Navigation Links
Lack of sleep affects bone health and bone marrow activity
Date:9/18/2012

Scientists at the Medical College of Wisconsin, in a team led by Carol Everson, Ph.D., professor of neurology, cell biology, neurobiology and anatomy, have discovered abnormalities in bone and bone marrow in rats undergoing chronic lack of sleep. They discovered abnormalities in serum markers of bone metabolism in sleep-deprived rats, which led them to conduct direct measurements of bone parameters; this time in rats experiencing recurrent sleep restriction during a large portion of their young adulthood.

The results show a dramatic imbalance between bone apposition and reabsorption, marked by an arrest in bone formation without reduced absorption. Furthermore, fat in the red marrow is greatly diminished and platelet-generating cells are doubled in number, indicating changes to marrow plasticity. "If the same processes are evoked in humans," said Dr. Everson, "the potential medical implications are far-reaching and may include poor repair of microdamage from activities of daily living, introduction of osteoporotic processes, and changes to progenitor cells that may affect disease predisposition and disease resistance."

The results appear in the September 2012 issue of Experimental Biology and Medicine. http://ebm.rsmjournals.com/content/237/9/1101.full. Co-authors of the paper are Jeffrey M. Toth, Ph.D., professor of orthopaedic surgery at the Medical College of Wisconsin, and Anne Folley, now a graduate student at George Washington University.

The researchers observed changes in intramembranous ossification and marrow hypercellularity resulting from chronic sleep loss. "Marrow fat was greatly diminished and reflected increased blood cell production and differentiation. Our findings of increased megakaryocyte numbers, for example, suggest that there is an increased demand for cell delivery to the circulation consistent with an inflammatory response, and conceivably the promotion of thrombocytosis," said Dr. Everson.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "With increased life stress due to work-related, financial and other issues a large percentage of us are experiencing difficulties in sleeping. While we know that chronic sleep loss can affect our health little specific information has been available on how it may impact bone formation or loss. Drs. Everson and Toth, together with Anne Folley present exciting results indicating that sleep deprivation in rats arrests new bone formation, decreases fat within the red marrow and increases platelet levels. If true in humans, and I expect that it may be, this work will have great impact on our understanding of the impact of sleep deprivation on osteoporosis and inability to repair bone damage as we age".


'/>"/>

Contact: Dr. Carol Everson
ceverson@mcw.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. UMass Amherst sleep researchers study value of preschool naps
2. Psych, Sleep Meds May Affect Driving
3. Puberty turned on by brain during deep sleep
4. Substantial road traffic noise in urban areas contributes to sleep disturbance and annoyance
5. Multiple Methods Can Safely Help Babies Get to Sleep, Study Shows
6. Bus, Truck Drivers May Downplay Sleep Troubles
7. Poor Sleep Among Preschoolers May Be Tied to Special Ed Needs Later
8. Sleep apnoea linked with increased risk of cancer death
9. Snoring Kids Should Be Screened for Sleep Apnea: Experts
10. You Can Learn While You Sleep, Study Suggests
11. Lack of sleep found to be a new risk factor for aggressive breast cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... Gym Source, America’s leading retailer ... showroom at South Dixie Hwy in Miami, FL. , “We are elated to be ... new innovative in-store concept is designed to give clients a seamless and motivating shopping ...
(Date:1/17/2017)... Los Angeles, CA (PRWEB) , ... January 17, ... ... conflicted and concerned by the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting ... tragedies and magical moments that help everyone endure and pass through tough times, ...
(Date:1/17/2017)... St. Petersburg, Florida (PRWEB) , ... January 17, 2017 , ... ... and the Producers of AsSeenOnTV.pro will be featuring DRTV campaigns regarding the topic of ... year to become a better version of themselves. What better way to commit to ...
(Date:1/17/2017)... CA (PRWEB) , ... January 17, 2017 , ... ... County, as well as Palm Desert, is opening a new office in San ... deep transcranial magnetic stimulation (dTMS) in Southern California, successfully treating individuals struggling with ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples Health is ... Health network on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, ... an exciting addition to our provider network, and the addition will benefit our ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 2017 Precision medicine is an emerging ... of disease. The approach allows doctors and physicians ... The approach studies the individual profile at a ... In January 2015, Precision Medicine Initiative (PMI) was ... with more than one million volunteers. All of ...
(Date:1/17/2017)... -- EU5 Glucose Monitoring Market Outlook to 2022 ... Market Outlook to 2022", provides key market data on ... in millions of US dollars, volume (in units) and ... Meters, Blood Glucose Test Strips and Lancets. The ... for each of these market segements, and global corporate-level ...
(Date:1/17/2017)... 17, 2017 The Global Nebulizers Market is ... over the next decade to reach approximately $1698.68 million ... market is witnessing include rapidly growing demand in emerging ... in nebulizer products and online marketing strategies by key ... is categorized into pneumatic nebulizers, ultrasonic nebulizers and mesh ...
Breaking Medicine Technology: