Navigation Links
Large genomic study identifies endometrial cancer subtypes, treatment opportunities
Date:5/1/2013

NEW YORK, MAY 1, 2013 Endometrial tumors can be reclassified into distinct subtypes based partly on their genomic makeup and may respond to targeted drugs already being tested in clinical trials, according to a large-scale genomic analysis led by researchers at Memorial Sloan-Kettering Cancer Center and other centers within The Cancer Genome Atlas (TCGA) Research Network.

Published in the May 2 issue of the journal Nature, the findings may help doctors more accurately diagnose endometrial cancer and choose treatments that will target genomic mutations in women with endometrioid and uterine serous adenocarcinomas, the two most common types of endometrial cancer. The findings could also guide clinical trials and the development of new drugs.

"These findings have an immediate therapeutic application, as patients with endometrial cancer can be tested routinely to see whether they qualify for a targeted therapy clinical trial," said Memorial Sloan-Kettering gynecologic oncologist Douglas A. Levine, MD, corresponding author on the study, principal investigator of Memorial Sloan-Kettering's TCGA Tissue Source Site, and Co-Chair of TCGA's Endometrial Working Group. "The current landscape of treatment for endometrial cancer is quite chaotic, and this research may provide order to that landscape, especially for more-aggressive endometrial cancers."

Endometrial cancer, which forms in the tissues lining the uterus, is the fourth leading type of cancer among women and the eighth leading cause of cancer death. Endometrioid tumors are usually less aggressive, while uterine serous tumors are more aggressive.

There has been little agreement among doctors over the best treatment approach following surgery for patients with a high risk of recurrence, with decisions relying largely on a tumor's pathology. However, it is difficult for pathologists to reliably differentiate high-grade endometrioid tumors from uterine serous tumors.


'/>"/>
Contact: Caitlin Hool
hoolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. BroadConnect Telecom Now Has the Largest Ethernet over Copper Footprint in the Nation As Result of Completion of National EoC Rollout
2. Princeton Ivy Capital Advisors LLC Receives #1 Rank According to Money Manager Review (MMR is an Independent Third Party Ranking Authority) for Large Cap Core Managers
3. Nation’s Largest Healthy Vending Company Announces Its Continued Growth
4. New Procedure May Shrink Enlarged Prostate Without Surgery
5. Registration opens for Asia-Pacifics largest medical conference on osteoporosis
6. Teen Boys With Enlarged Breasts Show Emotional Effects
7. Ms. Viola Richardson, Jersey City Councilwoman-at-Large, Participates in the Annual Steve Sobel SYC 2013 Fencing Competition
8. Picky Eating in Youngsters Might Be Largely Caused by Genes
9. People With Mental Illness Make Up Large Share of U.S Smokers
10. On March 1, 2013 SBSI Training & Development Solutions Went into Operations Providing Training and Development Solutions to Midsized and Large Organizations
11. Large study finds that physician gender does not affect patient-care costs or mortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... living in disadvantaged neighborhoods have worse musculoskeletal pain ... motor vehicle collision than individuals from higher socioeconomic ... such as age, sex, income, education, and employment ... multi-site research study led by Samuel McLean, MD, ... at the University of North Carolina School of ...
(Date:9/18/2014)... September 18, 2014 It is almost time ... or walk for healthier and happier kids. The South ... in the 4th Annual Miami Children’s Hospital 5K Run/Walk. ... http://www.hyundaihopeonwheels.org , The 5K will take place on ... be outside of Coral Gables City Hall located at 405 ...
(Date:9/18/2014)... Good Neighbor Pharmacy, a national independent ... Pharmacy University, an online central resource for network ... empower pharmacy owners and their staff in today’s ... evolve, Good Neighbor Pharmacy is a partner to ... to help their businesses thrive,” said Scott Robinson, ...
(Date:9/18/2014)... parents eat more vegetables and drink less sugar, according ... Columbia. But it,s still not enough, the study goes ... when it comes to eating healthier at school , ... of socioeconomic status, may inform a child,s diet. , ... some post-secondary education were 85 per cent more likely ...
(Date:9/18/2014)... Relias Learning, the leader in SaaS-based training and ... announced it has been named to the Inc. 5000 list ... , In the three-year period from 2010 to 2013, Relias ... on the Inc. 5000 list to 1,025 from the company’s ... we serve continue to grow, and the need for quality ...
Breaking Medicine News(10 mins):Health News:Living in a disadvantaged neighborhood worsens musculoskeletal pain outcomes after trauma 2Health News:South Florida Hyundai Dealers Association Proudly Support the 4th Annual Miami Children’s Hospital 5K Run/Walk this Saturday August 20th in Coral Gables 2Health News:South Florida Hyundai Dealers Association Proudly Support the 4th Annual Miami Children’s Hospital 5K Run/Walk this Saturday August 20th in Coral Gables 3Health News:Good Neighbor Pharmacy University Keeps Pharmacists Ahead of the Curve 2Health News:Kids eat better if their parents went to college 2Health News:Relias Learning Named to Inc. 5000 List for Second Consecutive Year 2
... (Nov. 3, 2011) Because the incidence of malignant ... the U.S., researchers at Moffitt Cancer Center in Tampa, ... Carolina University and the University of Arizona are working ... malignant melanoma diagnosis and therapy. A tool of great ...
... Reinberg HealthDay Reporter , WEDNESDAY, Nov. 2 ... therapy prolongs survival among men whose cancer has spread ... These men have what is called high-risk, or locally ... to 25 percent fall into this category. In the ...
... 3 (HealthDay News) -- The first artificial heart valve ... approved by the U.S. Food and Drug Administration. ... an aortic heart valve damaged by senile aortic valve ... deposits that cause the valve to narrow. One ...
... Severe early childhood caries can destroy most of a ... populations, including American Indians and Alaskan natives. Although the ... early childhood caries has been known for almost a ... are responsible for the disease has remained elusive. ...
... (HealthDay News) -- Allergy shots are time-tested treatments ... relief to allergy sufferers within weeks instead of months, ... currently given under the skin (subcutaneously), new methods of ... week,s annual scientific meeting of the American College of ...
... , WEDNESDAY, Nov. 2 (HealthDay News) -- A compound currently ... hemophilia patients also seems to be effective in preventing bleeds ... in the Nov. 3 edition of the New England ... last long, the results do raise the possibility that, over ...
Cached Medicine News:Health News:Researchers help in search for new ways to image, therapeutically target melanoma 2Health News:Radiation Plus Hormone Therapy Extends Life in High-Risk Prostate Cancer 2Health News:Radiation Plus Hormone Therapy Extends Life in High-Risk Prostate Cancer 3Health News:FDA OKs Heart Valve That Does Not Require Open-Heart Surgery 2Health News:FDA OKs Heart Valve That Does Not Require Open-Heart Surgery 3Health News:NYUCD awarded $2.2 million NIH grant to decode genome of caries-causing bacteria 2Health News:NYUCD awarded $2.2 million NIH grant to decode genome of caries-causing bacteria 3Health News:Improved Allergy Shots Might Be on Horizon 2Health News:Using Drug for Prevention Might Help in Hard-to-Treat Hemophilia 2Health News:Using Drug for Prevention Might Help in Hard-to-Treat Hemophilia 3
(Date:9/18/2014)... , Sept. 18, 2014  KIYATEC announced today ... Small Business Innovation Research (SBIR) Phase II Contract ... the 27 institutes and centers that comprise the ... of the two year award, KIYATEC will expand ... issues at the forefront of cancer therapy strategies: ...
(Date:9/18/2014)... LONDON , September 18, 2014 ... their audience, has updated the incredibly successful Serialisation Countdown ... The interactive PDF, available at pharmaserialisation.com shows ... in which they will be coming into force. ... no longer a matter of "if", but "when" they ...
(Date:9/18/2014)... ARBOR, Mich. , Sept. 18, 2014  A ... Research will allow the University of Michigan to establish ... The Glenn Center for Aging Research at ... evidence that drugs can slow the effects of aging ... unlock mechanisms of aging that can help develop medications ...
Breaking Medicine Technology:National Cancer Institute Awards KIYATEC Nearly $2M to Advance Predictive Cancer Diagnostics 2National Cancer Institute Awards KIYATEC Nearly $2M to Advance Predictive Cancer Diagnostics 3Pharma IQ Displays Worldwide Serialisation Deadlines in their 2014 - 2018 Countdown Calendar 2$3 M grant funds Paul F. Glenn Center for Aging Research at the University of Michigan 2$3 M grant funds Paul F. Glenn Center for Aging Research at the University of Michigan 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: