Navigation Links
Lancet Oncology: Long-term side-effects of targeted therapies in pediatric cancer patients
Date:2/7/2013

A University of Colorado Cancer Center review published this week in the journal Lancet Oncology describes possible long-term side-effects of new, targeted therapies in pediatric cancer patients: what we don't know may hurt us.

"As pediatricians who treat kids with cancer, we expect the side-effects of traditional chemotherapies: low white blood count, infections, even long-term heart trouble or infertility. But there's the impression that these new, molecularly targeted agents are much less toxic. That may be true, especially in adult patients, but until we have more information about the long-term effects of these therapies in children, we need to be careful about how and when we prescribe them," says Chris Porter, MD, CU Cancer Center investigator and assistant professor of Pediatrics at the University of Colorado School of Medicine.

Already we know that molecularly targeted therapies may stunt the growth of pediatric patients, delay puberty or speed the onset of diabetes. And researchers are just now starting to ask about additional, sometimes unforeseen side-effects, potentially including more subtle issues such as neurocognitive, balance and motor defects.

"The growth of cancer cells isn't that different than the growth of a 7-pound baby into a 210-pound teenage linebacker. Now, you shut down these growth pathways in an adult and it might not be a big deal, but you shut down these same pathways at a critical time in childhood development and you can have real problems," says Lia Gore, MD, CU Cancer Center investigator and associate professor of Pediatrics and Medical Oncology at the CU School of Medicine.

The practical problem is this: FDA approval of many of these drugs for adult use allows physicians to prescribe the same drugs for pediatric use. Many are pills orally administered, outpatient treatments that make it difficult to recognize and track possible side-effects even in the short-term, let alone 10, 15
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Indias patent laws under pressure: The Lancet special report
2. Premier global health journal, The Lancet, releases series on universal health coverage
3. LTC Guild Member Releases Guidelines for Securing Long-Term Care Insurance for Parents
4. Prostate cancer study tracks long-term urinary, sexual and bowel function side effects
5. Long-term consequences of vaginal delivery on the pelvic floor
6. Study Links Long-Term Aspirin Use With Vision Loss
7. Gastric banding an effective long-term solution to obesity
8. USF and VA researchers find long-term consequences for those suffering traumatic brain injury
9. The Spencer Institute Supports New Year’s Resolutions and Long-Term Health with Wellness Coach Certification
10. Long-Term Aspirin Use Linked With Vision Loss: Study
11. Long-terms benefits follow brain surgery for certain forms of epilepsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... 2013 Many orthodontists have thought about ... exactly that cloud is. Most people would naturally ... to provide their cloud service and support would own ... service they're selling, they'd be wrong. Cloud providers ... secure, redundant facility that houses servers and related equipment ...
(Date:5/25/2013)... (PRWEB) May 25, 2013 According to ... most beautiful and powerful women that ever lived. Cleopatra’s ... by some of the most powerful men in her ... beauty remedies to keep her skin glowing and fresh, ... with bees- wax, maringa oil and cyprus grass. , ...
(Date:5/25/2013)... The Slim Weight Patch has been clinically ... is due to the highly sought after ingredients that have ... offers an extra 2 months supply & premium membership of ... the body you desire faster than ever. , Click ... With Slim weight patch consumers can observe instant results within ...
(Date:5/25/2013)... Prairie Living at Chautauqua , ... American Red Cross Blood Drive from 1:30 to 5:30 ... is located at 955 Villa Ct. in Carbondale, Illinois, ... Medicaid, who need some help to maintain their independence.. ... Andrea Arview Frey, Director of Marketing for Prairie Living. ...
(Date:5/25/2013)... May 25, 2013 Ayurveda is ... or wisdom of life". While a medical science, its scope ... of consciousness. Its fundamental philosophy is that disease is the ... In order to re-establish optimal health, one must discover where ... life style which brings us back into perfect harmony. , ...
Breaking Medicine News(10 mins):Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 2Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 3Health News:Slim Weight Patch Advanced Weight Loss System Offers Extra Two Month Supply and Membership for Maximum Weight Loss 2Health News:Carbondale Affordable Assisted Living Community to Host Red Cross Blood Drive 2Health News:Fundamentos de Ayurveda in Mexico (Ayurvedic Principles) Offered by Escuela de Ayurveda de California 2
... threshold of a new era based on better understanding ... each other. There is great potential for exploiting the ... to develop new drugs that act more specifically without ... nature. , A recent workshop on Biosupramolecular Chemistry ...
... The National Lung Cancer Partnership announced today ... Foundation, the Oncology Nursing Society Foundation and the International ... the mission to increase opportunities for lung cancer researchers ... Lung cancer is the leading cancer killer of men ...
... Study found adults ate worse than children did in ... Members of poor households in which it is consistently ... nutritionally risky diets, Canadian researchers reveal. , The new ... directly translates into poor nutrition. It also suggests that ...
... A new take on pilots, health,workplace injuries connected ... studies to be presented at Preventive Medicine 2008,the ... 2008 in Austin, Texas., Long-Haul Flights May ... investigated if acute stress phenomena associated with,frequent take ...
... Lady Laura Bush,today visited the Maamobi Polyclinic in ... two interventions being implemented by AED to control,malaria., ... with Ghana,s commercial,sector to increase the availability and ... in Ghana and five,other sub-Saharan African countries, and ...
... working together to provide dental offices with exposure, to ... Optimizer(R) and other Sikka Software products that assist, dentists and ... financial performance of their practice. Dental Economics will utilize,Sikka Software,s ... ...
Cached Medicine News:Health News:New understanding of how big molecules bind will lead to better drugs, synthetic organic materials 2Health News:New understanding of how big molecules bind will lead to better drugs, synthetic organic materials 3Health News:National Lung Cancer partnership 2Health News:Poverty Drains Nutrition From Family Diet 2Health News:Poverty Drains Nutrition From Family Diet 3Health News:News Briefs from Preventive Medicine 2008 2Health News:News Briefs from Preventive Medicine 2008 3Health News:First Lady Laura Bush Visits AED/Netmark Malaria-Control Project in Ghana 2Health News:Sikka Software and Dental Economics Announce Alliance 2
(Date:5/24/2013)... 24, 2013 The potential of ... delivery of therapeutic agents has been receiving undeniable attention ... showing significant promise. The crucial formulation considerations for orally ... play a major role in the efficiency of pulmonary ... development of new formulation techniques and devices in recent ...
(Date:5/23/2013)... DIEGO , May 23, 2013 Neurocrine Biosciences, ... Kevin Gorman , President and Chief Executive Officer ... 38 th Annual dbAccess Health Care Conference in Boston.   ... May 30 at 11:20 a.m. Eastern Time / 8:20 a.m. ... accessed on the Company,s website at http://www.neurocrine.com . ...
(Date:5/23/2013)... , May 23, 2013  MGC Diagnostics Corporation ... global medical technology company, today scheduled a conference call ... of fiscal year 2013, ended April 30, 2013. The ... May 30, 2013. The Company will report financial results ... the markets close on Thursday, May 30, 2013. ...
Breaking Medicine Technology:Inhalaltion Drug Delivery: 11-12 September - Berlin, Germany 2MGC Diagnostics Corporation to Report Second Quarter Fiscal 2013 Financial Results on Thursday, May 30, 2013 2
... 22, 2011 Regeneron Pharmaceuticals, Inc. (NASDAQ: ... Food and Drug Administration (FDA) has accepted for review ... Injection for Subcutaneous Use for the prevention of gout ... Prescription Drug User Fee Act (PDUFA), the goal for ...
... Endoscopy, Inc.,s (OTCPK: SNDY) is pleased to announce that ... of $73,895.  Solos Endoscopy has consummated agreements which resulted ... Three Months period ending September 30, 2011.  The signed ... reduction of ongoing expenses by approximately $40,000 per quarter. ...
Cached Medicine Technology:Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 2Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 3Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 4Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 5Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 6Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 7Regeneron Announces FDA Acceptance of ARCALYST® (rilonacept) Supplemental Biologics License Application for Review 8Solos Endoscopy Finishes the 3rd Quarter With a Net Profit 2
Pipetman P is a fully adjustable, air-displacement pipette with the selected volume shown on a digital indicator (volumeter). Eight models cover the full range of volumes from 0.2 L to 10 mL....
... moderate viscosity and density. Proven ergonomic design reduces hand fatigue, prevents injury. ... (ul) ... 2~5 Imprecision(%) ... 0.01 Dimensions: ...
... the range from 2ul to 5000ul. Fills ... design prevents inadvertent volume change. Novel hand ... pipette is autoclavable at 121C(250F). To prevent ... Suitable for one-handed operation. Auto or Normal ...
... fully adjustable, air-displacement pipette with a patented ... member of the Pipetman family, sharing many ... precision. We also added a number of ... Eight models cover the full range of ...
Medicine Products: