Navigation Links
Lab Study Finds Protein That May Inhibit Cancer Spread
Date:6/23/2009

Tests in mice show prosaposin injections reduce tumor growth

MONDAY, June 22 (HealthDay News) -- A protein produced by certain kinds of tumors inhibits the spread of cancer and could potentially be harnessed as a cancer treatment, researchers say.

Currently, there is no approved therapy for inhibiting or treating metastasis -- the migration of cancer cells from the original cancer site to other parts of the body. Metastasis is one of the leading causes of cancer death.

Researchers at Children's Hospital Boston had found previously that metastatic tumors prepare "landing places" for cancer in other organs by secreting certain proteins that encourage tumor growth and attract feeder blood vessels. In the new study, they found that non-metastatic tumors secrete a protein called prosaposin that inhibits metastasis by promoting production of factors that block the growth of blood vessels, according to a news release from the hospital.

Laboratory tests showed that high levels of prosaposin were secreted by non-metastatic, localized prostate and breast tumors but that metastatic tumors secreted very little of the protein. The researchers then added prosaposin to highly metastatic tumor cells and injected them into mice.

Lung metastases in the mice were reduced by 80 percent, lymph node metastases disappeared, and there was a significant increase in survival time, the researchers found.

When prosaposin was injected directly into mice after they'd been injected with tumors cells, there was a large reduction in lung metastases and the mice lived at least 30 percent longer than those who didn't receive prosaposin, the study reported.

Further research revealed that prosaposin stimulated activity of the tumor suppressor p53 in connective tissue (stroma) surrounding the tumor, which then stimulated production of an inhibitor of blood vessel growth in the tumor stroma and in distant cells, according to the study.

"Prosaposin, or derivatives that stimulate p53 activity in a similar manner in the tumor stroma, might be an effective way to inhibit the metastatic process in humans," Randolph S. Watnick, an assistant professor in the Vascular Biology Program at Children's Hospital Boston, said in the news release.

The study appears online in Proceedings of the National Academy of Sciences.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, June 22, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lab Study Finds Protein That May Inhibit Cancer Spread
(Date:6/27/2016)... ... June 27, 2016 , ... ... authorized OSHA Training Institute Education Center headquartered in Northern California, has issued an ... extreme heat at their worksites. Employers with workers exposed to high temperatures ...
(Date:6/27/2016)... ... 27, 2016 , ... "FCPX editors can now reveal their media with growing ... said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings ... users can now reveal the media of their split screens with growing colorful panels. ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... announced its strategic partnership with Connance, a healthcare industry leader providing predictive ... proven, proprietary technology combine to provide health systems, hospitals and ambulatory surgical ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... SYDNEY , June 26, 2016 One of ... , has announced the formation of a new biotechnology company, Noxopharm ... raise $6m in an IPO and to list on the ASX. ... drug candidate, NOX66, ready to enter a Phase 1 clinical study ... been designed to address one of the biggest problems facing cancer ...
(Date:6/26/2016)... June 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as ... Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) ... Daylight Time). As previously announced on May ... definitive merger agreement under which Jazz Pharmaceuticals has commenced ...
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
Breaking Medicine Technology: