Navigation Links
Large multicenter study suggests new genetic markers for Crohn's disease
Date:3/26/2008

What is believed to be the largest study of its kind for the genetic roots of inflammatory bowel diseases has suggested new links to Crohns Disease as well as further evidence that some people of Jewish descent are more likely to develop it.

The study examined changes in DNA associated with the two most common forms of inflammatory bowel disease (IBD): Crohns Disease (CD), which is most frequently marked by inflammation of the final section of the small bowel (ileum) and parts of the colon, and ulcerative colitis (UC), an inflammation of the internal lining of the rectum and colon.

Results of the study, published in this months edition of Genes and Immunity, included information gleaned from 993 families with IBD, 244 of whom were Ashkenazi Jews. Up to 30 percent of people with IBD in the United States are estimated to have a family history of the condition, and about 25 percent of these families have both CD and UC in the family. People of Ashkenazi Jewish descent are at least twice as likely to develop a form of IBD and are more likely to have familial disease.

This increased risk for some Jewish people makes our study and results especially significant since this is the first sample size of Jewish families, 244, that was large enough to identify novel gene regions for familial predisposition in this ethnic group, says Johns Hopkins gastroenterologist and genetic investigator Steven R. Brant, M.D., senior author of the study.

By analyzing common DNA variations known as single nucleotide polymorphisms, or SNPs, the team found evidence for genes causing familial Crohns Disease in the study population specific to Ashkenazi Jewish families with CD on previously identified areas of chromosomes 1 and 3. They also identified a never-before-identified region of chromosome 13 that was shared by both Jewish and non-Jewish families with CD. Evidence for chromosomal regions that may be linked to UC on chromosome 2 and 19 for Jewish and
'/>"/>

Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. National Association of Subrogation Professionals (NASP), the Largest Insurance Subrogation Association in the World - Announced Today that Leslie Wiernik has Joined the Organization as Director of Education
2. Work time is the largest influence to the duration of a persons sleep
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
5. Texas Largest Physician Carrier Announces 5th Successive Rate Cut on Anniversary of Lawsuit Reform
6. Preventing or reducing enlarged heart decreases risk of heart failure
7. A Place for Mom, Nations Largest Senior Care Referral Service, Fills a Gap in Employee Benefits
8. AHRQ and FDA to Collaborate in Largest Study Ever of Possible Heart Risks with ADHD Medications
9. Worlds Largest Exhibit of Princess Dianas Dresses Hosted by Appleton Museum
10. Largest Privately-Owned Veterinary Practice in the World, Banfield, the Pet Hospital(R), Appoints New Chief Executive Officer
11. Plenary lectures announced for worlds largest osteoporosis congress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Albany, NY (PRWEB) August 01, 2014 ... Surgical Generators Market Outlook to 2020", provides ... Surgical Generators market. The report provides value, ... units) and average prices (in US dollars) ... Electrocautery Generators, Ultrasonic Generators and Argon Plasma ...
(Date:8/1/2014)... August 01, 2014 Oxford Gene ... develops biomarkers. Its products include CytoSure heamatological cancer ... Array, CytoSure ISCA UPD array, CytoSure ISCA sample ... OGT offers services, such as targeted sequencing services, ... miRNA analysis, gene expression analysis, cytosure services and ...
(Date:8/1/2014)... In today’s age, traditional learning methods are futile ... these methods need to be revamped, so that the ... In this age of the internet, online learning resources ... learning management systems help in the planning, implementation, and ... these are proving to be very useful and this ...
(Date:8/1/2014)... Doheny HealthDay Reporter ... pills containing high doses of estrogen, along with some ... in women under 50, new preliminary research suggests. ... researcher Elisabeth Beaber, a staff scientist at the Fred ... formulations increase breast cancer risk while other formulations do ...
(Date:8/1/2014)... Women who serve in the U.S. military are less ... new study suggests. Overall, members of the military ... found that women respond differently to their experience in ... concerns about sexual harassment or being treated unfairly, they ... assault, both within and outside the military, and women ...
Breaking Medicine News(10 mins):Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 2Health News:United Kingdom Surgical Generators Market Size, Share, Analysis, Trends and Forecasts 2020 3Health News:Oxford Gene Technology Market Size, Share, Analysis, Trends and Forecasts 2014 2Health News:Oxford Gene Technology Market Size, Share, Analysis, Trends and Forecasts 2014 3Health News:North America Learning Management System Market is Expected to Reach $5.13 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:North America Learning Management System Market is Expected to Reach $5.13 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:North America Learning Management System Market is Expected to Reach $5.13 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Some Birth Control Pills May Up Breast Cancer Risk 2Health News:Some Birth Control Pills May Up Breast Cancer Risk 3Health News:Women in Military Drink Less Than Civilians, Report Shows 2
... died during the first days of January and many ... tuberculosis//. ,This was disclosed by the ... Indigenous Peoples' Organization (Opittamp), Elton Rodrigues Paes, who has ... the necessary treatment to the peoples in the River ...
... this week we’re looking at efforts to fight malaria. One ... IRS//. Insecticides are applied to the interior walls of homes ... disease. With IRS, protection can be guaranteed for up ... who chairs a U.N. Committee on Science and Technology and ...
... Researchers at UT Southwestern Medical Center have found a new ... to turn on genes could lead to therapeutics// for conditions ... This gene-activating method provides researchers with a novel research tool ... ,In a paper appearing online at Nature ...
... Medical School researchers report that a single protein in brain ... to insulin// and leptin, and energy balance. Their research findings ... cells were reported in the February issue of the Journal ... early to say how this protein could be useful in ...
... Government has come down heavily on alternative therapists who ... are about one lakh therapists said to exist in ... tab on these professionals. On the other hand, completely ... Medical Council have strict rules and guidelines regarding their ...
... announced that it is teaming up with Weight Watchers for ... fight obesity in more than 75000 people in the Mountain ... are eligible to take up this 16-week course from Weight ... points to different foods. This program is free, but participants ...
Cached Medicine News:Health News:Malaria and TB Kills Indian Kids in Brazil 2Health News:IRS Helps Curb Malaria in the Tropics 2Health News:A Novel Technique Nudges Genes Into Activity 2Health News:A Novel Technique Nudges Genes Into Activity 3Health News:A Protein in Brain Cells Controls Obesity: Research 2Health News:A Protein in Brain Cells Controls Obesity: Research 3Health News:A Protein in Brain Cells Controls Obesity: Research 4
(Date:8/1/2014)... Aug. 1, 2014 Research and ... "Global Medical Biosensors Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Medical biosensors are used ... physicochemical detectors. These biosensors monitor health status, disease ... non-invasive methods. They are cost-effective and user-friendly devices. ...
(Date:8/1/2014)... PALO ALTO, Calif. , Aug. 1, 2014 ... today announced a partnership to expand awareness of proper ... the CFChef Shares program. CFChef Shares will run from ... AbbVie,s CFChef program – an online resource for CF ... a healthy diet by submitting recipes to the ...
(Date:8/1/2014)... -- According to the new research ... infective), Basic (Films, Cleansing), Advanced (Hydrogels, Hydrocolloids, Alginate, ... Relief Devices, NPWT) - Global Forecast to 2019" ... expected to reach $18.3 Billion by 2019 from ... of 3.2% from 2014 to 2019. ...
Breaking Medicine Technology:Global Medical Biosensors Market 2014-2018: Key Vendors are Abbott, Bayer, LifeScan and F. Hoffmann-La Roche 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 3Wound Care Market Worth $18.3 Billion by 2019 2Wound Care Market Worth $18.3 Billion by 2019 3
... Stiefel, a GSK company, today announced the launch of the ... the United States. The launch will occur in the technical ... New Orleans. Indicated for the treatment of acne, Stiefel will ...   PanOxyl ® Acne Creamy Wash will be available in ...
... MEDfx Corporation today announced a Direct Project pilot that ... of the standards and protocols supported by the Direct ... in, and is a contributor to, the nationally-sponsored Direct ... Health IT.  The MEDfx Direct pilot will be demonstrated ...
Cached Medicine Technology:Stiefel Launches Most-Prescribed BPO Wash Formulations Over-the-Counter 2MEDfx to Harmonize the Direct Project With CONNECT 2MEDfx to Harmonize the Direct Project With CONNECT 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: