Navigation Links
Lack of sleep affects bone health and bone marrow activity
Date:9/18/2012

Scientists at the Medical College of Wisconsin, in a team led by Carol Everson, Ph.D., professor of neurology, cell biology, neurobiology and anatomy, have discovered abnormalities in bone and bone marrow in rats undergoing chronic lack of sleep. They discovered abnormalities in serum markers of bone metabolism in sleep-deprived rats, which led them to conduct direct measurements of bone parameters; this time in rats experiencing recurrent sleep restriction during a large portion of their young adulthood.

The results show a dramatic imbalance between bone apposition and reabsorption, marked by an arrest in bone formation without reduced absorption. Furthermore, fat in the red marrow is greatly diminished and platelet-generating cells are doubled in number, indicating changes to marrow plasticity. "If the same processes are evoked in humans," said Dr. Everson, "the potential medical implications are far-reaching and may include poor repair of microdamage from activities of daily living, introduction of osteoporotic processes, and changes to progenitor cells that may affect disease predisposition and disease resistance."

The results appear in the September 2012 issue of Experimental Biology and Medicine. http://ebm.rsmjournals.com/content/237/9/1101.full. Co-authors of the paper are Jeffrey M. Toth, Ph.D., professor of orthopaedic surgery at the Medical College of Wisconsin, and Anne Folley, now a graduate student at George Washington University.

The researchers observed changes in intramembranous ossification and marrow hypercellularity resulting from chronic sleep loss. "Marrow fat was greatly diminished and reflected increased blood cell production and differentiation. Our findings of increased megakaryocyte numbers, for example, suggest that there is an increased demand for cell delivery to the circulation consistent with an inflammatory response, and conceivably the promotion of thrombocytosis," said Dr. Everson.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "With increased life stress due to work-related, financial and other issues a large percentage of us are experiencing difficulties in sleeping. While we know that chronic sleep loss can affect our health little specific information has been available on how it may impact bone formation or loss. Drs. Everson and Toth, together with Anne Folley present exciting results indicating that sleep deprivation in rats arrests new bone formation, decreases fat within the red marrow and increases platelet levels. If true in humans, and I expect that it may be, this work will have great impact on our understanding of the impact of sleep deprivation on osteoporosis and inability to repair bone damage as we age".


'/>"/>

Contact: Dr. Carol Everson
ceverson@mcw.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. UMass Amherst sleep researchers study value of preschool naps
2. Psych, Sleep Meds May Affect Driving
3. Puberty turned on by brain during deep sleep
4. Substantial road traffic noise in urban areas contributes to sleep disturbance and annoyance
5. Multiple Methods Can Safely Help Babies Get to Sleep, Study Shows
6. Bus, Truck Drivers May Downplay Sleep Troubles
7. Poor Sleep Among Preschoolers May Be Tied to Special Ed Needs Later
8. Sleep apnoea linked with increased risk of cancer death
9. Snoring Kids Should Be Screened for Sleep Apnea: Experts
10. You Can Learn While You Sleep, Study Suggests
11. Lack of sleep found to be a new risk factor for aggressive breast cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... D.C. (PRWEB) , ... March 23, 2017 , ... ... (LEAD Coalition) stands with all Americans facing life-altering and fatal diseases in opposition ... budget makes shortsighted decisions that would eviscerate care, services, and hope for the ...
(Date:3/23/2017)... ... , ... The Boulevard is honored to host Shriners and Masons Children’s Day ... in the Main West Entrance of The Boulevard (in front of JCPenney). , ... and each child with a parent or guardian will be photographed for free and ...
(Date:3/23/2017)... ... 23, 2017 , ... “Wounded Woman Be Ye Healed-Passing On A Legacy”: a ... Legacy” is the creation of published author, Desiree M Webb, a registered nurse, minister ... has been happily married to her husband, Paul, for over twenty-nine years. Desiree ...
(Date:3/23/2017)... ... March 23, 2017 , ... “The Trainer”: an electrifying ... author, Scotty, a fiction writer with an active imagination and an enthusiasm for action ... follows the tale of Wild Bill Hart, who sat looking at the thirty-three notches ...
(Date:3/22/2017)... ... March 22, 2017 , ... Cosmetic Town, ... first issue of its companion print magazine. The new magazine, scheduled for release ... to information provided by board-certified doctors from across the country. , According to ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...   Casetabs , the pioneer surgery coordination application, ... the iPhone. With this new release, Casetabs is further ... physician offices, ambulatory surgery centers (ASCs) and hospitals. The ... even faster, more reliable access to case information. ... connect care teams so that surgeries can be coordinated ...
(Date:3/23/2017)... FRANCISCO , March 23, 2017 ... a value of USD 25.7 billion by 2025, according to ... are expected to grow at a faster rate due to ... rising awareness about various types of esthetic procedures used for ... these disorders. Hence, they are considered as the highest revenue ...
(Date:3/23/2017)... NeuroVive Pharmaceutical AB (Nasdaq Stockholm: NVP, OTCQX: NEVPF), ... of the Annual report for 2016 is now available on ... ... Pharmaceutical AB is a leader in mitochondrial medicine. The company ... preserve mitochondrial integrity and function in areas of unmet medical ...
Breaking Medicine Technology: