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Late treatment with letrozole can reduce breast cancer recurrence risk
Date:3/10/2008

Treatment with the aromatase inhibitor letrozole (Femara) can reduce the risk of breast cancer recurrence even when initiated one to seven years after a course of tamoxifen therapy. The results of a study involving women originally in the placebo arm of an international trial of letrozole will appear in the Journal of Clinical Oncology and are receiving early online release. Among those who chose to begin letrozole treatment after the initial trial was halted, the risk that their cancer would recur was cut in half compared with those who never received letrozole. In addition, the risk of metastasis was 60 percent lower with letrozole, and the chance that a new tumor would develop in the unaffected breast dropped more than 80 percent.

It appears that estrogen-sensitive tumors remain hormone dependent and that patients survival can be improved with careful use of aromatase inhibitors, even many years after completing tamoxifen treatment, says Paul E. Goss, MD, PhD, director of Breast Cancer Research at Massachusetts General Hospital Cancer Center, who led both the current study and the earlier investigation, called the MA.17 trial. These results can be put into practice right away to improve the outlook for women treated for receptor-positive breast cancer.

Letrozole is one of a class of drugs called aromatase inhibitors that suppress the production of estrogen, which stimulates the growth of breast tumors expressing the estrogen receptor. The most widely used estrogen-blocking drug is tamoxifen, but the benefits of tamoxifen treatment drop significantly after five years, while the drugs side effects continue.

The original MA.17 trial, conducted through the National Cancer Institute of Canada, was designed to test whether letrozole could reduce tumor recurrence and increase survival in breast cancer patients who had completed five years of tamoxifen treatment. The study was halted in October 2003 a year earlier than planned whe
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Contact: Stacy Neale
sneale@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

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