Education at Time of Diagnosis 2Health News:American Brain Tumor Association Poll Underscores Need for Greater Awareness and Education at Time of Diagnosis 3
... center, which can go awry , , WEDNESDAY, Jan. 23 ... part of the brain handles what might be called ... lead scientists closer to more effective treatments for a ... brain region is helpful because it provides insight into ...
... fingertips to tap or press a surface is essential ... use a BlackBerry or an iPhone. But researchers ... seemingly trivial action is the result of a complex ... nervous system and muscles of the hand. , ...
... 23, 2008RNA interference (RNAi) represents an innovative new strategy ... associated with disease processes, and a series of review ... RNAi and microRNAs will begin with two review papers ... of Human Gene Therapy, a peer-reviewed journal published by ...
... increased by 18.0% to ... - Medical enrollment grew by 708,000 members during 2007, - Selling, general and ... by 120 basis points during the year, - Operating cash flow exceeded $4.3 billion for the year, or 1.3 ... income, - Company reiterates ...
... KIRKLAND, Wash., Jan. 23 "A failing mind, not ... today," says Cameron,Truesdell, CEO of LTC Financial Partners, the ... be, so we,re going to give,our clients information to ... offering a free guidebook and web links to helpful ...
... for Gestiva(TM) Anticipated in Calendar 2008, Gestiva(TM), is Designated ... Prevention ... in Singleton Pregnancies, ST. LOUIS, Jan. 22 ... company that,develops, manufactures, acquires and markets technology-differentiated,branded and generic/non-branded ...
Cached Medicine News:Health News:Specific Brain Region Governs Problem-Solving Skills 2Health News:Specific Brain Region Governs Problem-Solving Skills 3Health News:What gives us fingertip dexterity? 2Health News:What gives us fingertip dexterity? 3Health News:The RNA drug revolution -- a new approach to gene therapy 2Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 2Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 3Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 4Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 5Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 6Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 7Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 8Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 9Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 10Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 11Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 12Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 13Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 14Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 15Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 16Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 17Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 18Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 19Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 20Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 21Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 22Health News:WellPoint Reports Fourth Quarter and Full Year 2007 Results 23Health News:Long Term Care Insurance Leader Offers Advice on Preventing Dementia, the Leading Cause of Care Claims 2Health News:KV Pharmaceutical Company Announces Acquisition of Rights to Gestiva(TM) 2Health News:KV Pharmaceutical Company Announces Acquisition of Rights to Gestiva(TM) 3Health News:KV Pharmaceutical Company Announces Acquisition of Rights to Gestiva(TM) 4Health News:KV Pharmaceutical Company Announces Acquisition of Rights to Gestiva(TM) 5
(Date:5/4/2015)... May 4, 2015 MEI Pharma, Inc. ... on the clinical development of novel therapies for ... effects of the Company,s investigational drug candidate ME-344 ... when combined with a tyrosine-kinase inhibitor (TKI). In ... be a potent inhibitor of mitochondrial oxidative phosphorylation ...
(Date:5/4/2015)... 4, 2015  Geneia, a company of experienced ... to improve healthcare efficiencies, today announced a first-of-its-kind ... (BNRC) use Geneia,s advanced analytics solution coupled ... quality and lower the cost of patient care. ... claims and utilization data from multiple sources to ...
(Date:5/4/2015)... 2015 Intarcia Therapeutics, Inc. ... into the newly created role of Chief ... pharmaceutical executive with world-class experience – most recently ... service at industry leaders such as Pfizer and ... range of therapeutic areas, including: cardiovascular, metabolic, oncology, ...
Breaking Medicine Technology:MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 2MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 3MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 4MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 5Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 2Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 3Intarcia Names Top Commercial Expert Michael Williams As COO; Will Chair Commercial Committee And Lead ITCA 650 Launch In U.S. 2Intarcia Names Top Commercial Expert Michael Williams As COO; Will Chair Commercial Committee And Lead ITCA 650 Launch In U.S. 3Intarcia Names Top Commercial Expert Michael Williams As COO; Will Chair Commercial Committee And Lead ITCA 650 Launch In U.S. 4
... super series slit ... Examination through small ... fundus diagnostic capability, ... potential field of ...
... Volk's super ... biomicroscopy lenses. General ... Provide unprecedented fundus ... addressing maximum potential ...
Volk indirect lenses. General diagnosis / small pupil examinations....
Volk indirect lenses. General diagnosis & treatment....
Medicine Products: