Navigation Links
LSUHSC research shows emotional stress can change brain function

New Orleans, LA Research conducted by Iaroslav Savtchouk, a graduate student, and S. June Liu, PhD, Associate Professor of Cell Biology and Anatomy at LSU Health Sciences Center New Orleans, has shown that a single exposure to acute stress affected information processing in the cerebellum the area of the brain responsible for motor control and movement coordination and also involved in learning and memory formation. The work is published in the January 12, 2011 issue of The Journal of Neuroscience.

The researchers found that a five-minute exposure to the odor of a predator produced the insertion of receptors containing GluR2 at the connections (synapses) between nerve cells in the brain. GluR2 is a subunit of a receptor in the central nervous system that regulates the transfer of electrical impulses between nerve cells, or neurons. The presence of GluR2 changed electrical currents in the cerebellum in a way that increased activity and altered the output of the cerebellar circuit in the brains of mice.

Our ability to learn from experience and to adapt to our environment depends upon synaptic plasticity the ability of a neuron or synapse to change its internal parameters in response to its history. A change in the GluR2 receptor subunit has been observed both during normal learning and memory as well as during many pathological processes, including drug addiction, stress, epilepsy, and ischemic stroke. However, the effect of this change on neuronal function is not fully understood.

"Our results lead to the testable prediction that emotional stress could affect motor coordination and other cerebellum-dependent cognitive functions," notes Dr. Liu. "These results are also applicable to communication in other brain regions and circuits. A long term goal is to alleviate the burden of neurological disorders such as motor dysfunctions, drug addiction, PTSD, and stroke." Next steps include further research to improve our understanding of the role GluR2 insertion plays in normal learning and functioning of the brain, why some neurons contain GluR2-lacking receptors, but not others, and how that affects their role in brain function.


Contact: Leslie Capo
Louisiana State University Health Sciences Center

Related medicine news :

1. APA gives LSUHSC psychiatry gold award for program in St. Bernard schools after Katrina
2. LA Tumor Registry at LSUHSC awarded $12 million SEER contract by NCI
3. LSUHSC study finds early predictors of metabolic syndrome in healthy 7-9 year-olds
4. UNC researchers investigate estrogen to prevent depression and cardiovascular disease
5. Pier Paolo Pandolfi, M.D., Ph.D., to receive Pezcoller-AACR International Award for Cancer Research
6. Feast or famine: Researchers identify leptin receptors sidekick as a target for appetite regulation
7. International research team reports major findings in prevention and treatment of blood clots
8. UNC researchers inch closer to unlocking potential of synthetic blood
9. Men with macho faces attractive to fertile women, researchers find
10. Researchers pinpoint origin of deadly brain tumor
11. European Research Council awards advanced researcher grant to KIT botanist Holger Puchta
Post Your Comments:
(Date:11/27/2015)... ... , ... A simply groundbreaking television series, "Voices in America", which is hosted ... array of issues that are presently affecting Americans. Dedicated to providing the world with ... changing the subjects consumers focus on, one episode at a time. , In ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... successful and prominent nonprofit healthcare organizations in the country. They have overseen financial ... organizations, and helped advance the healthcare industry as a whole through their advocacy ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... to discuss bioavailability and the need to integrate dose form selection in early ... with OBN, the membership organization supporting and bringing together the UK’s emerging life ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel ... self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with ... work with any font, giving users limitless opportunities to stylize and create designs ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
(Date:11/26/2015)... 26, 2015 ... "2016 Future Horizons and Growth Strategies ... Market: Supplier Shares, Country Segment Forecasts, Competitive ... offering. --> ) has ... Future Horizons and Growth Strategies in the ...
(Date:11/26/2015)... 2015 ) has ... of High Viscosity Drugs" report to their ... the addition of the "Self Administration of ... --> Research and Markets ( ... "Self Administration of High Viscosity Drugs" report ...
Breaking Medicine Technology: