Navigation Links
Large lung cancer study shows potential for more targeted therapies
Date:9/9/2012

A nationwide consortium of scientists has reported the first comprehensive genetic analysis of squamous cell carcinoma of the lung, a common type of lung cancer responsible for about 400,000 deaths each year.

"We found that almost 75 percent of the patients' cancers have mutations that can be targeted with existing drugs -- drugs that are available commercially or for clinical trials," says one of the lead investigators, Ramaswamy Govindan, MD, an oncologist at Washington University School of Medicine in St. Louis and co-chair of the lung cancer group of The Cancer Genome Atlas.

The research appears online Sept. 9 in Nature.

The Cancer Genome Atlas project combines efforts of the nation's leading genetic sequencing centers, including The Genome Institute at Washington University, to describe the genetics of common tumors with the goal of improving prevention, detection and treatment. The Cancer Genome Atlas is supported by the National Cancer Institute and the National Human Genome Research Institute, both parts of the National Institutes of Health (NIH).

The other lung cancer co-chairs are the study's senior author Matthew Meyerson, MD, PhD, of the Broad Institute of Massachusetts Institute of Technology and Harvard University, and Stephen Baylin, MD, of Johns Hopkins University.

The study examined the tumors and normal tissue of 178 patients with lung squamous cell carcinoma. The investigators found recurring mutations common to many patients in 18 genes. And almost all of the tumors showed mutations in a gene called TP53, known for its role in repairing damaged DNA.

Interestingly, the researchers noted that lung squamous cell carcinoma shares many mutations with head and neck squamous cell carcinomas, supporting the emerging body of evidence that cancers may be more appropriately classified by their genetics rather than the primary organ they affect.

"We clearly see mutations in lung cance
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Worlds largest meeting of ear, nose, and throat doctors
2. Fruit flies on methamphetamine die largely as a result of anorexia
3. Men with large waists face an increased risk of frequent urination
4. Obesity in type 2 diabetes: Recommendations from guidelines are largely consistent
5. Human papillomavirus types do not replace others after large-scale vaccination
6. Largest review of management and treatment of Barretts dysplasia and adenocarcinoma
7. HIV suppression not as good as previously thought, largest study of viral-load blood tests show
8. Large Breasts Can Take Mental, Physical Toll on Teens
9. Could a larger waistline be a result of too much TV as a child?
10. Obesity, larger waist size associated with better outcomes in heart failure patients
11. OnPage Provides Secure, Rapid Response at New England’s Largest Catholic Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... created a new technology for modifying human cells ... body and selectively target cancer and other sites ... monitor and modify human physiology is a promising ... technology enabled bioengineers to build such devices that ... a customized fashion. , "The project addressed a ...
(Date:4/17/2014)... estimated that as many as 10 million older Americans ... loneliness and isolation. , However, new research a ... older Americans for six years found that Internet ... depression by more than 30 percent. , "That,s a ... University professor of telecommunication, information studies and media who ...
(Date:4/17/2014)... a new mechanism that allows blood to enter the ... and the Salk Institute have opened the door to ... damage. , A complex and devastating neurological condition, stroke ... for disability in the U.S. The blood-brain barrier is ... into the brain, causing the permanent deficits in movement ...
(Date:4/17/2014)... Calif.) An international team led by researchers at ... complex, which plays a key role in cell division, ... This is the first time the complex has been ... make cyclin B1/Cdk1 an excellent target to control cellular ... The research was published online today in the journal ...
(Date:4/17/2014)... Population Council scientists and their partners have found that ... prevent the transmission of multiple sexually transmitted infections (STIs) ... herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV). ... the gel is effective against multiple strains of HIV, ... against all three viruses of at least eight hours ...
Breaking Medicine News(10 mins):Health News:Building 'smart' cell-based therapies 2Health News:Internet use can help ward off depression among elderly 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2
... National Dementia Screening Policy , , ... the nation faces a public health crisis related to ... the Alzheimer,s Foundation of America (AFA) disputes an ongoing ... The report shatters unsubstantiated criticism and instead emphasizes the ...
... Non-Contact Medical Device Innovations - the Future of Patient ... in Outer Space , , ... Noninvasive Medical Technologies, Inc. (NMT), a medical device company ... for military and civilian medical use, today announced that ...
... /PRNewswire-Asia-FirstCall/ -- China Shenghuo,Pharmaceutical Holdings, Inc. (NYSE Alternext ... that the Company is expanding its herbal-based,"12 Ways" ... markets in Mainland China. , ... its "12 Ways" brand of cosmetics products,to eleven ...
... PatentStorm, the searchable website of millions of U.S. patents, has expanded ... applications. PatentStorm has also completed a host of other improvements, making ... ... Washington, DC (PRWEB) December 9, 2008 -- PatentStorm ...
... China, Dec. 9 /PRNewswire-Asia-FirstCall/ -- China Sky One ... (Nasdaq: CSKI ), a leading,fully integrated ... of China ("PRC"), announced today that its subsidiary,Peng ... production approval from the State Food and Drug ...
... for Low-dose, Weekly Contraceptive Patch to be Presented at ACOG ... , PRINCETON, N.J., Dec. 9 Agile ... products, today announced that two abstracts from Phase 2 studies ... by the American College of Obstetricians and Gynecologists Annual ...
Cached Medicine News:Health News:New Study Disputes Ongoing Controversy Over Memory Screenings 2Health News:New Study Disputes Ongoing Controversy Over Memory Screenings 3Health News:New Study Disputes Ongoing Controversy Over Memory Screenings 4Health News:U.S. Air Force Awards Noninvasive Medical Technologies $2.4 Million Contract 2Health News:U.S. Air Force Awards Noninvasive Medical Technologies $2.4 Million Contract 3Health News:China Shenghuo Announces Additional Roll-Out of '12 Ways' Cosmetics Products to Watsons Stores 2Health News:China Shenghuo Announces Additional Roll-Out of '12 Ways' Cosmetics Products to Watsons Stores 3Health News:China Shenghuo Announces Additional Roll-Out of '12 Ways' Cosmetics Products to Watsons Stores 4Health News:PatentStorm Releases U.S. Patent Applications and Other Features 2Health News:China Sky One Medical, Inc. Obtains Production Rights for Two New Drugs 2Health News:China Sky One Medical, Inc. Obtains Production Rights for Two New Drugs 3Health News:Agile Therapeutics Abstracts on Lead Product, AG200-15 Accepted by ACOG 2Health News:Agile Therapeutics Abstracts on Lead Product, AG200-15 Accepted by ACOG 3Health News:Agile Therapeutics Abstracts on Lead Product, AG200-15 Accepted by ACOG 4
(Date:1/15/2014)... , January 15, 2014 BreedIT Corp ... exclusive worldwide distributor of highly sophisticated agro-breeding solutions for ... 7, 2014, the Company,s board of directors appointed chemistry ... as its new member of the board. ...
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB ... composition of matter, biological targets, mechanism of action, methods ... This patent application describes a novel class ... which interfere with the basic homeostatic cellular processes in ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... Forecast – Worldwide Analysis ... Market Analysis Insulin ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... July 12 Endo Pharmaceuticals (Nasdaq: ENDP ) today ... offer by its wholly owned subsidiary, HT Acquisition Corp., for all ... HTRN).  American Stock Transfer & Trust Company, the depositary for the ... , New York City time, on July 9, ...
... 12 Signum Biosciences announced that its ... Medirepair® with Signum,s compound Arazine™ (n-acetyl-s-farnsylcysteine or AFC) ... compound from Signum,s novel anti-inflammatory platform to be ... (STMs). The DRx AFC Medirepair® website can be ...
Cached Medicine Technology:Endo Pharmaceuticals Announces Expiration of Subsequent Offering Period of Tender Offer for HealthTronics, Inc. 2Endo Pharmaceuticals Announces Expiration of Subsequent Offering Period of Tender Offer for HealthTronics, Inc. 3Endo Pharmaceuticals Announces Expiration of Subsequent Offering Period of Tender Offer for HealthTronics, Inc. 4Signum Biosciences, Inc. Announces Commercial Launch of Arazine™ 2Signum Biosciences, Inc. Announces Commercial Launch of Arazine™ 3
... a simple click of the mouse ... mouse cursor to the desired position ... slide and the magnified image is ... Interface (GUI) enables one-click operation of ...
... new Eclipse TS100 is an ... microscope. This high quality tool ... mechanics and increased stability - ... rigid vibration resistant design that ...
Carbide drill bits, cutters, side cutting. Available in various sizes....
... the enclosed polaroid glasses, these polarized ... devise for near point stereopsis which ... perception, the images appear to pop ... test includes circle patterns for depth ...
Medicine Products: