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Large multicenter study suggests new genetic markers for Crohn's disease
Date:3/26/2008

non-Jewish families was also noted, according to Brant.

What makes these results especially significant is not only the large sample size but also the method we used for screening, namely the use of a high-density, single-nucleotide polymorphism genome-wide linkage process, says Brant. The new process is 10 times faster than older methods at searching the number of variations across the genome, he added.

Up to now, Brant says, no gene regions implicated in IBD were specific to Ashkenazi families, and genetic evidence pointing to why Ashkenazi Jews are twice as likely to get the disorder was lacking. The two genetic regions identified on chromosomes 1 and 3 were specific to Ashkenazi CD and unrelated to known IBD genes.

Although further study is needed to narrow down which specific genes are the major players, Brant says its already clear that they are in the right neighborhood to search for IBD/CD susceptibility genes.


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Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

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