Navigation Links
Lab Study Finds Protein That May Inhibit Cancer Spread
Date:6/23/2009

Tests in mice show prosaposin injections reduce tumor growth

MONDAY, June 22 (HealthDay News) -- A protein produced by certain kinds of tumors inhibits the spread of cancer and could potentially be harnessed as a cancer treatment, researchers say.

Currently, there is no approved therapy for inhibiting or treating metastasis -- the migration of cancer cells from the original cancer site to other parts of the body. Metastasis is one of the leading causes of cancer death.

Researchers at Children's Hospital Boston had found previously that metastatic tumors prepare "landing places" for cancer in other organs by secreting certain proteins that encourage tumor growth and attract feeder blood vessels. In the new study, they found that non-metastatic tumors secrete a protein called prosaposin that inhibits metastasis by promoting production of factors that block the growth of blood vessels, according to a news release from the hospital.

Laboratory tests showed that high levels of prosaposin were secreted by non-metastatic, localized prostate and breast tumors but that metastatic tumors secreted very little of the protein. The researchers then added prosaposin to highly metastatic tumor cells and injected them into mice.

Lung metastases in the mice were reduced by 80 percent, lymph node metastases disappeared, and there was a significant increase in survival time, the researchers found.

When prosaposin was injected directly into mice after they'd been injected with tumors cells, there was a large reduction in lung metastases and the mice lived at least 30 percent longer than those who didn't receive prosaposin, the study reported.

Further research revealed that prosaposin stimulated activity of the tumor suppressor p53 in connective tissue (stroma) surrounding the tumor, which then stimulated production of an inhibitor of blood vessel growth in the tumor stroma and in distant cells, according to the study.

"Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, might be an effective way to inhibit the metastatic process in humans," Randolph S. Watnick, an assistant professor in the Vascular Biology Program at Children's Hospital Boston, said in the news release.

The study appears online in Proceedings of the National Academy of Sciences.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, June 22, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lab Study Finds Protein That May Inhibit Cancer Spread
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical Officer ... physician colleagues, skilled nursing facility medical directors and other clinicians at various events ... Care." , "At many of these conferences we get to educate other physicians, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
Breaking Medicine Technology: