Navigation Links
Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
Date:6/16/2011

LOS ANGELES (June 15, 2011) An experimental vaccine developed by researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute targets overactive antigens in highly aggressive brain tumors and improves length of survival in newly diagnosed patients, according to new data that was presented in a poster session at the 47th Annual Meeting of the American Society of Clinical Oncology.

Patients with newly diagnosed glioblastoma multiforme, the most common and aggressive type of tumor originating in the brain, typically live only 12 to 15 months after diagnosis even with standard treatments: surgery, radiation and chemotherapy.

In this Phase I clinical trial that started in November 2006, 11 of 16 patients (69 percent) were still alive at 32 months (a median analysis time); six of 16 (38 percent) continued to be disease-free; three have gone almost four years and another three have survived more than 2.5 years with no recurrence. Median progression-free survival the time from treatment to disease recurrence (median progression-free survival) was 16.9 months.

Phase I trials generally address dosage and safety issues. To further evaluate survival statistics, a randomized, multicenter, placebo-controlled Phase II trial has been launched.

ICT-107 targets six antigens found on glioblastoma cells, three of which also are found on cancer stem cells. Those cells widely are believed to be the original source of tumor cells, enabling them to resist treatment and recur. The study revealed that all 16 patients had at least three of the targeted antigens and 75 percent had all six. Patients who had four of the antigens (MAGE-A1, AIM2, gp100 and HER2) had better immune responses and longer progression-free survival rates.

Surasak Phuphanich, MD, director of the Neuro-Oncology Program of the Department of Neurosurgery and the Department of Neurology at Cedars-Sinai, termed another finding significant: levels of a protein associated with cancer stem cells (CD133) decreased in patients who had tumor recurrence after vaccination.

"Previous studies showed an increase in CD133 expression in patients who underwent treatment with radiation and chemotherapy. Our findings suggest that targeting antigens that are highly expressed by cancer stem cells may be a viable strategy for treating patients who have glioblastoma," he said.

Phuphanich participated in other multicenter studies that were presented at the ASCO meetings, including:

  • "A phase II study of verubulin (MPC-6827) for treatment of subjects with recurrent glioblastoma nave to treatment with bevacizumab," a poster presentation beginning at 8 a.m. on June 4.

  • "A phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma," a poster presentation beginning at 8 a.m. on June 4.

  • "A phase II study of daily afatinib (BIBW 2992) with or without temozolomide (21/28 days) in the treatment of patients with recurrent glioblastoma," an oral platform presentation beginning at 8 a.m. on June 5.

ICT-107 is a product of the biotechnology company ImmunoCellular Therapeutics, Ltd. Keith L. Black, MD, chairman of Cedars-Sinai's Department of Neurosurgery, director of the Maxine Dunitz Neurosurgical Institute and director of the Johnnie L. Cochran, Jr. Brain Tumor Center, is chairman of the company's scientific advisory board. John S. Yu, MD, vice chairman of Neurosurgery, director of the Brain Tumor Center of Excellence, director of Surgical Neuro-Oncology and surgical director of the Gamma Knife Center at Cedars-Sinai, is chief scientific officer, chairman of the board, and shareholder of ImmunoCellular. Certain rights in the dendritic cell vaccine technology and corresponding intellectual property have been exclusively licensed by Cedars-Sinai to ImmunoCellular Therapeutics, including subsequently developed versions of the vaccine investigated in this clinical study.


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Rep. Giffords to Get Skull Patch in Latest Step in Recovery
2. Latest Artificial Pancreas Trials Reduce Risk of Low Blood Sugar
3. Kimmel Cancer Center at Jefferson breast cancer symposium features latest in research, treatment
4. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
5. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
6. Latest American Chemical Society podcast: Dont blame the pill for estrogen in drinking water
7. New works by UofL professors provide latest oncology reference guides
8. CTO summit and left main coronary interventions course will feature latest research and techniques
9. ASHs 52nd Annual Meeting and Exposition showcases the latest advances in the field
10. Latest American Chemical Society podcast: New water filter kills disease-causing bacteria
11. Latest Findings Back Mammograms for Women in Their 40s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... Labs often perform the ... for lab operators and management to assess these processes with a critical eye—particularly ... unnecessary actions. , Created with the help of both internal and external ...
(Date:4/24/2017)... , ... April 24, 2017 , ... ... clearly shows that over the last decade, student well-being has seriously declined. "When ... boxes of formal education, join the Islamic State to turn the historic multi-ethnic ...
(Date:4/24/2017)... ... April 24, 2017 , ... “Learning to Use Your SPIRITUAL ... “Learning to Use Your SPIRITUAL COMPASS To Navigate Life Issues” is the creation ... former Chairman of the Board of Directors for CONTACT USA, and former member of ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... Gallardo, DDS, PA will be attending the 2017 Oral Reconstruction Foundation’s 2017 Symposium ... , The Oral Reconstruction Foundation will present its annual Global Symposium at the ...
(Date:4/24/2017)... , ... April 24, 2017 , ... ... brands, work wear distributors and International relief organizations across the globe to provide ... also offers lifestyle and work wear collections via insectshield.com . In the ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017 Research and Markets ... Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key ... to their offering. ... global pharmacogenomics market was valued at US$ 7,167.6 Mn in ... 2024, expanding at a CAGR of 5.6% from 2016 to ...
(Date:4/20/2017)... , April 20, 2017 Research ... America Pharmaceutical Contract Manufacturing Services Market Analysis By Service (Manufacturing, ... Segment Forecasts, 2014 - 2025" report to their offering. ... The Latin American ... 21.0 billion by 2025 Low drug registration cost ...
(Date:4/19/2017)... -- The Mobile X-Ray product segment is the most attractive ... forecast period Mobile X-Ray segment is the largest ... devices market, which is estimated to be valued at more ... of 7% over the forecast period. Mobile X-Ray segment is ... 100 Mn in 2017 over 2016. The segment,s revenue in ...
Breaking Medicine Technology: