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LSUHSC study finds early predictors of metabolic syndrome in healthy 7-9 year-olds
Date:7/12/2010

n part, to pre-and post natal factors that are modified by current physical activity. Therefore, race, low or high pregnancy weight and/or birth weight, and low physical activity collectively create a phenotype for poor metabolic function leading to increased risk for insulin resistance in young children.

"Although some of the risk factors cannot be changed, pregnancy weight, birth weight, and physical activity can all be modified and are targets for early intervention to prevent or delay insulin resistance and reduce the risk for metabolic syndrome," noted Dr. Sothern, who is the study's principal investigator.

The research team which also included Drs. Stuart Chalew, LSUHSC Professor of Pediatrics and Head of Pediatric Endocrinology, William Cefalu, Professor and Chief of Endocrinology, Stewart Gordon, Professor of Pediatrics, Julia Volaufova, Professor of Biostatistics, and LSUHSC Research Associate Brian Bennett as well as scientists from the LSU Pennington Biomedical Research Center, the University of Wyoming, and the University of Alabama at Birmingham, concluded that prospective studies are needed to confirm these findings.

Metabolic syndrome is a group of risk factors linked to overweight and obesity that increase the incidence of heart disease, diabetes, and stroke. In general, a person with metabolic syndrome is twice as likely to develop heart disease and five times as likely to develop diabetes as someone without metabolic syndrome. According to the National Institutes of Health, metabolic syndrome is diagnosed when a person has at least three of the following risk factors: abdominal obesity, high triglycerides, low High Density Lipoprotein (HDL), high blood pressure, and high blood sugar. The development metabolic syndrome is closely associated with being overweight, lack of physical activity and genetics and ethnicity.

"A genetic predisposition for metabolic syndrome with risk factors occurring early in life makes it even more
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Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

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