Navigation Links
Lactic acid found to fuel tumors
Date:11/20/2008

DURHAM, N.C., and BRUSSELS, BELGIUM A team of researchers at Duke University Medical Center and the Universit catholique de Louvain (UCL) has found that lactic acid is an important energy source for tumor cells. In further experiments, they discovered a new way to destroy the most hard-to-kill, dangerous tumor cells by preventing them from delivering lactic acid.

"We have known for more than 50 years that low-oxygen, or hypoxic, cells cause resistance to radiation therapy," said senior co-author Mark Dewhirst, DVM, Ph.D., professor of radiation oncology and pathology at Duke. "Over the past 10 years, scientists have found that hypoxic cells are also more aggressive and hard to treat with chemotherapy. The work we have done presents an entirely new way for us to go after them."

Many tumors have cells that burn fuel for activities in different ways. Tumor cells near blood vessels have adequate oxygen sources and can either burn glucose like normal cells, or lactic acid (lactate). Tumor cells further from vessels are hypoxic and inefficiently burn a lot of glucose to keep going. In turn, they produce lactate as a waste product.

Tumor cells with good oxygen supply actually prefer to burn lactate, which frees up glucose to be used by the less-oxygenated cells. But when the researchers cut off the cells' ability to use lactate, the hypoxic cells didn't get as much glucose.

For the dangerous hypoxic cells, "it is glucose or death," said Pierre Sonveaux, professor in the UCL Unit of Pharmacology & Therapeutics and lead author of the study, published in the Nov. 20 online edition of the Journal of Clinical Investigation. He formerly worked with Dr. Dewhirst at Duke.

The next challenge was to discover how lactate moved into tumor cells. Because lactate recycling exists in exercising muscle to prevent cramps, the researchers imagined that the same molecular machinery could be used by tumor cells.

"We disc
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-323-0179
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
2. One Species Genome Found Within Another
3. National Patient Safety Foundation Partners with Vocera Communications
4. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
5. Patient Advocate Foundation Launches Program to Help Uninsured Virginians with Chronic, Debilitating and Life-Threatening Illness Access Quality Healthcare
6. AIDS Healthcare Foundation Applauds City Commissioners Support of Diversity, Urges Call for Mayors Resignation
7. National Osteoporosis Foundation Teams Up With Ladies Home Journal Magazine to Launch a 10-city Mall Walk Tour
8. Judge Rules That Florida Disease Management Program Serving 8,000 HIV/AIDS Patients Should Be Re-bid, Says AIDS Healthcare Foundation
9. The Tug McGraw Foundation Announces 2007 Fundraising Gala
10. The Arthur M. Blank Family Foundation Pushes for Pre-K Expansion in Georgia
11. Cipla, Tell the Truth; AIDS Healthcare Foundation Launches New Ad Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... (PRWEB) December 26, 2014 “Every three months ... market changes. A-line sweetheart evening dress will be one of ... sales manager of Yunx.co.uk says. Today, the company releases 26 ... discounts, up to 80% off. , “We are trying ... unique style with our latest designs. Along with affordable prices, ...
(Date:12/25/2014)... December 25, 2014 The short film “Color ... created in honor of a true 9/11 hero, Welles Remy ... festivals including the 24 hours of Nuremberg International Short Film ... , Actress, screenwriter and director Luciana Lagana ... film together with her husband, Gregory Graham - ...
(Date:12/25/2014)... Woodland Hills, California (PRWEB) December 25, 2014 ... in her home in Woodland Hills, California after an ... Harris passed away on Christmas Eve evening in her ... battle with aggressive metastatic breast cancer. ... International for over forty years, she pioneered and championed ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, ... illnesses can receive effective, less expensive care from a clinic ... a team of dedicated health care professionals, a new study ... and need either hospitalization or a trip to the emergency ... clinic at the University of Texas in Houston versus usual ...
(Date:12/25/2014)... 2014 (HealthDay News) -- Among early stage breast cancer ... half of one percent will eventually develop leukemia as ... The finding comes from a review of more ... 2007, and it suggests that the risk for developing ... had previously thought. "The frequency of bone marrow ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... , SOUTH SAN FRANCISCO, Calif., July 10 ... the International Society on Thrombosis and Haemostasis (ISTH) XII ... drug elinogrel, a P2Y(12) ADP receptor antagonist currently in ... inhibitor anticoagulant antidote in pre-clinical development, as well as ...
... adulthood, study shows , THURSDAY, July 9 (HealthDay News) ... can persist into adulthood, U.S. researchers report. , Young ... than 5.5 pounds at birth) have an increased risk ... findings suggest that not only are [low birth weight] ...
... ... are now available in Canada from Electro Sonic. , ... Chatsworth, CA (PRWEB) July 10, 2009 -- NMB Technologies Corporation, a ... have reached a distribution agreement. Under the terms of this agreement, Electro Sonic, ...
... 10 Eli Lilly and Company (NYSE: ... 35th year of support for the Indiana Black Expo (IBE) Summer Celebration, ... presence at the IN Shape Indiana Black and Minority ... in these uncertain economic times. , , An example of this ...
... Growing in the number of those afflicted, Alzheimer,s takes ... caregivers, "Alzheimer,s Days Gone By: For Those Caring For Their ... Lueckenotte weaves a heartfelt mix of personal experience and sound ... of loved ones during the descent into dementia. , ...
... (Nasdaq: QGLY ) , ... Rosenbloom has resumed providing services to the Company,s Quigley Pharma subsidiary. ... late May, 2009. , , Ted Karkus, Chairman and interim ... Rosenbloom again serving our Pharma subsidiary and helping in the development ...
Cached Medicine News:Health News:Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress 2Health News:Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress 3Health News:Respiratory Issues Linger for Smallest Babies 2Health News:NMB Expands in Canada 2Health News:Lilly Celebrates Its 35th Year as a Supporter of the Indiana Black Expo 2Health News:Lilly Celebrates Its 35th Year as a Supporter of the Indiana Black Expo 3Health News:Insightful Handbook for Alzheimer's Caregivers 2Health News:Insightful Handbook for Alzheimer's Caregivers 3Health News:Dr. Richard Rosenbloom Resumes Services To The Quigley Corporation's Pharma Subsidiary 2Health News:Dr. Richard Rosenbloom Resumes Services To The Quigley Corporation's Pharma Subsidiary 3
(Date:12/24/2014)... RALEIGH, N.C. , Dec. 23, 2014 ... plc (NASDAQ: ENDP ) (TSX: ENL), and ... announced today that they have submitted a New Drug ... U.S. Food and Drug Administration (FDA).  Buprenorphine HCl Buccal ... severe enough to require daily, around-the-clock, long-term opioid treatment ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has ... Glucose Market" report to their offering. ... insight focuses on the developments in the self-monitoring blood ... . Reimbursement analysis and the effects of competitive bidding ... 73 SMBG meters have been performed, based on the ...
(Date:12/22/2014)... and STOCKHOLM , Dec. ... (Sobi) and partner Auxilium Pharmaceuticals, Inc. today announced that ... of the European Medicines Agency (EMA) has adopted a ... histolyticum) for the treatment of adult men with Peyronie,s ... at least 30 degrees at the start of therapy. ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5US Self-monitoring Blood Glucose Market 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
... 2007 /PRNewswire/ -- Mersana, a,cancer therapeutics company, announced ... product candidate, XMT-1001, will,be presented in two posters ... of Cancer Research (AACR) taking place April,14-18th in ... can be,viewed online at the AACR website at ...
... 13, 2007 - Biogen Idec Inc.,(NASDAQ: BIIB) ... the,Academy of Managed Care Pharmacy's (AMCP) 2007 ... a cost-effective therapy in,multiple sclerosis (MS) when ... comprehensive analysis of medical and pharmacy,costs, the ...
Cached Medicine Technology:Mersana Therapeutics, Inc. to Present Preclinical Data on XMT-1001,at American Association of Cancer Research Annual Meeting 2New One-Year Pharmacoeconomic Study Shows Avonex is Cost-Effective,Relative to Other Interferon Therapies for Multiple Sclerosis 2New One-Year Pharmacoeconomic Study Shows Avonex is Cost-Effective,Relative to Other Interferon Therapies for Multiple Sclerosis 3
These flexible stone retrieval devices are reusable, 3 Fr in diameter, with a working length of either 60 cm or 115 cm...
... The Brasseler USA™ MicroLine™ Small Bone ... of operation while performing under the ... powered system developed for small bone ... Drill, Sagittal Saw (Extended Length Available), ...
... Drill, with hand throttle, 30,000 ... Built-in medium bur guard included, ... bur guards are also available. ... hand throttle (#1940) for use ...
... Electric Micro Drill, without hand ... of torque. Built-in medium bur ... extra-long (#1100-006) bur guards are ... with foot throttle (#6401-000), can ...
Medicine Products: