Navigation Links
Lactic acid found to fuel tumors
Date:11/20/2008

DURHAM, N.C., and BRUSSELS, BELGIUM A team of researchers at Duke University Medical Center and the Universit catholique de Louvain (UCL) has found that lactic acid is an important energy source for tumor cells. In further experiments, they discovered a new way to destroy the most hard-to-kill, dangerous tumor cells by preventing them from delivering lactic acid.

"We have known for more than 50 years that low-oxygen, or hypoxic, cells cause resistance to radiation therapy," said senior co-author Mark Dewhirst, DVM, Ph.D., professor of radiation oncology and pathology at Duke. "Over the past 10 years, scientists have found that hypoxic cells are also more aggressive and hard to treat with chemotherapy. The work we have done presents an entirely new way for us to go after them."

Many tumors have cells that burn fuel for activities in different ways. Tumor cells near blood vessels have adequate oxygen sources and can either burn glucose like normal cells, or lactic acid (lactate). Tumor cells further from vessels are hypoxic and inefficiently burn a lot of glucose to keep going. In turn, they produce lactate as a waste product.

Tumor cells with good oxygen supply actually prefer to burn lactate, which frees up glucose to be used by the less-oxygenated cells. But when the researchers cut off the cells' ability to use lactate, the hypoxic cells didn't get as much glucose.

For the dangerous hypoxic cells, "it is glucose or death," said Pierre Sonveaux, professor in the UCL Unit of Pharmacology & Therapeutics and lead author of the study, published in the Nov. 20 online edition of the Journal of Clinical Investigation. He formerly worked with Dr. Dewhirst at Duke.

The next challenge was to discover how lactate moved into tumor cells. Because lactate recycling exists in exercising muscle to prevent cramps, the researchers imagined that the same molecular machinery could be used by tumor cells.

"We disc
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-323-0179
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
2. One Species Genome Found Within Another
3. National Patient Safety Foundation Partners with Vocera Communications
4. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
5. Patient Advocate Foundation Launches Program to Help Uninsured Virginians with Chronic, Debilitating and Life-Threatening Illness Access Quality Healthcare
6. AIDS Healthcare Foundation Applauds City Commissioners Support of Diversity, Urges Call for Mayors Resignation
7. National Osteoporosis Foundation Teams Up With Ladies Home Journal Magazine to Launch a 10-city Mall Walk Tour
8. Judge Rules That Florida Disease Management Program Serving 8,000 HIV/AIDS Patients Should Be Re-bid, Says AIDS Healthcare Foundation
9. The Tug McGraw Foundation Announces 2007 Fundraising Gala
10. The Arthur M. Blank Family Foundation Pushes for Pre-K Expansion in Georgia
11. Cipla, Tell the Truth; AIDS Healthcare Foundation Launches New Ad Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 6 Minutes to Skinny focuses on ... high gear with only a few minutes each day ... or lifestyle. This has caught the attention of HealthyandFitZone.com’s ... 6 Minutes to Skinny review shows that Craig ... understand exactly how your body responds to food and ...
(Date:7/24/2014)... ReNewLifeCleansing.com was inspired by ReNew Life ... “makeover.” While waging her battle with poor health, she ... for her recovery. She became an expert on cleansing, ... herbs, minerals, and other ingredients derived from nature help ... unwanted waste and toxins for better overall health. , ...
(Date:7/24/2014)... 24, 2014 The Republic of Tea, leading ... CARDAMOM CRÈME BRÛLÉE TEA to celebrate “The Hundred-Foot Journey,” a ... and Juliet Blake. A hundred-foot journey begins in the moment ... into a new realm that is far out of your ... physical distance that materially changes the course of your life ...
(Date:7/24/2014)... After waiting two years for her agonizing neck pain ... it was time to get her life back as she ... intervention was needed to bring her true relief. After diligent ... Center for help. Each staff member involved in her introduction ... Montana, the connection and security this Florida team created for ...
(Date:7/24/2014)... 2014 Debt Management Credit Counseling ... organization (DMCC), announced today that it is providing ... student loan borrowers identify and implement affordable repayment ... repayment options to borrowers who are struggling to ... the corresponding repayment terms, depend on many economic ...
Breaking Medicine News(10 mins):Health News:6 Minutes to Skinny: Review Examining Craig Ballantyne’s Weight Loss Program Released 2Health News:6 Minutes to Skinny: Review Examining Craig Ballantyne’s Weight Loss Program Released 3Health News:ReNew Life Launches New Educational Cleansing & Detox Website—ReNewLifeCleansing.com 2Health News:The Republic of Tea Unveils New Tea Inspired by “The Hundred-Foot Journey” 2Health News:The Republic of Tea Unveils New Tea Inspired by “The Hundred-Foot Journey” 3Health News:Nonprofit Debt Management Credit Counseling Providing Low Cost Student Loan Help 2Health News:Nonprofit Debt Management Credit Counseling Providing Low Cost Student Loan Help 3
... deployed worldwide to provide early detection of infectious disease ... that improve the overall detection capabilities of these systems ... systems do not hold up when there are shifts ... crises and major public events, such as the Olympic ...
... of Internal Medicine journal, Obese or overweight Chinese individuals ... developing tuberculosis than those at a normal weight. ... undernutrition in both developed and developing countries. In addition, ... a wide range of chronic degenerative conditions, notably, diabetes ...
... as selective serotonin reuptake inhibitors may be associated with ... and women. Selective serotonin reuptake inhibitors (SSRIs) treat ... neurotransmitter involved in sleep and depression. ,This ... raising the possibility that SSRIs may affect bone density ...
... University of Washington shows that the work intended for ... economy . ,The research was conducted by a ... Hagopian, professor in the School of Public Health and ... Initiative; and Sally Weatherford, finance and administration director of ...
... some experts believe C- section does not affect infants ... visit the doctor frequently early in life according to ... in the journal Epidemiology, Hong Kong researchers found that ... of hospitalization or outpatient visits during their first 18 ...
... Eubanks have won the 'World's Sexiest Vegetarians' title at PETA's annual ... the title, for she won the tag in 2005 as well. ... 'Tonight Show' band leader Eubanks, who bagged votes due to his ... 49-year-old and 'bring honour' to the show. ,The runners-up ...
Cached Medicine News:Health News:Obesity is Related to Lower Tuberculosis Risk 2Health News:Antidepressents may Lower Bone Density in Older People 2Health News:Antidepressents may Lower Bone Density in Older People 3Health News:Global Health Enriching the States Economy 2Health News:C- Section Does Not Affect an Infants Health 2
(Date:7/24/2014)... Mass. , July 24, 2014   ndd ... function testing (PFT) employing precise ultrasound technology, announced that ... the instrument to measure Carbon Monoxide Diffusing Capacity (DLCO) ... the most comprehensive study of Chronic Obstructive Pulmonary Disease ... cause of death in the U.S. and affects millions ...
(Date:7/23/2014)... N.Y. , July 23, 2014 ... of idelalisib to treat patients with relapsed chronic ... lymphocytic lymphoma (SLL) is a significant advance for ... Idelalisib, which goes by the trade name Zydelig®, ... protein that is highly expressed in many B-cell ...
(Date:7/23/2014)... MOUNTAIN VIEW, Calif. , July 23, 2014 ... translational preclinical research, today unveiled their new logo and ... transformation of Surpass, corporate culture to one where our ... This press release comes on the heels of the ... to the Silicon Valley Team:  David Craig, a veteran ...
Breaking Medicine Technology:EasyOne Pro from ndd Medical Technologies Chosen Again as the Exclusive PFT Testing Technology in Phase 2 of COPDGene Study 2The Leukemia & Lymphoma Society Applauds FDA's Approval of Idelalisib To Treat Three Types of Blood Cancers 2SURPASS Launches New Company Logo and Corporate Website, Symbolizing Transformation of Company Culture to Meet the Changing Needs of Clients in the Life Science Community Today. 2SURPASS Launches New Company Logo and Corporate Website, Symbolizing Transformation of Company Culture to Meet the Changing Needs of Clients in the Life Science Community Today. 3
... Feb. 15 Intra-Cellular Therapies, Inc. (ITI),announced ... its,first-in-class dual 5HT2A receptor antagonist/dopamine receptor,phosphoprotein modulator ... ITI,s family of compounds that inhibit a ... dysfunction in schizophrenia. Data,characterizing the pharmacological profile ...
... Plan Also Calls for Expansion of Business Development, Streamlining of ... ... Conference Call/Webcast at 11 a.m. EST Today -, LA JOLLA, Calif., ... strategic plan for 2008 with a focus,on clinical development activities to maximize ...
Cached Medicine Technology:Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders 2Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders 3Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders 4TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds 2TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds 3TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds 4TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds 5TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds 6
Each handle is designed to fit a specific trephine size....
... Centuries of German ... finest surgical instrumentation in ... makes them available to ... the coveted Meisterbrief certificate, ...
... of German Craftsmanship have ... instrumentation in the world. ... available to you! Only ... Meisterbrief certificate, which requires ...
... of German Craftsmanship have ... instrumentation in the world. ... available to you! Only ... Meisterbrief certificate, which requires ...
Medicine Products: