Navigation Links
Lack of sleep found to be a new risk factor for aggressive breast cancers
Date:8/27/2012

Lack of sleep is linked to more aggressive breast cancers, according to new findings published in the August issue of Breast Cancer Research and Treatment by physician-scientists from University Hospitals Case Medical Center's Seidman Cancer Center and Case Comprehensive Cancer Center at Case Western Reserve University.

Led by Cheryl Thompson, PhD, the study is the first-of-its-kind to show an association between insufficient sleep and biologically more aggressive tumors as well as likelihood of cancer recurrence. The research team analyzed medical records and survey responses from 412 post-menopausal breast cancer patients treated at UH Case Medical Center with Oncotype DX, a widely utilized test to guide treatment in early stage breast cancer by predicting likelihood of recurrence.

All patients were recruited at diagnosis and asked about the average sleep duration in the last two years. Researchers found that women who reported six hours or less of sleep per night on average before breast cancer diagnosis had higher Oncotype DX tumor recurrence scores. The Oncotype DX test assigns a tumor a recurrence score based on the expression level of a combination of 21 genes.

"This is the first study to suggest that women who routinely sleep fewer hours may develop more aggressive breast cancers compared with women who sleep longer hours," said Dr. Thompson, who is Assistant Professor at Case Western Reserve University School of Medicine and lead author. "We found a strong correlation between fewer hours of sleep per night and worse recurrence scores, specifically in post-menopausal breast cancer patients. This suggests that lack of sufficient sleep may cause more aggressive tumors, but more research will need to be done to verify this finding and understand the causes of this association."

The authors point out that while the correlation of sleep duration and recurrence score was strong in post-menopausal women, there was no correlation in pre-menopausal women. It is well known that there are different mechanisms underlying pre-menopausal and post-menopausal breast cancers. The data suggest that sleep may affect carcinogenic pathway(s) specifically involved in the development of post-menopausal breast cancer, but not pre-menopausal cancer.

"Short sleep duration is a public health hazard leading not only to obesity, diabetes and heart disease, but also cancer," said Li Li, MD, PhD, a study co-author and family medicine physician in the Department of Family Medicine at UH Case Medical Center and Associate Professor of Family Medicine, Epidemiology and Biostatistics at Case Western Reserve University School of Medicine. "Effective intervention to increase duration of sleep and improve quality of sleep could be an under-appreciated avenue for reducing the risk of developing more aggressive breast cancers and recurrence."


'/>"/>

Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

Related medicine news :

1. Sleep improves memory in people with Parkinsons disease
2. Non-invasive treatment for children with obstructive sleep apnea suggested by Ben-Gurion University study
3. Sleep Apnea Affects Many Women, Too
4. Rhode Island Hospital study: Bariatric patients with obstructive sleep apnea fail to show symptoms
5. Sleep Loss Often Disruptive for City Kids With Asthma
6. Dont Trust Dr. Google for Help on Infant Sleep Safety
7. Sleepiness Hampers Job Performance, Study Confirms
8. Poor Sleep Hampers Vaccine Effectiveness: Study
9. Global sleeplessness epidemic affects an estimated 150 million in developing world
10. Sleep affects potency of vaccines
11. Work-Linked Sleep Loss May Harm Police Officers Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... Las Vegas, Nevada (PRWEB) , ... February 09, ... ... is now providing treatment to Medicaid beneficiaries who are diagnosed with autism spectrum ... state of Nevada. Autism treatment using applied behavior analysis (ABA) is key ...
(Date:2/9/2016)... ... February 09, 2016 , ... A ... fee schedule rates and Medicare rates for a variety of medical services in ... Evaluation of the 2015 Fee Schedule Rates in Illinois, are professional ...
(Date:2/9/2016)... York, NY (PRWEB) , ... February 09, 2016 , ... ... the appointment of Dr. David Hung to the company´s Board of Directors. ... a world class scientist and an exceptional entrepreneur.” said Juan Jose Chacon Quiros, CEO ...
(Date:2/9/2016)... ... February 09, 2016 , ... Dr. Rassouli, cosmetic ... Teeth whitening is among the most popular cosmetic procedures in dentistry today, but the ... This can put them at risk of teeth whitening-related damage. For a limited time, ...
(Date:2/9/2016)... ... 2016 , ... Two renowned photographers, Robert Caplin (New York, NY) and Peter ... June 14-19, 2016, hosted by Four Seasons Resort Maui at Wailea as part of ... in 2015, the Maui Photo Expedition workshop will once again consist of ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... new report "Global Diagnostic Ultrasound Devices Market Assessment & Forecast: 2015-2019" ... diagnostic ultrasound devices market was valued at US$ 5,381.1 million in ... at a CAGR of 6.8% from 2015 to 2019. The ... for six geographies of North America , ... Latin America , Middle-East and ...
(Date:2/9/2016)... The global prefilled syringes market accounted for $3,905.1 million ... with a CAGR of 12.9% during 2015-2020. Among the ... global prefilled syringes market, with 90.1% share in 2014. ... global market of prefilled syringes is up surging with ... demand for vaccines, increasing prevalence of chronic and lifestyle ...
(Date:2/9/2016)... report "Global Blood Monitoring & Cardiac Monitoring Devices Market Assessment & ... that global market for blood monitoring & cardiac monitoring devices was ... to US$ 24,830.1 million by 2019 at a CAGR of 6.8% ... Europe , Asia-Pacific , ... Africa . The three major factors determining growth ...
Breaking Medicine Technology: