Navigation Links
Large UK population study finds no increased cancer risk in children born after assisted conception

London, 9 July 2013: Children born as a result of assisted reproduction (ART) are at no greater risk of cancer than children born spontaneously in the general population, according to results of one of the largest ever cohort studies of ART children. "This is reassuring news for couples considering assisted conception, their subsequent children, fertility specialists and for the wider public health," said the investigators.

Results of the study were presented today at the annual meeting of ESHRE by Dr Carrie Williams from the Institute of Child Health, University College London, UK.

This was a large population-based linkage study between the Human Fertilisation & Embryology Authority (HFEA, the UK's regulatory authority for ART clinics) and the UK's National Registry of Childhood Tumours (NRCT).(1) The HFEA records of all 106,381 children born after assisted conception in the UK from 1992 to 2008 were linked to NRCT records to calculate the number of children who subsequently developed cancer. Once the databases were linked, cancer rates in the ART cohort were compared with population rates, whilst stratifying for potential mediating factors including birth weight, multiple births, treatment type and infertility cause. The average duration of follow up was 6.6 years.

Results showed that there was no overall increased risk of cancer in ART children born throughout the 17-year study period. Overall, 108 cancers were identified in the ART children, which was comparable with the 109.7 cases which would have been expected from general population figures.

However, increased risks were found for the development of certain rare cancer types, though these findings were based on small numbers and the absolute excess risks were small. For instance, significantly more children developed hepatic tumours than expected (6 vs. 1.83), which translated to an added excess risk of 5.94 per million person-years. This excess risk was also associated with a low birth weight.

However, none of the children born after assisted conception who did develop cancer were recorded as having a co-morbidity consistent with an imprinting disorder. This again, said the investigators, is reassuring. The possibility of an increased cancer risk in ART children has been suggested by the discovery of altered epigenetic patterns in embryos.(2)

Commenting on the results, the study's principal investigator, Associate Professor Alastair Sutcliffe from the Institute of Child Health in London, said: "This is the largest study of its kind to be reported and is unique in that the data are derived from a single country and in a homogeneous population. The absence of cancer in children - or in adults - can be considered a measure of long-term health resilience, so we are happy to report that in the country where IVF was first successfully applied there is no convincing evidence that ART children are at any greater risk of cancer than those naturally conceived.

"It is true that we found increased risks of a few rare cancers, but these would need to be studied across large international datasets to confirm if they were genuine findings or just an effect of their very rareness."

Professor Sutcliffe described the overall study results as a "useful bellwether" [guide} for the health of ART children, and future studies will address other unresolved questions over the safety of IVF for mothers and their children.

A similar though smaller study reported at this congress produced comparable findings.(3) The CoNARTaS cohort study from three Nordic countries also found that children and young adults born after IVF had no overall increased risk of cancer when compared with children in the general population. The study group comprised 92,809 children born after IVF between 1982 and 2007 (61,547 singletons and 31,262 multiples), and a matched control group from the general population four times greater in number. Data on perinatal outcomes and cancer were obtained by linkage to national registries.

A cancer diagnosis occurred in 143 children born after IVF (19/1000) and in 626 (18/1000) children in the control group. The most common cancer diagnosis was leukaemia, which occurred in 6/1000 children born after IVF and in 5/1000 in the control group.


Contact: Christine Bauquis
European Society of Human Reproduction and Embryology

Related medicine news :

1. UIC to serve as Chicago site for largest-ever US study of Hispanic/Latino health
2. Market Authority to Release White Paper That Provides Key Strategies for Large Directional Media/Print Companies
3. CyraCom Ranked Amongst the World’s Largest Language Services Providers
4. Smart ERP Solutions Moves Headquarters to New Larger Location
5. North America Leads the Largest Market Share of the Bioinformatics Market Says New Research Report by MarketsandMarkets
6. Challenge of Champions, the Largest Martial Arts Tournament of its Kind in the World, to be Held in Edison, New Jersey
7. Showers Positioned to Replace Bathtubs in Large Hotel Chains – On Trend with Bathroom Remodeling Industry
8. Deadly Super Bug Controlled in Large Study of Hospitals
9. Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet
10. CaringBridge Founder Mehring Reveals Inspiration For World's Largest Support Network In New Book
11. Large Size Condom Sampler Packs Available Now at
Post Your Comments:
(Date:10/13/2015)... ... 2015 , ... In an ongoing effort to provide the ... Texas, child development and pediatric therapy center, is working with TRICARE to emphasize ... options for receiving this kind of care for affected children. Because of concerns ...
(Date:10/13/2015)... ... October 13, 2015 , ... Bambeco, Inc., the premier brand ... announced it closed on a $20.5 million funding round led by ABS Capital ... the Company’s continued rapid growth and expansion, broaden the Company’s product offerings, and ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... team: Debbie Vereb has been named the organization’s Executive Vice President of ... have been hired to key leadership roles in the company. , Debbie Vereb’s ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... show this coming October in Toronto, an exhibition featuring the newest products and ... from, Curly Hair Solutions® couldn’t be more excited to unveil their recent partnership ...
(Date:10/13/2015)... ... October 13, 2015 , ... This ... commercially-available next-generation sequencing laboratory test for bacterial vaginosis- a significant women's health ... Vancouver, BC, Canada. , In a presentation entitled: "The Microbiome and ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Elbit Imaging Ltd. ("EI" or the ... board of directors approved a program to repurchase up to ... H Notes and Series I Notes, which are traded on ... the Company will have a significant preference to the purchase ... to time in the open market on the Tel Aviv ...
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
(Date:10/12/2015)... , October 12, 2015 ... interest from pharmaceutical companies as they look to ... others appear in a new report by  visiongain ... market gains much interest from pharmaceutical companies as ... finding and many others appear in a new ...
Breaking Medicine Technology: