Navigation Links
Lack of cellular enzyme triggers switch in glucose processing
Date:1/21/2010

n a series of experiments in mouse cells, the researchers showed that SIRT6-deficiency hypoglycemia is caused by increased cellular uptake of glucose and not by elevated insulin levels or defects in the absorption of glucose from food. They then found increased levels of glycolysis and reduced mitochondrial respiration in SIRT6-knockout cells, something usually seen when cells are starved for oxygen or glucose, and showed that activation of the switch from cellular respiration to glycolysis is controlled through SIRT6's regulation of a protein called HIF1alpha. Normally, SIRT6 represses glycolytic genes through its role as a compactor of chromatin the tightly wound combination of DNA and a protein backbone that makes up chromosomes. In the absence of SIRT6, this structure is opened, causing activation of these glycolytic genes. The investigators' finding increased expression of glycolytic genes in living SIRT6-knockout mice which also had elevated levels of lactic acid, characteristic of a switch to glycolytic glucose processing supported their cellular findings.

Studies in yeast, worms and flies have suggested a role for sirtuins in aging and longevity, and while much of the enzymes' activity in mammals is unclear, SIRT6's control of critical glucose-metabolic pathways could signify a contribution to lifespan regulation. Elevated glycolysis also is commonly found in tumor cells, suggesting that a lack of SIRT6 could contribute to tumor growth. Conversely, since knocking out SIRT6 causes blood sugar to drop, limited SIRT6 inhibition could be a novel strategy for treating type 2 diabetes.

"There's a lot we still don't know about SIRT6," adds Mostoslavsky, who is an assistant professor of Medicine at Harvard Medical School. "We need to identify the factors that interact with SIRT6 and determine how it is regulated; investigate whether it acts as a tumor suppressor and how it might help lower glucose levels in diabetes; and determine its
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Key to Hepatitis C May Be Two Cellular Proteins
2. Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice
3. Louisiana's TCA Cellular Therapy's Findings Reported at World Stem Cell Summit -- Patients' Legs Saved from Amputation Using Adult Stem Cells
4. To regenerate muscle, cellular garbage men must become builders
5. K-State biologist to further study of cellular process that plays role in chronic disease
6. Global Med Technologies(R), Inc. Announces Its First EdgeCell Cellular Therapy Software and EdgeLab/HLA Software Sale in North America
7. Sigma-Aldrich Offers Customizable Synthetic Extracellular Matrix for Stem Cell Research
8. Cellular Protein Yields Clues to Diabetes, Alzheimers
9. Cellular Technology Extends the Boundaries of E-healthcare, Says Frost & Sullivan
10. Video: New Online Film Introduces Longevinex Advantage(TM) -- The First Resveratrol-Based Dietary Supplement to Address Both Cellular and Connective Tissue Aging
11. Cellular telephones to expand knowledge of health behaviors and microorganisms in adolescent males
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014 For nearly 20 years, June ... babies, graces, and all of life's rites of passage. ... Nancy Tupper Ling, in Toasts: The Perfect Words ... , Organized by category and containing many original ... anywhere else, this timely tome contains sayings famous and ...
(Date:12/24/2014)... December 24, 2014 Attorneys handling talcum ... an update to their website, the Talcum Powder ... between talcum powder class action lawsuits and ovarian cancer ... and ovarian cancer updates at their website, which serves ... for ovarian cancer claims are not the same as ...
(Date:12/24/2014)... Dr. Ronald Receveur, a New Albany ... dental implants in a day, has written a ... teeth-whitening treatments. , In his blog published Dec. ... writes that overusing teeth-whitening treatments can lead to tooth ... , “Because teeth-whitening treatments are available in ...
(Date:12/24/2014)... Thompson HealthDay Reporter TUESDAY, ... the experimental Ebola vaccine that U.S. officials are preparing to ... precursor of that vaccine produced a safe and potent immune ... when given to more than 100 Ugandans in 2009 and ... that could potentially protect a person against infection by Ebola, ...
(Date:12/24/2014)... -- Long-term fear of terrorists may damage your heart and ... from Israel suggests. , , Conducted by researchers from the ... Israel, the threat of war and terrorism has been a ... wanted to test whether fear of terrorism can predict an ... author Hermona Soreq, a professor of molecular neuroscience, said in ...
Breaking Medicine News(10 mins):Health News:Talcum Powder Attorneys Explain Class Action Lawsuits 2Health News:Talcum Powder Attorneys Explain Class Action Lawsuits 3Health News:Talcum Powder Attorneys Explain Class Action Lawsuits 4Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 2Health News:New Albany Dentist Weighs In On New Trend of Overbleaching Teeth 3Health News:Early Study Offers Hope for an Ebola Vaccine 2Health News:Early Study Offers Hope for an Ebola Vaccine 3Health News:Early Study Offers Hope for an Ebola Vaccine 4Health News:Terrorism Fears May Shorten Your Life, Study Finds 2
... make the best use of the impasse in the US over ... global //hub in that sphere, scientist and entrepreneur Dr William J ... Corp, a leading biopharma and vaccine company in the US, was ... is participating in the BioAsia 2004 summit being held there. ...
... are in terminal decline because of global warming, scientists have ... year revealed that the rate of melting across the world ... glaciers in jeopardy. ,The loss of glaciers ... of millions of people within a few decades, experts warned. ...
... A new study reports that recent decline in breast cancer ... receptor (ER)-positive tumors and women younger than 70//. ... April 2 in the Journal of Clinical Oncology (JCO). ... average age of breast cancer diagnosis is 62. ...
... she wrote it off as just a part of growing ... month// .” ,“I was increasingly having painful menstrual ... 43. ,After running some tests, her doctor discovered ... in 10 women, usually of childbearing age. In addition to ...
... being led to believe that, if they get circumcised, ... a ‘vaccine;’ but it is not a vaccine// and ... false pretenses. ,“The century-old circumcision ‘experiment’ in ... Africa be any different?” asks Dan Bollinger, director of ...
... Prime Minister Girija Prasad Koirala who, despite his indifferent health ... coming to the SAARC summit. ,Addressing the opening ... statesman of Nepal, also used the occasion to confess to ... gambled 60 years of my political career to have a ...
Cached Medicine News:Health News:India Should Take the Lead in Stem Cell Research, Expert 2Health News:Bolivian Glacier Melts, Dangerously Fast 2Health News:Breast Cancer? ER Positive or Negative 2Health News:Hope for Ending the Pain, Infertility of Endometriosis? 2Health News:Hope for Ending the Pain, Infertility of Endometriosis? 3Health News:Promoting Circumcision to Prevent HIV is Misguided and Will Backfire: ICGI 2
(Date:12/24/2014)... 2014  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), ... the development of brachytherapy devices and medical isotopes ... it has filed a de novo ... for marketing clearance for its patented Y-90 RadioGel(TM) ... Food, Drug and Cosmetic Act (the "Act").  ...
(Date:12/24/2014)... 24, 2014 LifeScienceIndustryResearch.com ... Disposable Syringe Industry of 178 pages providing ... intelligence library. The 2014 Market ... is a professional and deep research report ... analysis, the report introduces Disposable Syringe basic ...
(Date:12/24/2014)... Ohio , Dec. 23, 2014   ... treatment decision support to healthcare providers for behavioral ... it has secured $30 million in equity financing ... Virginia C. Drosos , President and Chief Executive ... clinical adoption and development of Assurex Health,s ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4
... 2011 The CAQH® Universal Provider Datasource® (UPD®) ... as the go-to resource for complete and reliable ...  Three out of five licensed and practicing physicians ... service. About 7,000 additional providers are registering each ...
... 2011 Instrumentation Laboratory (IL) today announced the appointment ... effective May 1, 2011.  Mr. Benet began his career ... Vice President of Worldwide Marketing, Sales and Service.   ... Josep Manent who served as CEO since 1999.  Under ...
Cached Medicine Technology:900,000 Healthcare Providers Now Part of CAQH Universal Provider Datasource 2900,000 Healthcare Providers Now Part of CAQH Universal Provider Datasource 3Instrumentation Laboratory Appoints Ramon E. Benet New Chief Executive Officer 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: