Navigation Links
Large Study of Anemia Treatment in Chronic Kidney Disease Patients Not on Dialysis Published in the New England Journal of Medicine Failed to Meet Primary Efficacy Endpoints
Date:10/30/2009

THOUSAND OAKS, Calif., Oct. 30 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN) today announced the publication of results from TREAT (the Trial to Reduce Cardiovascular Events with Aranesp® Therapy), a large, randomized, double-blind, placebo-controlled, Phase 3 pivotal study of patients with chronic kidney disease (CKD) not on dialysis, moderate anemia and type-2 diabetes. The study, published online today in the New England Journal of Medicine and presented at the annual meeting of the American Society of Nephrology (ASN), failed to meet its primary objectives of demonstrating a reduction in all-cause mortality, cardiovascular morbidity, including heart failure, heart attack, stroke, or hospitalization for myocardial ischemia, or end-stage renal disease (ESRD).

The primary endpoints of the study were a composite of time to all-cause mortality or cardiovascular morbidity (including heart failure, heart attack, stroke, or hospitalization for myocardial ischemia) and a composite of time to all-cause mortality or ESRD. Among the components of the primary cardiovascular composite endpoint, the risk of stroke increased by almost two-fold in patients in the Aranesp arm (101 patients [5.0 percent] vs. 53 patients [2.6 percent]; hazard ratio, 1.92; 95 percent confidence interval, 1.38 to 2.68; P<0.001). Although stroke is a recognized risk with erythropoiesis-stimulating agent (ESA) therapy, and has been identified in warnings in United States (U.S.) labeling since 2001, the risk observed in TREAT is of higher magnitude than that seen in previous clinical trials in CKD patients not on dialysis.

A post hoc analysis indicates that there were no significant differences between treatment arms in the incidence of cancer or of all-cause deaths in patients who developed cancer during the trial. However, this analysis also s
'/>"/>

SOURCE Amgen
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Meharry Medical College Receives $21.4 Million NIH Research Grant, Largest in Its History
2. World's Largest Resource for and about Chiropractors, 123Chiropractors.com, Donates $15,000 to Life Chiropractic College West
3. AHDI 2009 President, Susan Lucci, Joins 4th Largest Medical Transcription Company, Webmedx
4. The largest congress worldwide on ion therapy in Heidelberg
5. Largest British Fund for Biomedical Research Finances Project on Breakbone Fever in Leuven (K.U.Leuven)
6. Sams Day Celebrates 5 Year Anniversary; Local Family Event Will Benefit Largest U.S. Non-Profit Fighting Duchenne Muscular Dystrophy
7. Big Top Cupcake(TM) Brand Awarded With Guinness World Record For Worlds Largest Cupcake
8. National Health Care Reformers Should Pay Attention to Lawsuit Alleging that Nations Largest Insurer Routinely Denies Liver Transplants
9. QHR Ranked 7th Largest Healthcare Management Consulting Firm in United States
10. PetDocsOnCall.com Connects Pet Owners to the Largest Online Network of Practicing Veterinarians
11. Largest Survey of Its Kind Finds the Psychological and Social Effects of Psoriasis Greater for Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Energy Textiles has recently added a ... is now available online, and Energy Textile is providing ... infrared-active athletic gear over compression gear. , The ... been signed for Under Armour to provide team gear ... years. In light of this decision, Energy Textiles contemplates ...
(Date:10/31/2014)... (HealthDay News) -- Sleep apnea may make it hard for ... your car or left your house keys, a small study ... showed that this ability -- called spatial memory -- was ... even when other stages of sleep weren,t affected. REM sleep ... occur. "We,ve shown for the first time that sleep ...
(Date:10/31/2014)... duration of treatment and cost, patients with early ... breast irradiation (APBI) with proton therapy versus whole ... The University of Texas MD Anderson Proton Therapy ... study based on typical patient characteristics, researchers used ... eight different types of partial and whole breast ...
(Date:10/31/2014)... out of four older Americans say that either they ... medical treatment, according to the latest issue of The ... Report ( PP&AR ), which goes on to ... they fail to honor patients, end-of-life health care wishes. ... Care: Issues and Options ," features 12 articles that ...
(Date:10/31/2014)... Gold Medal Wine Club is making ... gifts for the wine novice and enthusiasts on their lists ... Special , which Early Bird shoppers receive discounts as high ... membership. , Gift Givers must place their orders before ... discounts, Gold Medal Wine Club adds more value to its ...
Breaking Medicine News(10 mins):Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Advance directives can benefit patients, families, and health care system 2Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2
... treatment, radiation may be a better choice than ... cancer, //according to a randomized controlled trial published ... The authors suggest that a combination of chemotherapy ... for these patients. ,Approximately 80 percent of ...
... finds that survivors of acute lymphoblastic leukemia have a ... the general population. // ,Acute lymphoblastic leukemia is ... almost 4,000 new cases diagnosed in the United States ... curable pediatric cancers: survival rates for patients who receive ...
... a weekly treatment with a nasal spray of virus enzymes ... based on results of a study. Such a treatment would ... avoiding the problem of antibiotic resistance. ,Middle ear ... the middle ear space that can cause pain, fever, irritability, ...
... the state government on a public suit demanding// protection ... litigation (PIL), filed by an NGO, Health, Environment and ... to be protected from silicosis, which is rife due ... malpractice of the mine owners. ,"We had ...
... Pitt donated $100,000 of their money to help// construct the ... ,They made the donation to the Duk Lost Boys Clinic ... in the spring and serve more than 150,000 people. ... of the "lost boys" of Sudan who is the director ...
... urged governments to join the anti-tuberculosis global plan, which ... the disease has become extremely drug-resistant. ,Ban's ... Day on Saturday. The World Health Organization (WHO) recently ... strain of tuberculosis, XDR-TB, which threatens to derail efforts ...
Cached Medicine News:Health News:Radiation Preferred Over Surgery for Patients With Some Stages of Lung Cancer 2Health News:Lymphoblastic Leukemia Survivors at Risk for Secondary Cancer 2Health News:Viral Enzyme Recruited in Fight Against Ear Infection 2Health News:Viral Enzyme Recruited in Fight Against Ear Infection 3Health News:Public Interest Litigation Filed Favoring Mineworkers Against Silicosis 2
(Date:10/31/2014)... Calif. , Oct. 31, 2014 ThynkWare ... sclerosis (ALS) patients initiate text and email messages using ... a patent-pending technology invented by ThynkWare,s founder, Duane ... on a smartphone device. This technology allows users to ... only the power of thought. ThynkWare provides ...
(Date:10/31/2014)... Migranade, Inc. announced today the new migraine ... 36 million U.S. migraine sufferers November, 2014. The medicine ... actual cause of migraines and not just the symptoms. ... source Migranade is assured to be a game changer ... available at http://www.migranade.com and will soon hit ...
(Date:10/31/2014)... NORTH CHICAGO, Ill., Oct. 31, 2014  AbbVie ... results for the third quarter ended Sept. 30, ... the strong performance of our business with double-digit ... Our underlying business grew nearly 14 percent in ... chairman and chief executive officer, AbbVie.  "We exceeded ...
Breaking Medicine Technology:ThynkWare Speech Helps Those with ALS and Locked-In Syndrome Translate Thought to Speech on Their Smartphone Devices 2Game Changing Migraine Medication To Be Available November 2014 2AbbVie Reports Third-Quarter 2014 Financial Results 2AbbVie Reports Third-Quarter 2014 Financial Results 3AbbVie Reports Third-Quarter 2014 Financial Results 4AbbVie Reports Third-Quarter 2014 Financial Results 5AbbVie Reports Third-Quarter 2014 Financial Results 6AbbVie Reports Third-Quarter 2014 Financial Results 7AbbVie Reports Third-Quarter 2014 Financial Results 8AbbVie Reports Third-Quarter 2014 Financial Results 9AbbVie Reports Third-Quarter 2014 Financial Results 10AbbVie Reports Third-Quarter 2014 Financial Results 11AbbVie Reports Third-Quarter 2014 Financial Results 12AbbVie Reports Third-Quarter 2014 Financial Results 13AbbVie Reports Third-Quarter 2014 Financial Results 14AbbVie Reports Third-Quarter 2014 Financial Results 15AbbVie Reports Third-Quarter 2014 Financial Results 16AbbVie Reports Third-Quarter 2014 Financial Results 17AbbVie Reports Third-Quarter 2014 Financial Results 18AbbVie Reports Third-Quarter 2014 Financial Results 19AbbVie Reports Third-Quarter 2014 Financial Results 20AbbVie Reports Third-Quarter 2014 Financial Results 21AbbVie Reports Third-Quarter 2014 Financial Results 22AbbVie Reports Third-Quarter 2014 Financial Results 23AbbVie Reports Third-Quarter 2014 Financial Results 24
... Texas, Oct. 4, 2011 Today, Children,s ... in the state and the only stand-alone facility between Dallas ... Earlier, hospital personnel used Scott & White,s state-of-the-art Simulation Center ... Hospital, which was housed in Scott & White Hospital-Temple, before ...
... OTCQX: RHHBY) announced plans today to expand its coagulation testing ... clinics with the development of a full line of coagulation ... expected to be introduced in the U.S. and Canada in ... Roche Diagnostics is the global market leader in coagulation ...
Cached Medicine Technology:Children's Hospital at Scott & White Opens 2Children's Hospital at Scott & White Opens 3Children's Hospital at Scott & White Opens 4Roche to Expand Coagulation Testing Portfolio, Develop New Systems for Diagnostic Laboratories in US and Canada by 2014 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: