Navigation Links
Lab Study Finds Protein That May Inhibit Cancer Spread
Date:6/23/2009

Tests in mice show prosaposin injections reduce tumor growth

MONDAY, June 22 (HealthDay News) -- A protein produced by certain kinds of tumors inhibits the spread of cancer and could potentially be harnessed as a cancer treatment, researchers say.

Currently, there is no approved therapy for inhibiting or treating metastasis -- the migration of cancer cells from the original cancer site to other parts of the body. Metastasis is one of the leading causes of cancer death.

Researchers at Children's Hospital Boston had found previously that metastatic tumors prepare "landing places" for cancer in other organs by secreting certain proteins that encourage tumor growth and attract feeder blood vessels. In the new study, they found that non-metastatic tumors secrete a protein called prosaposin that inhibits metastasis by promoting production of factors that block the growth of blood vessels, according to a news release from the hospital.

Laboratory tests showed that high levels of prosaposin were secreted by non-metastatic, localized prostate and breast tumors but that metastatic tumors secreted very little of the protein. The researchers then added prosaposin to highly metastatic tumor cells and injected them into mice.

Lung metastases in the mice were reduced by 80 percent, lymph node metastases disappeared, and there was a significant increase in survival time, the researchers found.

When prosaposin was injected directly into mice after they'd been injected with tumors cells, there was a large reduction in lung metastases and the mice lived at least 30 percent longer than those who didn't receive prosaposin, the study reported.

Further research revealed that prosaposin stimulated activity of the tumor suppressor p53 in connective tissue (stroma) surrounding the tumor, which then stimulated production of an inhibitor of blood vessel growth in the tumor stroma and in distant cells, according to the study.

"Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, might be an effective way to inhibit the metastatic process in humans," Randolph S. Watnick, an assistant professor in the Vascular Biology Program at Children's Hospital Boston, said in the news release.

The study appears online in Proceedings of the National Academy of Sciences.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, June 22, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lab Study Finds Protein That May Inhibit Cancer Spread
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
Breaking Medicine Technology: