Navigation Links
Largest coronary artery disease study shows evidence of link between inflammation and heart disease
Date:12/4/2012

OTTAWA, December 3, 2012 The University of Ottawa Heart Institute (UOHI) participated in the largest genetic study of Coronary Artery Disease (CAD) to date. Researchers from the CARDIoGRAMplusC4D Consortium report the identification of 15 genetic regions newly associated with the disease, bringing to 46 the number of regions associated with CAD risk.

The Ruddy Canadian Cardiovascular Genetics Centre, at the Heart Institute, was the main genetic centre in Canada contributing most patient cases involved in this study and analyzing patient cases from across North America.

In this unparalleled study, published today in the prestigious scientific magazine Nature, the team identified a further 104 independent genetic variants that are very likely to be associated with the disease, enhancing our knowledge of the genetic component that causes CAD.

Researchers, including Dr. George Wells and Dr. Alexandre Stewart from the Heart Institute, used their discoveries to identify biological pathways that underlie the disease and showed that lipid metabolism and inflammation play a significant role in CAD.

CAD and its main complication, myocardial infarction (heart attack), are some of the most common causes of death in the world and approximately one in five men and one in seven women die from the disease in the UK. CAD has a strong inherited basis.

"These findings show, for the first time, clear evidence that several of the genetic risk factors for CAD function through known inflammatory pathways," said Dr. Robert Roberts, President and CEO of the Heart Institute and Director of the Ruddy Canadian Cardiovascular Genetics Centre. "This identifies a novel pathway for the prevention of heart disease and establishes molecules that can now be targeted for developing new therapies."

The Consortium spanning over 180 researchers from countries across Europe (UK, Germany, Iceland, Sweden, Finland, France, Italy, Greece), Leban
'/>"/>

Contact: Vincent Lamontagne
vlamontagne@ottawaheart.ca
613-899-6760
University of Ottawa Heart Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Smallest, Largest Fetuses at Higher Risk of Stillbirth
2. OnPage Provides Secure, Rapid Response at New England’s Largest Catholic Hospital
3. HIV suppression not as good as previously thought, largest study of viral-load blood tests show
4. Largest review of management and treatment of Barretts dysplasia and adenocarcinoma
5. Worlds largest meeting of ear, nose, and throat doctors
6. Worlds largest respiratory genetics study launches on World COPD Day
7. Coronary rehabilitation programs in Europe are underused
8. Diagnostic test shows potential to noninvasively identify significant coronary artery disease
9. Advanced CT scans accurately assess coronary blockages
10. Perceived control affects complication rates in patients with acute coronary syndrome
11. Bypass surgery improves survival for patients with diabetes and multi-vessel coronary artery disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... three months the trends for evening dresses shift ... one of the hottest styles in the next few months.” ... releases 26 A-line sweetheart evening dresses, and announces the availability ... are trying our best to help a lady to show ... affordable prices, we provide discounted delivery costs to our customers ...
(Date:12/25/2014)... The short film “Color of Honor” by young ... a true 9/11 hero, Welles Remy Crowther. It has been ... hours of Nuremberg International Short Film Festival and the 8th ... screenwriter and director Luciana Lagana plays the mother of ... husband, Gregory Graham - Graham plays a heroic ...
(Date:12/25/2014)... Helen Harris’ RP (Retinitis Pigmentosa) International ... after an 8 year battle with breast cancer. ... in her home in Woodland Hills California after an ... , As the founder and volunteer President ... and championed many of today's greatest breakthroughs in restoring ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... children with complex chronic illnesses can receive effective, less expensive ... with easy access to a team of dedicated health care ... to become seriously ill and need either hospitalization or a ... an enhanced medical home clinic at the University of Texas ...
(Date:12/25/2014)... (HealthDay News) -- Among early stage breast cancer patients ... of one percent will eventually develop leukemia as a ... The finding comes from a review of more than ... and it suggests that the risk for developing treatment-related ... previously thought. "The frequency of bone marrow cancers ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... at a premium among Afghan couples, reports say. ... do scout around for sperm donors and invariably land ... never-ending conflicts, sparked by Islamist fervour that might ... such imbalances in turn could in turn lead to ...
... scientific review of a dozen patients who have received the ... technique is safe and may be effective at staving off ... of whom live on Long Island, are in advanced stages ... when they signed on for the experimental therapy. The study ...
... employed on the moon in the not too distant ... ,According toChester Spell, an associate professor of management at ... tomorrow - or, for that matter, the space stations ... health of employees working in isolation for extended periods. ...
... Purdue University researchers have begun the first phase of human ... designed in-house. ,The drug is based on ... university. The researchers say that it may help intercept and ... of people suffer from this devastating disease and treatment options ...
... against Human Cytomegalovirus (hCMV) infection and disease was developed by ... (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences. ... viral cause of birth defects and a serious problem in ... protect against infection by the virus, estimated to be present ...
... for testing and measuring xanthones. Preliminary results from ... indicate usage of the whole mangosteen fruit as ... ,XanGo, LLC, recognized creator of the ... the whole mangosteen fruit (Garcinia mangostana) through a ...
Cached Medicine News:Health News:Afghan Couple Turn to Indian Sperm Banks for Help 2Health News:Gene Therapy for Parkinsons Disease 2Health News:Ex-IITian-designed Alzheimer's Drug's Human Clinical Trials Begin 2Health News:New Vaccine for CMV Infection 2Health News:New Vaccine for CMV Infection 3Health News:New Technique to Measure Xanthone in Mangosteen 2Health News:New Technique to Measure Xanthone in Mangosteen 3
(Date:12/24/2014)... and FARMINGTON, Conn. ... Inc. (NYSE MKT: PTN), a biopharmaceutical company developing ... diseases with significant unmet medical need and commercial ... a private placement of 2,050,000 shares of its ... 24,949,325 shares of its common stock.  Funds under ...
(Date:12/24/2014)... 23, 2014 ResMed (NYSE: RMD ) ... against Chinese medical device manufacturer BMC Medical Co., Ltd. ... BMC,s masks listed below infringe ResMed,s patents, and entered an ... in the United States : ... , Willow nasal pillows mask , iVolve full ...
(Date:12/24/2014)... , Dec. 23, 2014  The American Diabetes ... pressure target for people with diabetes and that ... high doses of statins, in keeping with recent ... by the American College of Cardiology (ACC) and ... in the most recent changes to the Association,s ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4
... to need emergency room treatment or hospitalization when ... series to examine factors impacting patient response to ... of a new study presented at the 2009 ... Allergy and Immunology (AAAAI) show dramatic reductions in ...
... At the Health Industries Council meeting on March 11, ... health and behavioral sciences at the University of ... Health, announced new findings that indicate that mortality is ... reduced spending on health care have a direct effect ...
Cached Medicine Technology:New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits 2New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits 3New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits 4Unemployment, Health Care Spending Affect Mortality 2
... Plate Shaker with Timer are designed to give ... & 384-well microplates. The on/off button, power supply ... the side of the unit. The speed knob ... for adjustment of speed from a minimum 950 ...
Microplate incubator shaker used in a variety of immunoassay and research procedures requiring microplates....
Multiparameter laser and arc lamp flow cytometer for all applications in immunology, microbiology, cell biology, pathology, hematology, lymphocyte dubset and cell analysis....
This unique system combines the analytical power of a research cytometer into a compact, truly walk away, clinical analyzer ergonomically designed to expedite sample throughput....
Medicine Products: