Navigation Links
Laser Therapy Switches Cocaine Addiction On, Off in Rats: Study
Date:4/3/2013

WEDNESDAY, April 3 (HealthDay News) -- Rats addicted to cocaine lost the craving when researchers used laser light to stimulate a specific part of their brains.

The same team of scientists also used the laser technique to trigger new cocaine addictions in rats. They say the therapy -- which targets the prefrontal cortex of the rat brain -- could point the way to a new method of treating the addiction in humans.

"When we turn on a laser light in the prelimbic region of the prefrontal cortex, the compulsive cocaine seeking is gone," study co-researcher Dr. Antonello Bonci, adjunct professor of neurology at the University of California, San Francisco, said in a university news release.

As the researchers explained, the mammalian prefrontal cortex plays an important role in impulse control, decision-making and behavioral flexibility.

In this study, the researchers used genetic engineering to insert light-sensitive proteins called rhodopsins into nerve cells (neurons) in the rats' prefrontal cortex. Activating this brain region with a laser tuned to the rhodopsins turned the neurons on and off.

Turning on the neurons eliminated cocaine addiction while turning them off triggered addiction in the rats, according to the study published online April 3 in the journal Nature.

The findings highlight the central role the prefrontal cortex plays in cocaine addiction and also suggest a new therapy that could be immediately tested in humans, said the team of researchers from UCSF and the U.S. National Institute of Drug Abuse (NIDA).

However, human therapy would not use lasers. Instead, it would most likely rely on electromagnetic stimulation outside the scalp -- in particular, a technique called transcranial magnetic stimulation (TMS) -- to trigger a similar activation in the prefrontal cortex. TMS has been used to treat depression.

Research in animals often does not pan out in humans, experts note. However, clinical trials are now being designed to test the use of TMS in people, said Bonci, who is also scientific director of the intramural research program at NIDA and an adjunct professor at Johns Hopkins University in Baltimore.

In the clinical trials, TMS will be used a few sessions a week to stimulate the prefrontal cortex in cocaine addicts. The researchers will see if they can restore activity to the prefrontal cortex and help reduce the addicts' desire for cocaine.

An estimated 1.4 million Americans are addicted to cocaine, which was the reason for more than 482,000 emergency department visits in 2008 and is a leading cause of heart attack and stroke among people younger than 35.

Along with the health toll, cocaine has a major impact on crime, imprisonment, treatment and prevention programs, lost job productivity and lost earnings, the researchers pointed out.

More information

The U.S. National Institute on Drug Abuse has more about cocaine.

-- Robert Preidt

SOURCE: University of California, San Francisco, news release, April 3, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Slicing mitotic spindle with lasers, nanosurgeons unravel old pole-to-pole theory
2. Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
3. Ultra-short laser pulses for science and industry
4. Higher energies for laser-accelerated particles possible
5. Laser treatment improves appearance in burn scars, study shows
6. Studies Show Limits, Promise of Laser Removal of Tattoos
7. Laser-light testing of breast tumor fiber patterns helps show whose cancer is spreading
8. Beachwood Hair Clinic Announces Laser Hair Removal Services
9. No more lying about your age: Scientists can now gauge skin’s true age with new laser technique
10. FDA Clears Laser for all Critical Steps in Cataract Surgery: Center For Sight Performs the Most LENSAR Laser Procedures in U.S.
11. Long Island Counsilman Inaugurates New Laser Center
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Laser Therapy Switches Cocaine Addiction On, Off in Rats: Study
(Date:3/29/2017)... Georgia (PRWEB) , ... March 29, 2017 , ... Full ... Therilus, founder of Pet Protect Law that assists dog owners in creating ... assist new owners in taking the natural next step to protect their new companion. ...
(Date:3/29/2017)... ... 30, 2017 , ... Youth Futures International (YFI) premiered its Serve, Learn, & ... and college students who have participated in the program every summer. The 2017 ... accepting applications for enrollment. Visit http://www.ghana.yfiexperience.org to learn more. , “I ...
(Date:3/29/2017)... ... March 29, 2017 , ... Wells Pharmacy Network, a ... at the upcoming World Congress, in Hollywood Florida April 6-8, 2017. , Ben ... the visionary leader in the training of physicians, scientists, and members of the ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... webinar provides insight into the challenges employers face in trying to balance both ... managing employee benefits programs? Adding to the growing complexity, companies are finding ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... it continues developing an ANSI-approved, consensus-based American National Standard for Good Manufacturing ... publish the first ANSI-approved GMP standard for dietary supplements this spring, is ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017 Wound care devices ... healing of the wound. The industry mainly consists of ... for the treatment of wounds caused by mechanical, chemical, ... to diseases such as diabetes, skin related diseases, immunological ... Europe was the largest region in the ...
(Date:3/29/2017)... , March 29, 2017  BioSpecifics Technologies Corp. ... continues to develop collagenase based-therapies with a first ... marketed as XIAFLEX ®  in the U.S. and ... present a corporate overview at the upcoming 16 ... April 5, 2017 at 8:00 a.m. ET in ...
(Date:3/29/2017)... 29, 2017 Research and Markets has announced the ... Treated at Proton Therapy Centers & Forecast" report to their offering. ... The South Korean Proton ... market size in 2016. The Untapped Proton Therapy Market for ... in 2016. Proton Therapy plays an important role in ...
Breaking Medicine Technology: