Navigation Links
Large study finds genetic 'overlap' between schizophrenia, bipolar disorder
Date:9/21/2011

Knowledge about the biological origin of diseases like schizophrenia, bipolar disorder and other psychiatric conditions is critical to improving diagnosis and treatment.

In an effort to push the field forward, three UCLA researchers, along with scientists from more than 20 countries, have been taking part in one of the largest collaborative efforts in psychiatry a genome-wide study involving more than 50,000 study participants aimed at identifying which genetic variants make people susceptible to psychiatric disease.

This collaborative, the Psychiatric Genome-Wide Association Study Consortium (PGC), now reports in the current online edition of the journal Nature Genetics that it has discovered that common genetic variants contribute to a person's risk of schizophrenia and bipolar disorder.

The PGC's studies provide new molecular evidence that 11 regions on the genome are strongly associated with these diseases, including six regions not previously observed. The researchers also found that several of these DNA variations contribute to both diseases.

The findings, the researchers say, represent a significant advance in understanding the causes of these chronic, severe and debilitating disorders.

The UCLA researchers who contributed to the schizophrenia study are Roel A. Ophoff, a professor of psychiatry and human genetics and one of the founding principal investigators of the schizophrenia portion of the study; Dr. Nelson Freimer, a professor of psychiatry and director of the Center for Neurobehavioral Genetics at the Semel Institute for Neuroscience and Human Behavior at UCLA; and Rita Cantor, a professor of psychiatry and human genetics.

Schizophrenia and bipolar disorder are common and often devastating brain disorders. Some of the most prominent symptoms of schizophrenia are persistent delusions, hallucinations and cognitive problems. Bipolar disorder is characterized by severe, episodic mood swings. Both affect about 1 percent of the world's population and usually strike in late adolescence or early adulthood.

Despite the availability of treatments, these illnesses are usually chronic, and patients' response to treatment is often incomplete, leading to prolonged disability and personal suffering. Family history, which reflects genetic inheritance, is a strong risk factor for both schizophrenia and bipolar disorder, and it has generally been assumed that dozens of genes, along with environmental factors, contribute to disease risk.

In the schizophrenia study, a total of seven locations on the genome were implicated in the disease, five of which had not been identified before. When similar data from the bipolar disorder study, which ran concurrently, were combined with results from the schizophrenia study, three gene locations were identified that proved to be involved in both disorders, suggesting a "genetic overlap" between schizophrenia and bipolar disorder.

"Genetic factors play an important role in the susceptibility to develop schizophrenia," Ophoff said, "but identifying these genetic factors has been very difficult. We know that schizophrenia is not caused by a single gene that explains everything but an interplay of many genetic and non-genetic factors."

At the same time, he said, the disease itself is not uniform but manifests itself in different ways; currently, there is no objective biological marker or "sign" that can be used for diagnosis.

"This so-called heterogeneity at the genetic and clinical level is the biggest challenge for genetic studies of neuropsychiatric disorders," Ophoff said. "One way to deal with these difficulties is to increase the size of the study so there is sufficient 'power' to detect genetic effects, even amidst this clinical and genetic diversity."

The fact that even this large study resulted in a limited number of schizophrenia and bipolar genes demonstrates once again, he said, the complex nature of the disease.


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Obesity and large waist size linked to higher risk of death in African-American women
2. Large weight gains most likely for men after divorce, women after marriage
3. Largest global childhood pneumonia etiology study launched
4. Intelligence Largely Rooted in the Genes
5. Larger Dose of Zinc Lozenges May Shorten Colds
6. Worlds largest meeting of ear, nose and throat doctors
7. Largest Ob/Gyn Group Backs Annual Mammograms in 40s
8. TEMLA shows higher diagnostic yield than EBUS or EUS in largest reported series to date
9. Report finds large state disparities in progress against colorectal cancer
10. Drugs for Enlarged Prostate May Raise Risk of Aggressive Cancer
11. Vytorin Lowers Heart Disease Risk in Large Study of Kidney Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... ... America Walks , a national advocacy organization that promotes walking and ... Pittsburgh Graduate School of Public Health , has been awarded a Walking College ... around the country to participate in a four-month training program designed to strengthen local ...
(Date:5/25/2016)... ... May 25, 2016 , ... "FCPX LUT Intense allows ... your footage," said Christina Austin - CEO of Pixel Film Studios. , With ... and easily add stylish color grades to their footage. A LUT is a Lookup ...
(Date:5/25/2016)... ... May 25, 2016 , ... Consumer access to organic foods and grower access ... maker of whole grain cereals and other plant-based foods, will introduce the first consumer ... winter wheat processed by Hesco/Dakota Organic Products. , The transitional designation means the cereal ...
(Date:5/25/2016)... ... 25, 2016 , ... Stern Environmental Group , of Secaucus, New Jersey, ... as Stern’s Real Time Monitoring (RTM) Device. Stern Environmental Group will sell ... industry, colleges for use in dormitories, shelters, and nursing homes for real time bedbug ...
(Date:5/24/2016)... ... 2016 , ... Sterling Global Products is launching a Kickstarter campaign focused on ... dispenser. The campaign kick-off video is located via this link https://youtu.be/WsO4qz2odco . The ... is to raise $1,000 per day for a total of $25,000. The funds will ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 The World Health Organization ... device to include adolescents aged 13 years, and above. ... be offered for adult and adolescent males in the 14 ... . PrePex was the first male circumcision device to receive ... CEO, Eddy Horowitz said: " The expanded ...
(Date:5/23/2016)... 2016 Gamida Cell, a leader ... cancer and orphan genetic diseases, announced today it has ... from the Israel Innovation Authority (formerly the Office of ... and Industry. The mission of the Israel Innovation Authority ... including science and technology, while stimulating economic growth. ...
(Date:5/22/2016)... , May 23, 2016 ... develop its anti-fibrotic and anti-inflammatory compound DS102 in ... as in non-alcoholic steatohepatitis (NASH) patients. ... significantly sequestered in lung tissue and has bronchodilatory, ... after oral administration. The Company will publish further ...
Breaking Medicine Technology: