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Large Study of Lacrisert(R) Dry Eye Insert:
Date:5/5/2009

ry Eye Syndrome and Patient Quality of Life" (Bruce H. Koffler for the LAC-07-01 Study Group, poster 4660/D904, Wednesday, May 6, 1:45-3:30 PM).

As reported by Dr. Koffler, mean ocular surface disease index (OSDI) total scores for patients in the study significantly improved by more than 25% over the four weeks of the study; this was over and above any improvement patients may have gained from previous dry eye therapies administered before the study.

Treatment with Lacrisert also resulted in significant improvement in mean occurrence of discomfort in heated areas (P < 0.0001) and significant improvements when performing housework (P = 0.0018). Patients reported significant reductions in mean severity of DES symptoms (P < 0.0001). The most commonly reported adverse event leading to discontinuation was blurred vision, observed in 8.7% of patients.

"The study shows use of Lacrisert results in significant improvements in DES symptoms, in activities of daily living, and in patient quality of life," explained Dr. Koffler.

A second poster at the 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) based on the patient registry study, "Effect of Lacrisert(R) on the Signs and Symptoms of Dry Eye in Contact Lens Wearers" (Wednesday, May 06, 2009, 1:45 PM - 3:30 PM, Hall B/C) will be presented by Stephen J. Curwen et al of Ophthalmic Research Associates (ORA). This poster focuses on a sample subset of 30 contact lens wearers with a history of dry eye.

The 30 contact lens patients reported significant improvements in dryness (P = < 0.0001) and grittiness (P = 0.008) after 4 weeks of dosing with Lacrisert when compared to baseline. Mean TFBUT increased from 2.98 to 4.08 sec. (P < 0.0001) and mean corneal/conjunctival staining decreased from 1.21 to 0.79 units (P < 0.0
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SOURCE Aton Pharma, Inc.
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