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Labopharm To Present Poster On Onset Of Analgesic Effect Of Once-Daily Tramadol At Congress Of The European Society Of Regional Anaesthesia And Pain Therapy
Date:9/14/2007

clinical study MDT3-005, "A Comparison of the Analgesic Efficacy of Tramadol Contramid OAD Versus Placebo in Patients with Pain Due to Osteoarthritis" has been published in the September 2007 edition of the Journal of Pain and Symptom Management (Vol. 34, # 3, Pages 328-338).

The article discusses the results of clinical trial MDT3-005, a multi-center, randomized, double-blind, parallel study designed to assess the analgesic efficacy and safety of Labopharm's once-daily formulation of tramadol compared to placebo in patients with osteoarthritis of the knee. An absolute mean reduction of 3.0 +/- 2.1 on an 11-point Pain Intensity Numerical Rating Scale (PI-NRS) was noted in the Labopharm once-daily tramadol treatment group. The difference between active and placebo groups was statistically significant (P less than 0.001). The responder analysis demonstrated that a significantly greater percentage of patients in the active treatment arm achieved clinical pain relief (a reduction greater than or equal to 2 points on the PI-NRS score) by the end of the study (P equals 0.035). A significantly greater percentage of respondents in the Labopharm once-daily tramadol group indicated improvement on both the Patient and Physician Global Impressions of Change (P equals 0.0002). Both the 200 mg and 300 mg doses contributed to the overall superiority of Labopharm's once-daily tramadol. The most frequent adverse events were consistent with the known side effects of tramadol and were generally mild to moderate in intensity. The article concludes that the results of the study confirm that Labopharm's once-daily tramadol given once daily is an efficacious and safe treatment for pain due to osteoarthritis.

An online version of the article is available for download at http://www.sciencedirect.com (fee of US$30).

Labopharm Secures Partner for Once-Daily Tramadol in Israel

Labopharm also announced that it has
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SOURCE Labopharm Inc.
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