Navigation Links
Lancet Oncology: Long-term side-effects of targeted therapies in pediatric cancer patients
Date:2/7/2013

or 60 years later.

"The message I really want to convey is that our way of treating pediatric cancer has changed entirely in some diseases, and in some it's meant huge progress. A number of us have patients who have literally been cured by these new drugs. There are a lot of really cool therapies out there, but the issue is using them safely. With increased survival, we need to cure kids for 60-70 years. The question is how do we best treat these kids, knowing that cancer remains the enemy but you also don't want to induce complications that negatively affect the rest of their lives," Gore says.

"Personally, one of the most important things when choosing how to treat pediatric patients is to know what I don't know to acknowledge gaps in knowledge. Then as a researcher, we try to fill these gaps so that we can prescribe knowing the balance of risk and reward for these treatments," Porter says.

For now and until these questions are answered, the researchers recommend using molecularly targeted therapies with pediatric patients only in the context of a clinical trial. To Gore, Porter and co-author James DeGregori, PhD, the framework of a clinical trial provides the oversight needed for the rational prescription of these drugs in pediatric patients along with follow-up that includes more definite monitoring of side-effects than what Gore describes as "random use."

"One of the reasons we wrote this paper is that we don't understand the major risks, or even what the major risks might be," Porter says. "These targeted agents may affect the process of development in ways we can't predict."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Indias patent laws under pressure: The Lancet special report
2. Premier global health journal, The Lancet, releases series on universal health coverage
3. LTC Guild Member Releases Guidelines for Securing Long-Term Care Insurance for Parents
4. Prostate cancer study tracks long-term urinary, sexual and bowel function side effects
5. Long-term consequences of vaginal delivery on the pelvic floor
6. Study Links Long-Term Aspirin Use With Vision Loss
7. Gastric banding an effective long-term solution to obesity
8. USF and VA researchers find long-term consequences for those suffering traumatic brain injury
9. The Spencer Institute Supports New Year’s Resolutions and Long-Term Health with Wellness Coach Certification
10. Long-Term Aspirin Use Linked With Vision Loss: Study
11. Long-terms benefits follow brain surgery for certain forms of epilepsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... 2014 Crosley Law Firm is proud to ... have been named to the list of Super Lawyers in ... of personal injury law. , Before receiving the designation ... selection process. First, they must come highly recommended by a ... noteworthy achievement during the past year by obtaining certain honors, ...
(Date:9/15/2014)... Imaging can be a cost-effective way ... benefit from aggressive intervention, according to a new modeling ... The study looked at people with asymptomatic carotid artery ... blood to the head due to atherosclerosis, or plaque ... up to 20 percent of ischemic strokes, which result ...
(Date:9/15/2014)... Authors Christine Snow and Donna Albury highlight ... four alcoholics. Born out of love and pain and the ... In The Life... ” (published by Xlibris) reveals the struggles ... from the same fate. , Night life is popular ... in this. This book chronicles a typical night in the ...
(Date:9/15/2014)... researchers at the University of Copenhagen have gained ... Parkinson,s disease. The findings have recently been published ... , The defining symptoms of Parkinson,s disease ... is currently no cure for the condition, so ... the potential to shed some light on this ...
(Date:9/15/2014)... 2014 DISCcert, a San Diego based ... DISC Certification Workshop for Oct 16th and 17th. ... to take part in the intensive and highly regarded ... activities that can be immediately implemented into their business ... to educate employees and staff in DISC skills. Learning ...
Breaking Medicine News(10 mins):Health News:Thomas A. Crosley and R. Andrew Rodriguez Named 2014 Super Lawyers 2Health News:RSNA: Imaging Identifies Asymptomatic People at Risk for Stroke 2Health News:RSNA: Imaging Identifies Asymptomatic People at Risk for Stroke 3Health News:Authors show perils of alcohol abuse in new graphic novel 2Health News:Authors show perils of alcohol abuse in new graphic novel 3Health News:Researchers debunk myth about Parkinson's disease 2Health News:DISCcert Announces Two-day DISC Certification Workshop Oct 16 and 17 2Health News:DISCcert Announces Two-day DISC Certification Workshop Oct 16 and 17 3
... are more likely to have their work cited than ... a new study released this week by Rice University,s ... scientists are also more likely to receive greater recognition ... "International Stem Cell Collaboration: How Disparate Policies Between the ...
... Institute of Technology have found support for the theory that ... it stores readily available items. Memory researchers have long debated ... capacity and function of each layer is. In a ... Cognitive Psychology, researchers found that short-term memory is made ...
... new study of a common etiquetteholding a door for someonesuggests ... motivation: to reduce the work for those involved. The research, ... State University, is the first to combine two fields of ... to be published in a forthcoming issue of Psychological ...
... The Nobel prize-winning physicist Richard Feynman once wrote in his ... "When I see equations, I see letters in colors - ... hell it must look like to the students." This neurological ... of "seeing" the letters in colour was a specific form ...
... significantly impacts quality of life for patients after ... Hospital. "Transplant recipients with alcoholic cirrhosis experienced ... reported greater pain and physical limitations than non-alcoholics ... Ford Behavioral Health Services, lead author of the ...
... MESA, Ariz. March 8, 2011 Predictive Biomarker ... produced by Unibioscreen, kills cancer cells. Previous studies ... MCL1 can cause cancer cells to grow out of ... non-profit, Phoenix-based Translational Genomics Research Institute (TGen), co-discovered that ...
Cached Medicine News:Health News:Report: International collaboration between researchers results in greater recognition 2Health News:New study proves the brain has 3 layers of working memory 2Health News:More reasons to be nice: It's less work for everyone 2Health News:Reading in 2 colours at the same time 2Health News:Alcohol abuse history influences quality of life following liver transplant 2Health News:PBS-Bio uncovers how Unibioscreen drug kills cancer 2
(Date:9/15/2014)... , Sept. 16, 2014  Bayer HealthCare and ... Finland , have begun to ... ODM-201, an investigational oral androgen receptor inhibitor in ... in men with castration-resistant prostate cancer who have ... detectable metastases. The trial is designed to determine ...
(Date:9/15/2014)... Sept. 15, 2014 /PRNewswire/ -  Pivotal Therapeutics Inc. ... pharmaceutical company with a focus on Omega-3 therapies ... that the Board of Directors approved the granting ... advisor at the close of business on Friday, September ... 1,000,000 common shares of the Company were granted ...
(Date:9/15/2014)... Sept. 15, 2014 /PRNewswire-iReach/ -- On September 8, ... South Carolina, submitted a Citizen Petition to Dr. ... FDA to add another Black Box Warning to ... request asks for a Black Box Warning for ... paranoia, suicidal thoughts or acts, loss of consciousness, ...
Breaking Medicine Technology:Bayer and Orion Initiate Phase III Trial of ODM-201 in Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer 2Bayer and Orion Initiate Phase III Trial of ODM-201 in Men with High-Risk Non-Metastatic Castration-Resistant Prostate Cancer 3Pivotal Therapeutics Grants Incentive Stock Options 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 3
... , , FARMINGDALE, N.Y., Jan. 8 Misonix, Inc. ... medical device technology, which in Europe is used for the ... has entered into a new, three year distribution agreement with ... Saudi Arabia, for the distribution of the SonaStar(TM) Ultrasonic Surgical ...
... N.Y., Jan. 8 VirtualScopics, Inc. (Nasdaq: VSCP ... trials, announced today that Ms. Molly Henderson, the company,s ... corporate overview at the upcoming OneMedPlace Finance Forum at ... annually, the OneMedPlace Finance Forum was created to connect ...
Cached Medicine Technology:Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 2Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 3VirtualScopics to Present at the Upcoming OneMedPlace Investment Conference 2VirtualScopics to Present at the Upcoming OneMedPlace Investment Conference 3
... The FoamWrap ACTION Elbow Wrap replaces messy ... players, golfers, and others experiencing epicondylitis. Preferred ... application and non-bulky fit. Two overlay straps ... Breathable, non-slip foam lining holds the Elbow ...
... Brace is designed to handle post-op elbow ... The Bledsoe Extender Arm Brace should be ... of the elbow is desired. In most ... be formed, fitted and adjusted in 5 ...
... lightweight brace allows it to fit easily into ... joint following severe sprains, tendonitis or after cast ... with the ankle and provide optimum medial-lateral support. ... rotational strains on the ankle, and they provide ...
... stretch ankle support helps reduce swelling and minimize ... It is easy to apply - it slips ... fits easily into shoes. It features bilateral ... provide side-to-side support and stability. This is ...
Medicine Products: