Navigation Links
Large-scale identification and analysis of suppressive drug interactions
Date:4/24/2014

air in Integrative Biology.

For this first test, the team worked with anti-fungal chemicals in a total of 440 drug pairs. They found that, in almost one fifth of the combinations, one drug reduced the effectiveness of the other drug. They also found that some drugs can have a greater tendency to suppress other drugs, while other drugs are more frequently suppressed. The same team published a related study in 2011, showing that for about one third of drug pairs tested the compounds increased each other's effectiveness. "If drug interactions are happening at anything approaching these rates in humans, we should be very concerned," Dr. Roth adds.

When one drug suppresses the effectiveness of another drug, "the patient is losing benefit from one or both drugs, while still potentially being exposed to their side effects," Dr. Roth adds. When a drug combination has an effect that is more than the sum of its parts, the patient might get too much of a good thing, and it is possible for drugs to intensify each other's toxicity as well.

"This methodology may also prove useful to explore positive types of drug interactions such as in personalized medicine," adds Dr. Jim Woodgett, Director of the Lunenfeld-Tanenbaum. "Diseases such as cancer rarely respond to single medications, and this new systematic technological approach may have the potential to allow rapid optimization of combination therapies," he notes. The study noted one example of a compound (Staurosporine) that was suppressed by acidity. This phenomenon is interesting in the context of cancer because the peculiar metabolism of cancer cells often makes the local tumour environment more acidic. It would be particularly exciting to find more anti-cancer compounds that were enhanced by acidity.


'/>"/>

Contact: Polly Thompson
pthompson@lunenfeld.ca
416-586-4800 x2046
Lunenfeld-Tanenbaum Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Soy may alleviate hot flashes in menopause, large-scale study finds
2. Human papillomavirus types do not replace others after large-scale vaccination
3. Study shows large-scale genomic testing feasible, impacts therapy
4. Endocrine Society calls for large-scale studies to evaluate testosterone therapy risks
5. Large-scale study shows power of pre-k
6. First identification of a strong oral carcinogen in smokeless tobacco
7. Spectrum Surgical Offers Surgical Instrument Identification Tape
8. Wayne State embarks on study to improve identification of women at high risk of stroke
9. Orange County’s New Suspect Identification Tools Meet Resistance from MacGregor & Collins Criminal Attorneys
10. Lyme Disease Prevention Begins with Proper Tick Identification and Timely Removal.
11. Adding Patient Photos to X-Rays May Cut Identification Errors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... CA (PRWEB) October 25, 2014 More ... annual President’s Circle Reception on Monday at the home ... accomplishments and hear from guest speaker Dr. Winifred Lender ... worlds. , Dr. Lender, a Santa Barbara psychologist, author ... challenges and benefits of living in the digital age. ...
(Date:10/25/2014)... QueenBeeTickets.com has a variety of tickets for online ... Bob Seger & The Silver Bullet Band tickets for ... going on sale October 25 and are expected to ... the selection of tickets for Bob Seger & The ... is touring North America beginning next month, and he ...
(Date:10/25/2014)... Oct. 24, 2014 (HealthDay News) -- Interrupting blood supply to ... reduce the risks associated with the surgery, according to a ... stop the blood supply to the heart to be able ... the heart will reduce its ability to produce energy because ... flow to another large muscle, such as an arm or ...
(Date:10/25/2014)... Current osteoporosis screening guidelines and tools fail to ... osteoporosis-related fractures, a new study says. "If ... that help us accurately predict who will suffer ... these at-risk people for preventive measures," study author ... division of general internal medicine and health services ...
(Date:10/22/2014)... October 22, 2014 On October 22, ... featuring skin diseases both fictional and real. The ... a nonprofit organization committed to advocacy and philanthropy in ... will take the opportunity to impart truth and clarity ... , There are many misconceptions about Morgellons Disease ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3
... clinical trials on a new investigational drug being developed ... been successfully completed. Completion of the initial phase ... prepared by researchers at Cardiff University,s Welsh School of ... an approved medicine have significantly improved. Approximately ...
... N.C. Millions of patients with advanced disease in palliative ... easily. But a new study from Duke University Medical ... intervention, and among those who do benefit, it doesn,t make ... just plain old room air both offer equal benefit. ...
... Reporter , THURSDAY, Sept. 2 (HealthDay News) -- An ... two hours, making only one doctor visit necessary before ... advance against a disease that kills nearly 2 million ... "This is a very important discovery," said infectious disease ...
... and a little serendipity led a Northwestern University research team ... used for gas storage and food and medical technologies. And ... first known all-natural metal-organic frameworks (MOFs) that are simple to ... the Northwestern MOFs you can pop into your mouth and ...
... Stem cells might be thought of as trunks in the ... can turn into a dazzling variety other cellskidney, brain, heart ... the capacity to turn into virtually any cell type in ... of cell therapies, the conquering of age-old diseases or even ...
... September, 2010 - Elsevier announced today the publication of ... Andropause Society (EMAS) in the journal Maturitas ... post-reproductive health of women. The statements cover the ... epilepsy, endometriosis and premature ovarian failure. Each statement ...
Cached Medicine News:Health News:First clinical trials successfully completed on potent new hepatitis C drug 2Health News:Study challenges value of oxygen therapy in end-of-life care 2Health News:Study challenges value of oxygen therapy in end-of-life care 3Health News:Experimental TB Test Called Fast and Accurate 2Health News:Experimental TB Test Called Fast and Accurate 3Health News:Edible nanostructures 2Health News:Edible nanostructures 3Health News:Study finds that cancer-causing gene crucial in stem cell development 2Health News:Study finds that cancer-causing gene crucial in stem cell development 3Health News:EMAS publishes position statements about the post-reproductive health of women 2
(Date:10/22/2014)... , Oct. 22, 2014  Rescheduling of hydrocodone ... in the pain market, according to a new ... a firm providing market research and consultation exclusively ... Photo - http://photos.prnewswire.com/prnh/20141021/153440 ... for hydrocodone combination products from Schedule III to ...
(Date:10/22/2014)... Investor-Edge has initiated coverage on the following ... Progenics Pharmaceuticals Inc. (NASDAQ: PGNX ), Threshold ... Inc. (NASDAQ: IDRA ), and Merrimack Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,419.48, up 2.40%, the Dow Jones Industrial Average ...
(Date:10/22/2014)...  Charlene Vernak, RPh, of Vernak Farms Pharmacy in ... awarded the George Roentsch Scholarship by the Professional Compounding ... Houston during PCCA,s International Seminar, ... to an independent pharmacist and PCCA member who embodies ... , a well-known pharmacist in the compounding community. ...
Breaking Medicine Technology:Hydrocodone: Rescheduled, Repositioned & Reinvented 2Hydrocodone: Rescheduled, Repositioned & Reinvented 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2
... LA JOLLA, Calif., Sept. 27, 2011 The Wireless-Life ... Wireless Health 2011, where researchers from global institutions such ... universities will share the best new research and significant ... academia, medicine, government and industry. The ...
... Masimo (NASDAQ: ... new study published in the Journal of Critical ... (SpHb®) monitoring has absolute and trending accuracy similar to ... advantages.  Study highlights that "the ability to measure hemoglobin ...
Cached Medicine Technology:Aging-in-Place Research Breakthroughs To Be Presented At Wireless Health 2011 Conference 2Aging-in-Place Research Breakthroughs To Be Presented At Wireless Health 2011 Conference 3Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 2Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 3Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 4Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 5Published Study Demonstrates the Absolute and Trend Accuracy of Masimo Noninvasive and Continuous Total Hemoglobin (SpHb) Monitoring in Intensive Care Unit Patients 6
1.0% Tryptone, 0.5% Yeast Extract, 1.0% Sodium Chloride, 7.5% Glycerol....
Luria bertani broth: 1.0% Tryptone, 0.5% Yeast Extract, 1.0% Sodium Chloride....
Inoculum Broth with Calcium Chloride and Phytone....
12% Tryptone, 24% Yeast Extract, 4.0% Glycerol. Supplied with 1 liter of 10x phosphate buffer (0190-1L)....
Medicine Products: