Navigation Links
Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
Date:6/16/2011

LOS ANGELES (June 15, 2011) An experimental vaccine developed by researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute targets overactive antigens in highly aggressive brain tumors and improves length of survival in newly diagnosed patients, according to new data that was presented in a poster session at the 47th Annual Meeting of the American Society of Clinical Oncology.

Patients with newly diagnosed glioblastoma multiforme, the most common and aggressive type of tumor originating in the brain, typically live only 12 to 15 months after diagnosis even with standard treatments: surgery, radiation and chemotherapy.

In this Phase I clinical trial that started in November 2006, 11 of 16 patients (69 percent) were still alive at 32 months (a median analysis time); six of 16 (38 percent) continued to be disease-free; three have gone almost four years and another three have survived more than 2.5 years with no recurrence. Median progression-free survival the time from treatment to disease recurrence (median progression-free survival) was 16.9 months.

Phase I trials generally address dosage and safety issues. To further evaluate survival statistics, a randomized, multicenter, placebo-controlled Phase II trial has been launched.

ICT-107 targets six antigens found on glioblastoma cells, three of which also are found on cancer stem cells. Those cells widely are believed to be the original source of tumor cells, enabling them to resist treatment and recur. The study revealed that all 16 patients had at least three of the targeted antigens and 75 percent had all six. Patients who had four of the antigens (MAGE-A1, AIM2, gp100 and HER2) had better immune responses and longer progression-free survival rates.

Surasak Phuphanich, MD, director of the Neuro-Oncology Program of the Department of Neurosurgery and the Department of Neurology at Cedars-Sinai, termed another finding significant: levels of a
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Rep. Giffords to Get Skull Patch in Latest Step in Recovery
2. Latest Artificial Pancreas Trials Reduce Risk of Low Blood Sugar
3. Kimmel Cancer Center at Jefferson breast cancer symposium features latest in research, treatment
4. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
5. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
6. Latest American Chemical Society podcast: Dont blame the pill for estrogen in drinking water
7. New works by UofL professors provide latest oncology reference guides
8. CTO summit and left main coronary interventions course will feature latest research and techniques
9. ASHs 52nd Annual Meeting and Exposition showcases the latest advances in the field
10. Latest American Chemical Society podcast: New water filter kills disease-causing bacteria
11. Latest Findings Back Mammograms for Women in Their 40s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... FL (PRWEB) April 26, 2015 A ... pieces of medical equipment from hospitals, surgery centers and ... of equipment will be sold including radiology, surgery, endoscopy, ... live auction will take place Tuesday, April 28th starting ... Lauderdale warehouse located at 5025 North Hiatus Rd., Sunrise, ...
(Date:4/26/2015)... New York (PRWEB) April 26, 2015 ... popular events of the season and will include a ... like purses, totes, collectibles, herbal soaps and incense, chimes, ... While browsing this year’s exciting and unique collection of ... their afternoon with Jim Martocci and the Jimmie Jazz ...
(Date:4/26/2015)... 26, 2015 Forbes Living is ... is one which is synonymous with clean beaches, sparkling office ... education are major economic influencers in the city on the ... talk show are pleased to announce the show will be ... at 3:00 PM PDT. Tune in to find out what ...
(Date:4/26/2015)... MidSouth Pain Treatment Center has ... Pain Treatment Center is a comprehensive pain management center ... Jackson, two ambulatory surgery centers in Germantown and Southaven, ... locations. , Dr. Michael Steuer , founder of ... help people, and when I discovered that I could ...
(Date:4/25/2015)... 2015 Diversified Communications has announced ... event. The Integrative Healthcare Symposium Canada, as it’s ... at the Sheraton Parkway Toronto North in Ontario. ... of the most anticipated events of the year ... program. The event aims to gather multi-disciplined practitioners ...
Breaking Medicine News(10 mins):Health News:Centurion Service Group to Auction off 1,200 Lots of Medical Equipment 2Health News:It’s Coming! The 5th Annual Tulip Festival & Mother’s Day Celebration at Honor's Haven Resort & Spa! 2Health News:Forbes Living TV Will Air in San Diego, California 2Health News:Growing Pains for MidSouth Pain Treatment Center 2Health News:Integrative Healthcare Event launching in Canada 2
... 5 in the February 2008 edition (Volume 6, Issue ... team found that the hypertension drugs diltiazem and verapamil ... with the conditions Gaucher disease, -mannosidosis, and type IIIA ... reprogramming the innate protein homeostasis machinery of the cell ...
... WASHINGTON, Feb. 4 "Congress must reject,President Bush,s Fiscal ... needs of the over 1.1 million people living with ... Director of The AIDS,Institute. "Most of the people who ... are very poor and from minority communities.,As the richest ...
... largest of its kind , , MONDAY, Feb. 4 (HealthDay News) ... link between the measles, mumps and rubella (MMR) vaccine and ... theirs was the third and largest study that has looked ... has failed to find one. , "I think it,s fabulous ...
... Gilbert Hospital is,celebrating its second anniversary. Gilbert,s first ... more than 93,000 patients and has a,staff exceeding 350. ... room wait times of less than 31 minutes, Gilbert,Hospital ... this pledge,more than 98.5 percent of the time. "There ...
... Feb. 4 - President George W.,Bush today submitted ... 2009.,In response Bruce Roberts, RPh, executive vice president ... issued the following,statement:, "President Bush,s efforts to ... health care, and even more specifically the Medicare,and ...
... a consulting firm,dedicated exclusively to improving the pharmacy ... the recent,introduction of the ARMSRx E-Audit, their upgraded ... often overlooked piece of the prescription,benefits package. The ... of opportunities in which errors can occur. Fraud, ...
Cached Medicine News:Health News:Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells 2Health News:Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells 3Health News:Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells 4Health News:President's FY09 Budget - A Disaster for Domestic AIDS: Congress Must Fund Critical Healthcare Priorities 2Health News:President's FY09 Budget - A Disaster for Domestic AIDS: Congress Must Fund Critical Healthcare Priorities 3Health News:Another Study Finds No Link Between MMR Vaccine and Autism 2Health News:Another Study Finds No Link Between MMR Vaccine and Autism 3Health News:Gilbert Hospital Turns Two 2Health News:NCPA Statement in Response to President Bush's FY 2009 Budget Proposal 2Health News:ARMSRx Tackles the New Rx Addiction -- Pharmacy Benefit Audits 2
(Date:4/24/2015)... N.C. , April 24, 2015  New ... ability of consumers to educate themselves about products ... the tools and techniques available to market researchers ... the changing consumer marketplace, it,s imperative that organizations ... to better identify market opportunities, niches and growth ...
(Date:4/24/2015)... MARLBOROUGH, Mass. , April 24, 2015 Boston ... in the Deutsche Bank 40 th Annual Healthcare Conference ... Dan Brennan , executive vice president and chief ... Relations, will participate in a 35-minute question and answer session ... a.m. ET. A live webcast of the presentation ...
(Date:4/24/2015)... , April 24, 2015  Novartis Pharmaceuticals Corporation (NPC) ... second year in a row on the annual DiversityInc Top ... its 2015 Top 50 Companies for Diversity on April 23 ... . NPC also ranked second on the DiversityInc Top ... 10 Companies for Employee Resource Groups list. ...
Breaking Medicine Technology:Pharmaceutical Industry Using New Technologies to Adjust Their Marketing and Research Approaches for Consumers 2Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4
... 2011 /PRNewswire-Asia-FirstCall/ -- American Oriental Bioengineering, Inc. (NYSE: ... company dedicated to improving health through the development, manufacture ... over the counter ("OTC") products, today announced that it ... financial results on Monday, March 14, 2011, after the ...
... China, March 4, 2011 /PRNewswire-Asia-FirstCall/ -- ... WKBT ) ("Weikang" or the "Company"), a ... (TCM), Western prescription and OTC pharmaceuticals and other health ... today announced that the Company will be presenting at ...
Cached Medicine Technology:American Oriental Bioengineering to Announce Fourth Quarter and Full Year 2010 Financial Results on March 14, 2011 2Weikang Bio-Technology to Present at Rodman & Renshaw Annual China Investment Conference 2
... Vitamin D kit is an enzymeimmunoassay for ... hydroxylated metabolites in serum or plasma. Calibrators, ... labelled 25-OH D. The diluted samples are ... with a highly specific sheep 25-OH D ...
... for the control of glucose metabolism. It ... of Langerhans as the precursor, proinsulin, which is ... are secreted in equimolar amounts into the portal ... of two polypeptide chains, the A-chain and B-chain ...
... is an integral part of the enzymatic ... II as well as the degradation of ... ACE is primarily located in endothelial cells. ... parameter for sarcoidosis and myocardial infarction but ...
... Retinol binding Proetin (RBP) is small (21kD) ... complex with pre-albumin in blood but loses ... been deliverd to the target cells. The ... the glomerulus and catabolized in the,renal tubules ...
Medicine Products: