Navigation Links
Late-stage ovarian cancer shows promise in two-drug phase I trial
Date:6/9/2010

INDIANAPOLIS -- The combination of decitabine and carboplatin appears to improve the outcome of women who have late-stage ovarian cancer. In an upcoming issue of the journal Cancer (online today), Indiana University researchers report four of 10 patients who participated in a phase I clinical trial had no disease progression after six months of treatment. One patient experienced complete resolution of tumor tissue for a period of time.

Advanced ovarian cancer is often diagnosed too late for treatment to be effective. Patients are often told they have virtually no chance of recovery and only months to live.

Women participating in the study were between 51 and 71, and had previously exhausted all approved treatments for ovarian cancer. They enrolled in an Indiana University Melvin and Bren Simon Cancer Center clinical trial designed to increase their sensitivity to the commonly prescribed ovarian cancer drug, platinum-based carboplatin.

Women with ovarian cancer usually survive less than one year after they become resistant to carboplatin and their cancer recurs, said co-principal investigator Daniela Matei, M.D., an associate professor of medicine at the Indiana University School of Medicine. Matei led the clinical portion of the trial.

"Carboplatin is the most efficient drug therapy for ovarian cancer," Matei said. "Unfortunately, patients with recurrent disease become resistant to the drug after one or two rounds."

Decitabine was first used to treat the study patients intravenously daily for five days followed on the eighth day with carboplatin. After a month, the regimen begins again.

Six months after the trial began, four of the patients had no disease progression. At eight-and-a-half months, seven patients were alive (and at press time, still alive). Cancerous tissue in one of the patients shrank completely.

Adverse reactions to the treatment regiments were mild, including nausea, fatigu
'/>"/>

Contact: Mary L. Hardin
mhardin@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Late-stage melanoma results in economic burden
2. Cancer Drug Safe for Late-Stage Pelvic Disease
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. Symptoms have little value for early detection of ovarian cancer
5. Symptoms Alone Dont Spot Ovarian Cancer Early
6. Ultrasound plus proteomic blood analyses may help physicians diagnose early-stage ovarian cancer
7. Abbott Receives European Regulatory Approval for New Ovarian Cancer Diagnostic Test
8. Possible ovarian cancer treatment target identified
9. Arrayit Diagnostics to Bring First Pre-Symptomatic Ovarian Cancer Blood Test to Multi-Billion Dollar Diagnostic Market in 2010
10. Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
11. How to make the best decisions when at high risk for breast or ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... 2014 Tbdress.com has recently announced ... on Nov. 28, 2014. The special offer will provide ladies ... is one of the world’s largest women’s dresses retailers, and ... People can enjoy great discounts on that day: Everything at ... delivery (for orders above $89). , People can use the ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Locks-Magnetic.com, a ... emergency doors. Moreover, all the new products are available ... The marketing manager is proud of the new emergency ... reset automatically. And customers can choose from several colors. ... Buying high quality emergency door release is not as ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its ... beach wedding dresses. “If you are looking for gorgeous ... soon as possible. Here you can enjoy 70% off ... , Holding a big marriage ceremony is the most ... beach wedding dress is uppermost priority. Ophelia, one of ...
(Date:11/23/2014)... OH (PRWEB) November 23, 2014 Wright ... on behalf of Ohio and West Virginia residents who ... other health disorders due to drinking C8 contaminated ... In Parkersburg, West Virginia. According to the C8 complaints, ... they either worked or lived in at least one ...
(Date:11/22/2014)... Cancer researchers in New York and Minnesota ... tunnels and the growth and spread of mesothelioma. ... the Surviving Mesothelioma website. , Doctors at Memorial ... have just released their study on tunneling nanotubes (TnTs), ... They found that mesothelioma cells contain many ...
Breaking Medicine News(10 mins):Health News:Tbdress.com Special Friday Shoes Sales Online Now 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 3Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 4Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2
... 14 Birner Dental Management,Services, Inc. (Nasdaq: ... its regular quarterly dividend. The Company,s board of ... cents per share of common,stock. The dividend is ... 28, 2008., Birner Dental Management Services, Inc. ...
... 14 STERIS Corporation,(NYSE: STE ) today ... the,purchase of up to $300 million in shares ... of outstanding shares as of,February 29, 2008. This ... approximately $160 million remaining. Through March,13, 2008, the ...
... Cookie Company Adds High-Fiber Line to its Selection ... of ... Cookie,Company introduced today its new line of "Nana,s Fiber Cookie Bars." ... a moist,and delicious cookie. The new Fiber Bar will complement the ...
... PHILADELPHIA A compound found in soybeans almost completely prevented ... a study published in the March 15 issue of Cancer ... , Researchers say that the amount of ... experiments was no higher than what a human would eat ...
... Famous and Everyday Moms Share Their Own Words of Wisdom, ... Win One-of-a-Kind Keepsake Book at LifesBestDays.com, CHICAGO, March 13 ... Quaker(R) Life(R) Cereal is introducing a little life,inspiration. With the ... inspiring moms to share how they make the most of ...
... Encourages ... The Community, NEW YORK, March 13 The Stay Strong ... Starts With,Us." On the heels of Terrie M. Williams, latest book, ... movement aimed to provide,a support network that encourages open dialogue about ...
Cached Medicine News:Health News:STERIS Corporation Announces New $300 Million Share Repurchase Authorization 2Health News:STERIS Corporation Announces New $300 Million Share Repurchase Authorization 3Health News:Have Your Cookie and Fiber too With Nana's Newest Cookie Bar 2Health News:Soy compound may halt spread of prostate cancer 2Health News:Soy compound may halt spread of prostate cancer 3Health News:Quaker(R) Life(R) Cereal Partners with Actress and Mom Holly Robinson Peete to Inspire Moms to Make Their Best Days Happen 2Health News:Quaker(R) Life(R) Cereal Partners with Actress and Mom Holly Robinson Peete to Inspire Moms to Make Their Best Days Happen 3Health News:The Stay Strong Foundation Launches National 'Healing Starts With US' Campaign With Celebrity Guests Denzel Washington, Ruby Dee, Mo'Nique, Terry McMillan, Rev. Al Sharpton and Others 2Health News:The Stay Strong Foundation Launches National 'Healing Starts With US' Campaign With Celebrity Guests Denzel Washington, Ruby Dee, Mo'Nique, Terry McMillan, Rev. Al Sharpton and Others 3
(Date:11/21/2014)... and VIENNA, Va. , Nov. 21, ... provider that operates in Southern California ... of remote caregiving technology. Alta will be providing the ... receiving homecare services. Logo - http://photos.prnewswire.com/prnh/20141121/160143LOGO ... the key to providing the kind of affordable 24/7 ...
(Date:11/21/2014)... , Nov. 21, 2014   Rock Creek Pharmaceuticals, ... the Company is scheduled to present at the Biotech ... CA on January 12-14, 2015. ... CEO of Rock Creek Pharmaceuticals, will present preclinical and ... agonist which exhibits anti-inflammatory pharmacological characteristics. Dr. Mullan will ...
(Date:11/21/2014)... 2014  Abaxis, Inc. (NasdaqGS: ABAX ), ... for the medical, research, and veterinary markets worldwide and ... markets in the United States , ... to acquire 100% of QCR & Trio Diagnostics Limited, ... organization. The transaction closed on November 17, 2014. ...
Breaking Medicine Technology:Alta Home Care, Inc. and BeClose Partner to Enable Seniors to Remain in Their Homes Safely and Securely 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 4Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4
... and STOCKHOLM , June 4 ... new Chief Executive Officer of BeneChill, a privately held medical ... for use by emergency response teams in the field, later ... years of experience in the pharmaceutical, biotechnology, medical device and ...
... June 4 Mylan Inc. (Nasdaq: MYL ) today ... from the U.S. Food and Drug Administration (FDA) for its Abbreviated ... 800 mg, the generic version of Pfizer,s Neurontin® Tablets for the ... be distributed by Mylan Pharmaceuticals Inc. , ...
Cached Medicine Technology:Veteran International Health Care Executive Appointed CEO of BeneChill(R) 2Mylan Receives Approval for Generic Version of Neurontin® Tablets 2
Basic external reading model....
The Marco Lensmeter 201 features internal readings for the presbyopic practitioner or those who prefer to work in subdued lighting where external readings are difficult....
... The Marco Lensmeter 101 is well ... contact lenses as well as conventional ... deluxe model with a full 90-degree ... contact lenses when used in the ...
... of macular health. Snellen charts ... 20/20). Easy to mount on ... performed in a few minutes. ... patients. Retinal vision testing without ...
Medicine Products: