Navigation Links
Lack of cellular enzyme triggers switch in glucose processing
Date:1/21/2010

A study investigating how a cellular enzyme affects blood glucose levels in mice provides clues to pathways that may be involved in processes including the regulation of longevity and the proliferation of tumor cells. In their report in the January 22 issue of Cell, a Massachusetts General Hospital (MGH)-based team of researchers describes the mechanism by which absence of the enzyme SIRT6 induces a fatal drop in blood sugar in mice by triggering a switch between two critical cellular processes.

"We found that SIRT6 functions as a master regulator of glucose levels by maintaining the normal processes by which cells convert glucose into energy," says Raul Mostoslavsky, MD, PhD, of the MGH Cancer Center, who led the study. "Learning more about how this protein controls the way cells handle glucose could lead to new approaches to treating type 2 diabetes and even cancer."

SIRT6 belongs to a family of proteins called sirtuins, which regulate important biological pathways in organisms from bacteria to humans. Originally discovered in yeast, sirtuins in mammals have been shown to have important roles in metabolic regulation, programmed cell death and adaptation to stress. SIRT6 is one of seven mammalian sirtuins, and Mostoslavsky's team previously showed that mice lacking the protein die in the first month of life from acute hypoglycemia. The current study was designed to investigate exactly how lack of SIRT6 causes this radical drop in blood sugar.

Normally cells convert glucose into energy through a two-step process. The first stage called glycolysis takes place in the cytoplasm, where glucose is broken down into an acid called pyruvate and a few molecules of ATP, the enzyme that provides the energy to power most biological processes. Pyruvate is taken into cellular structures called mitochondria, where it is further processed to release much greater amounts of ATP through a process called cellular respiration.

I
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Key to Hepatitis C May Be Two Cellular Proteins
2. Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice
3. Louisiana's TCA Cellular Therapy's Findings Reported at World Stem Cell Summit -- Patients' Legs Saved from Amputation Using Adult Stem Cells
4. To regenerate muscle, cellular garbage men must become builders
5. K-State biologist to further study of cellular process that plays role in chronic disease
6. Global Med Technologies(R), Inc. Announces Its First EdgeCell Cellular Therapy Software and EdgeLab/HLA Software Sale in North America
7. Sigma-Aldrich Offers Customizable Synthetic Extracellular Matrix for Stem Cell Research
8. Cellular Protein Yields Clues to Diabetes, Alzheimers
9. Cellular Technology Extends the Boundaries of E-healthcare, Says Frost & Sullivan
10. Video: New Online Film Introduces Longevinex Advantage(TM) -- The First Resveratrol-Based Dietary Supplement to Address Both Cellular and Connective Tissue Aging
11. Cellular telephones to expand knowledge of health behaviors and microorganisms in adolescent males
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 20, 2014 As testosterone lawsuit ... federal court, Bernstein Liebhard LLP notes that advisors ... have voted overwhelmingly to recommend that prescription medications ... subjected to further study in order to investigate ... on September 18th by Bloomberg.com, the panel of ...
(Date:9/20/2014)... -- The avian flu that killed 160 harbor seals ... respiratory drops and therefore poses a potential threat to ... human illnesses have been linked to the harbor seal ... discovered natural mutations to the avian H3N8 seal virus ... in droplets. Current seasonal flu vaccines wouldn,t help ...
(Date:9/20/2014)... September 20, 2014 Ticket Down ... concert tickets for her 2015 “Honeymoon Tour.” This well-known ... for added savings. , In early 2015, fans will have ... the world across North America. Twenty-one-year-old Ariana Grande will hit ... will take her to 25 cities across the United States ...
(Date:9/20/2014)... September 20, 2014 iFitDress.com, the popular ... for women, has recently unveiled its new collection of ... sale for special offer on these new outfits; it ... season. All customers can now buy cheap cocktail ... company’s sales representative says, “We have extensive experience in ...
(Date:9/20/2014)... Traditionally dentists have advised their patients against drinking coffee ... is re-visiting that advice and changing his stance after considering ... have on oral health. “There’s good news and great news,” ... beneficial in protecting against gum disease, and red wine can ... was from the September 2014 issue of Boston University ...
Breaking Medicine News(10 mins):Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Avian Flu In Harbor Seals Could Infect People 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 3Health News:Fashionable Cocktail Dresses Unveiled Online at iFitDress.com 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3
... life stress could be a risk factor for cardiovascular ... life stress increases sensitivity to a hormone known to ... in adult life," said Dr. Jennifer Pollock, biochemist in ... Georgia and corresponding author on the study published online ...
... ... , ... 9, 2010 -- The national leading non-profit provider of services for individuals with autism ... experts from across the country along with other members of the autism community to ...
... lost much more weight than peers who tried lifestyle ... obese teens who received gastric banding surgery lost significantly ... as dieting and exercise, Australian researchers report. , Their ... a body-mass index (BMI) higher than 35 (statistical obesity ...
... , SAINT PAUL, Minn. , Feb. 9 ... (COPD), is now being measured by the Minnesota Department of Health,s ... causes of hospitalizations in Minnesota that can be triggered ... outdoor air pollution — asthma, heart attacks and COPD. , ...
... , Feb. 9 In conjunction with the 2010 ... (LSI) sponsored the first-annual Gridiron Greats Night of Champions, a ... Mike Ditka and Jamie Foxx . Supported by more ... non-profit organization that provides financial assistance and social services to retired ...
... the Ireland Cancer Center of University Hospitals (UH) Case ... to a new standard of care for patients with ... February issue of Clinical Cancer Research, the ... Triapine, was well tolerated in combination with standard-of-care cisplatin ...
Cached Medicine News:Health News:Early life stress may predict cardiovascular disease 2Health News:Local Carrollton Center Hosting More than 50 Autism Experts from Coast-to-Coast 2Health News:Gastric Banding Most Effective for Obese Teens 2Health News:Minnesota Department of Health Report: Nearly 6,000 Hospitalizations for COPD in 2007 2Health News:Laser Spine Institute Honored at the Gridiron Greats Night of Champions 2
(Date:9/19/2014)... Harwood Feffer LLP ( www.hfesq.com ) is ... PDL BioPharma, Inc. ("PDL" or the "Company") (Nasdaq: ... its fiduciary duties to shareholders or violated the federal ... Company disclosed: "On September 11, 2014, [PDL] was orally ... Young LLP ("EY"), that it was resigning effective September ...
(Date:9/19/2014)... Sept. 19, 2014 /PRNewswire-iReach/ -- Market Research ... Industry, 2009-2019 is a professional and in-depth ... Hydrochloride industry. The report firstly reviews the ... classification, application and manufacturing technology. The report ... of Oxybutynin Hydrochloride listing their product specification, ...
(Date:9/19/2014)... , Sept. 19, 2014  The board of directors ... a quarterly cash dividend of $0.42 per share.  ... 2014 to stockholders of record at the close of ... AbbVie is a global, research-based biopharmaceutical company formed in ... to use its expertise, dedicated people and unique approach ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5
... Jan. 28, 2011 Awarepoint Corporation, a privately ... 2010 with 91 hospital sites contracted consisting of ... (RTLS) network coverage in U.S. hospitals and 135,265 ... largest enterprise-wide U.S. hospital client base for RTLS ...
... NATICK, Mass., Jan. 28, 2011 Boston Scientific Corporation ... afternoon, the Civil Division of the U.S. Department of ... against Boston Scientific, Guidant LLC and other entities.  This ... of PRIZM™ 2 and RENEWAL® implantable cardioverter defibrillators (ICDs). ...
Cached Medicine Technology:Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 2Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 3Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 4Boston Scientific Responds to DOJ Civil Lawsuit 2Boston Scientific Responds to DOJ Civil Lawsuit 3
Hunt tumor grasping forceps....
Micro 2000 suture forceps light-weight instruments with blue-colored anodized round handles, extremely light weight, well balanced, easy to handle, fatigueless working, easy to maintain, corrosion-re...
Micro dressing forceps....
Round tip, sharp all around, angled....
Medicine Products: