Navigation Links
Lack of social interaction affects health outcomes of breast cancer
Date:9/29/2009

PHILADELPHIA Social environment can play an important role in the biology of disease, including breast cancer, and lead to significant differences in health outcome, according to results of a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

"This study uses an elegant preclinical model and shows that social isolation alters expression of genes important in mammary gland tumor growth," said the journal's Deputy Editor Caryn Lerman, Ph.D. "It further elucidates the molecular mechanisms linking environmental stress with breast cancer development and progression."

These findings suggest novel targets for chemoprevention, and future studies should evaluate whether these molecular processes can be reversed by chemopreventive agents, according to Lerman, who is the Mary W. Calkins professor of psychiatry and scientific director of the Abramson Cancer Center at the University of Pennsylvania, Philadelphia.

Previous results from clinical studies have indicated that social support can improve the health outcome of patients with breast cancer. Epidemiological studies have suggested that social isolation increases the mortality risk from several chronic diseases.

Suzanne D. Conzen, M.D., associate professor in the department of medicine and the Ben May department for cancer research at the University of Chicago, along with colleagues from the Institute of Mind and Biology at the University of Chicago, evaluated whether an unfavorable social environment could influence tumor growth in mice that are genetically predisposed to mammary gland cancer.

They found that female mice that were chronically stressed because of social isolation (from the time they were first separated from their mothers) developed significantly larger mammary gland tumors compared to those mice that were group-housed.

Additionally, the isolated mice developed a heightened corticosterone stress hormone response.

"Despite the genetic similarity of the mice assigned to grouped versus isolated housing, living in the stressful environment was associated with greater tumor size, suggesting that the social environment may in fact alter the biology of cancer growththen, of course, the question becomes how," she said.

The researchers studied gene expression in the mouse mammary tissues and found that alterations in the expression levels of metabolic pathway genes, which are expected to favor increased tumor growth, had occurred in the isolated mice even before tumor size differences were measurable. These gene expression patterns suggest potential molecular biomarkers and/or targets for preventive intervention in breast cancer.

Further research is needed to focus on which specific cell types the changes in gene expression are taking place, according to Conzen. This knowledge could potentially lead to interventions that block similar pathways favoring the growth of human breast cancer.

"Given the increased knowledge of the human genome we can begin to objectively identify and dissect the specific alterations that take place in cancer-prone tissues of individuals in at-risk environments and that will help us to better understand and implement cancer prevention strategies," she concluded.

PRESS BRIEFING DETAILS:

Reporters can participate by using the following information on Sept. 29, 2009, at 1:00 p.m. ET:

U.S./Canada Dial In: (888) 282-7404
International: (706) 679-5207
Access ID: 29522076
Topic: AACR

The following leading scientists will address this exciting new research:

Scott M. Lippman, M.D.
Professor and Chair
Department of Thoracic/Head and Neck Medical Oncology
University of Texas M. D. Anderson Cancer Center
Editor-in-Chief
Cancer Prevention Research

Thea Tlsty, Ph.D.
Professor of Pathology
Director, Center for Translational Research in the Molecular Genetics of Cancer
Director, Program of Cell Cycling and Signaling
University of California San Francisco

Caryn Lerman, Ph.D.
Mary W. Calkins Professor
Department of Psychiatry
Scientific Director
Abramson Cancer Center
University of Pennsylvania

Suzanne D. Conzen, M.D.
Associate Professor in the Department of Medicine
Ben May Department for Cancer Research
The University of Chicago


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Dow Jones Sustainability Index Again Recognizes Abbott for Continued Leadership in Business, Environmental and Social Performance
2. Cognitive Activities Protect Against Alzheimers -- Social and Physical Activities Not Enough
3. MJGC Welcomes New Director of Social Work Alla Lerner
4. Civil Rights and Medical Leaders Call for Social Justice in Health Care
5. Multicountry review shows that Bug Buster Kits reduce head lice and social stigma
6. Hartford Foundation awards grant to address geriatric social work shortage
7. Study to consider social risk in guiding prevention of heart disease
8. IOM advisory: improving cancer patients psychosocial care
9. Cancer care providers need to proactively address patients psychological and social needs
10. Penn wins $5M to start center for ethical, legal and social implications research
11. Social Justice Issues Take Main Stage at Egypts National Democratic Party Convention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... AL (PRWEB) , ... December 02, 2016 , ... ... from across the Dothan-Wiregrass Area in Alabama are expected to attend the UNCF ... Schmitz, will help provide scholarship funds for area students and operating support to ...
(Date:12/2/2016)... ... December 02, 2016 , ... Center for Autism and Related ... those affected by autism spectrum disorder (ASD) and other developmental disabilities. The group, which ... give parents and other caregivers the opportunity to share stories and advice, seek help, ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of pain management programs ... patients must find the one that works for them. When an inventor from Suisun ... that worked and decided to share it with others. , He developed a prototype ...
(Date:12/2/2016)... York, NY (PRWEB) , ... December 02, 2016 , ... ... high school and while 84 percent of parents report speaking with their child about ... pornography and sexually transmitted diseases. , Mediaplanet is proud to announce the launch of ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd ... Beach Resort and Spa in Honolulu, offering local frontline clinicians the opportunity to ... , The demand for supplemental training related to pain management has surged ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 Research and Markets has announced the ... their offering. ... R&D Drug Pipeline Database: 1-Year ... Drug Pipeline Database provides 24/7 online access to information about more ... and on investigational drug candidates in research & development. ...
(Date:12/2/2016)... , December 2, 2016 bioLytical Laboratories, un líder mundial ... el INSTI HIV Self Test , a los miembros de la Kenya ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue ...
(Date:12/2/2016)...  LifeVac, the revolutionary device that has successfully rescued ... Training and Support Services (ERTSS) training programs. ... part of the ERTSS mission to save lives," said ... "Having an established network of expert trainers demonstrating how ... our efforts to spread LifeVac,s message that choking deaths ...
Breaking Medicine Technology: