Navigation Links
Lack of cellular enzyme triggers switch in glucose processing
Date:1/21/2010

A study investigating how a cellular enzyme affects blood glucose levels in mice provides clues to pathways that may be involved in processes including the regulation of longevity and the proliferation of tumor cells. In their report in the January 22 issue of Cell, a Massachusetts General Hospital (MGH)-based team of researchers describes the mechanism by which absence of the enzyme SIRT6 induces a fatal drop in blood sugar in mice by triggering a switch between two critical cellular processes.

"We found that SIRT6 functions as a master regulator of glucose levels by maintaining the normal processes by which cells convert glucose into energy," says Raul Mostoslavsky, MD, PhD, of the MGH Cancer Center, who led the study. "Learning more about how this protein controls the way cells handle glucose could lead to new approaches to treating type 2 diabetes and even cancer."

SIRT6 belongs to a family of proteins called sirtuins, which regulate important biological pathways in organisms from bacteria to humans. Originally discovered in yeast, sirtuins in mammals have been shown to have important roles in metabolic regulation, programmed cell death and adaptation to stress. SIRT6 is one of seven mammalian sirtuins, and Mostoslavsky's team previously showed that mice lacking the protein die in the first month of life from acute hypoglycemia. The current study was designed to investigate exactly how lack of SIRT6 causes this radical drop in blood sugar.

Normally cells convert glucose into energy through a two-step process. The first stage called glycolysis takes place in the cytoplasm, where glucose is broken down into an acid called pyruvate and a few molecules of ATP, the enzyme that provides the energy to power most biological processes. Pyruvate is taken into cellular structures called mitochondria, where it is further processed to release much greater amounts of ATP through a process called cellular respiration.

I
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Key to Hepatitis C May Be Two Cellular Proteins
2. Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice
3. Louisiana's TCA Cellular Therapy's Findings Reported at World Stem Cell Summit -- Patients' Legs Saved from Amputation Using Adult Stem Cells
4. To regenerate muscle, cellular garbage men must become builders
5. K-State biologist to further study of cellular process that plays role in chronic disease
6. Global Med Technologies(R), Inc. Announces Its First EdgeCell Cellular Therapy Software and EdgeLab/HLA Software Sale in North America
7. Sigma-Aldrich Offers Customizable Synthetic Extracellular Matrix for Stem Cell Research
8. Cellular Protein Yields Clues to Diabetes, Alzheimers
9. Cellular Technology Extends the Boundaries of E-healthcare, Says Frost & Sullivan
10. Video: New Online Film Introduces Longevinex Advantage(TM) -- The First Resveratrol-Based Dietary Supplement to Address Both Cellular and Connective Tissue Aging
11. Cellular telephones to expand knowledge of health behaviors and microorganisms in adolescent males
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently ... View website of AngelWeddingDress.com to find more details. ... online for a bridal party. AngelWeddingDress offers a variety ... Its maternity wedding dresses are specially designed for 2015. ...
(Date:1/22/2015)... 22, 2015 A new white paper ... and person-centeredness in the long-term care environment as well ... the continuum. The paper, “The Power of Person-Centeredness in ... and practices of the patient, resident and family experience ...
(Date:1/22/2015)... 20 years, Dr. David Cruz of Cruz Chiropractic Care ... about every type of injury that can result from car accidents ... years, the team at Doctors on Liens has been ... With the combined breadth of experience between the two, ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A ... Sports Medicine flagship journal Medicine & Science in ... before exercise may help reduce gastrointestinal (GI) problems ... , Participants in the double-blind, placebo-controlled study ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative ... design to treat specific body parts and muscle groups. , ... easy to use patented cold therapy machine with the innovative ... and muscle injuries. IsoComforter has become the industry leader ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... , WEDNESDAY, July 13 (HealthDay News) -- People ... but virtual reality- and physical reality-based therapies may provide ... research suggests. In conducting the study, scheduled for ... of Physical Medicine and Rehabilitation , researchers assigned tasks ...
... development assistance from the Georgia Tech Research Institute (GTRI) ... an Atlanta-based company is developing what it hopes will ... hundreds of millions of people who wear glasses or ... To be used by optometrists and ophthalmologists, the ...
... News) -- For patients taking the heart rhythm drug amiodarone ... incidents of thyroid dysfunction than the brand-name medication, researchers report. ... difference between the two drugs, according to the report released ... . Amiodarone, a drug used to control arrhythmia -- ...
... from two major HIV prevention trials announced favorable results of ... of these trials, the Partners PrEP Study, has provided the ... both studies will need to be fully evaluated before it ... major trial that is ongoing. Investigators for VOICE Vaginal ...
... , WEDNESDAY, July 13 (HealthDay News) -- A ... fight the H1N1 epidemic in 2009 may not have boosted ... all. Guillain-Barre is a rare disorder, which causes a ... weakness and even paralysis. In 1976, a vaccine used ...
... (OA) is a leading cause of disability in the ... to raise awareness and increase knowledge of OA among ... American Journal of Nursing and the National Association of ... in the Prevention and Management of Osteoarthritis" on Thursday, ...
Cached Medicine News:Health News:'Virtual Reality' May Help in Parkinson's Therapy 2Health News:R&D collaboration focuses on new system for measuring and improving human vision 2Health News:R&D collaboration focuses on new system for measuring and improving human vision 3Health News:R&D collaboration focuses on new system for measuring and improving human vision 4Health News:Generic, Brand-Name Heart Drugs Seem to Have Same Effect on Thyroid 2Health News:VOICE study will continue as it considers what action to take after results of 2 trials 2Health News:VOICE study will continue as it considers what action to take after results of 2 trials 3Health News:VOICE study will continue as it considers what action to take after results of 2 trials 4Health News:'Swine Flu' Shot May Be Cleared of Guillain-Barre Charges 2Health News:State of the Science in the Prevention and Management of Osteoarthritis-A Conference for Nurses 2
(Date:1/23/2015)... 2015  CytoSorbents Corporation (NASDAQ CM: CTSO), a critical ... adsorber to reduce deadly inflammation in critically-ill and ... net of transaction costs, in non-dilutive funding as ... Certificate Transfer Program sponsored by the New Jersey ...
(Date:1/23/2015)... January 23, 2015 Heptares Therapeutics, the clinical-stage ... announce that the Malcolm Campbell Memorial Prize for ... President of Chemistry), Fiona Marshall (Chief Scientific Officer ... and co-founder) for the seminal contributions to GPCR drug discovery ...
(Date:1/22/2015)... 2015  BiOptix is pleased to announce the appointment of ... Chemistry and Biochemistry. Scott joins the company after previous scientific ... throughout the course of his nearly 20 year career ... a nationally recognized thought leader in the biosensor field ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2
... 2011 Zimmer Holdings, Inc. (NYSE: ZMH ; ... earnings conference call will be broadcast live over the Internet ...  A news release detailing the quarterly results will be made ... conference call. The live audio webcast can ...
... 2011 Lanx ® , Inc., a privately held ... devices for spinal surgery, today announced the launch of ... American Association of Neurological Surgeons (AANS) Annual Meeting, Denver, ... minimally invasive fixation alternative to pedicle screws, intended to ...
Cached Medicine Technology:Zimmer Holdings Announces Live Audio Webcast and Conference Call of First Quarter 2011 Results 2Lanx®, Inc. Announces Launch of Concero™ Facet Screw System for Spinal Fusion 2
Accepted by leading authorities as a simple and accurate method for discovering congenital color blindness of two type total color blindness and red/green blindness. This book is used for children an...
... MVR knife. 1.1 mm (19G) with a 1.38 ... Cannula (5/bx, 1 bx/ca). State-of-the-art manufacturing and quality ... precise. Sure grip handles have a ridge indicating ... fluid tight incision for self-sealing wounds. Gauge size ...
For use in cleaning soft contact lenses. Sensitive Eyes daily cleaner loosens and removes accumulations of film, deposits, and debris from soft contact lenses. Use with heat, chemical, and hydrogen p...
Complete Blink-N-Clean lens drops cleans and clears lenses in a blink. It is a unique blend of gentle to the eye ingredients that conveniently cleans, clears and keeps lenses feeling comfortable thro...
Medicine Products: