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Largest Study to Date Compares Cholesterol Treatment in HIV Patients & Patients Without HIV Infection
Date:3/2/2009

s obesity and hypertension also are important factors to monitor for those with HIV infection, he added.

Researchers studied 829 patients with HIV infection and 6,941 patients without HIV infection in the Kaiser Permanente health system that started cholesterol treatment during 1996 to 2005. The researchers compared changes in levels of low-density lipoprotein cholesterol (bad cholesterol) and triglycerides (another fat in the blood) after the start of cholesterol treatment in patients with and without HIV infection. They also looked at liver and muscle-related side effects of cholesterol treatments and whether the cholesterol changes in patients with HIV infection were related to the types of HIV treatments patients were taking. Among patients taking statins, LDL levels declined only 3 percent less for HIV patients; however, among patients taking gemfibrozil, triglyceride levels declined 15 percent less for HIV patients. HIV patients taking both NNRTIs and gemfibrozil had identical triglyceride declines compared with those without HIV infection. Side effects of cholesterol treatments occurred in very few patients, but patients with HIV infection did have more changes in liver and muscle enzyme levels than patients without HIV infection.

Additional researchers include Wendy Leyden, MPH, Leo Hurley, MPH, Alan S. Go, MD, Charles P. Quesenberry, Jr., Ph.D., Daniel Klein, MD, and Michael Horberg, MD, MAS, all affiliated with Kaiser Permanente in Northern California. Funding for this study was provided by GlaxoSmithKline.

About the Kaiser Permanente Division of Research (http://www.dor.kaiser.org/)

The Kaiser Permanente Division of Research conducts, publishes, and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and the society at large. It seeks to understand the de
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SOURCE Kaiser Permanente
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