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Largest review of management and treatment of Barrett's dysplasia and adenocarcinoma
Date:7/23/2012

The world's largest review of all the evidence on the best way of managing and treating common pre-cancerous and cancerous conditions of the oesophagus (gullet) has found that good endoscopy equipment, more endoscopic surgery, and more tissue sampling are required to improve care for patients.

The multi-national team of researchers led by Professor Janusz Jankowski of the Blizard Institute of Cell and Molecular Science at Queen Mary, University of London (UK), reviewed nearly 12,000 papers on the care and treatment of Barrett's Dysplasia and early-stage oesophageal adenocarcinoma. Their research is published online in the August issue of the medical journal Gastroenterology [1].

They used a new method of analysing the data, called the Delphi process, to reach agreement on the strength of the evidence contained within all the papers and to make recommendations for the management of patients with these conditions. This is the first time that a review of all the available research in this area has been attempted.

"In the absence of top grade evidence from large randomised clinical trials, this large systematic review, using a global consensus achieved by the Delphi voting method, allows real clarity about the best ways to treat this disease," said Professor Jankowski, who is the Sir James Black Professor of Gastrointestinal Biology and Trials.

Barrett's oesophagus [2] is a condition in which abnormal changes occur in cells lining the lower end of the gullet. It is usually caused by acid reflux and the incidence has been increasing over the past few years, with 10-20 per cent of patients with acid reflux developing Barrett's oesophagus. It can progress to become Barrett's dysplasia, when the cells become pre-cancerous, and can then develop into oesophageal adenocarcinoma (cancer). Five-year survival following a diagnosis of adenocarcinoma is less than 15 per cent, and so it is important to detect and treat the conditions
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Contact: Emma Mason (media enquiries only)
e.mason@qmul.ac.uk
Queen Mary, University of London
Source:Eurekalert

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