Navigation Links
LSUHSC research reveals Rx target for HPV, Hep C and related cancers
Date:4/10/2013

sult in Angelman's syndrome, a developmental condition characterized by severe mental retardation in children because the brain is unable to "learn" by adapting its nerve connections to outside stimuli. Other mutations that cause a duplication of the E6AP gene and increased activity are thought to cause some forms of inherited Autism Spectrum Disorder. In other tissues, the genetic program of the Human Papillomavirus produces an E6 viral protein following infection that hijacks the E6AP enzyme to target a different set of cells, not only ensuring the ability of the virus to replicate but causing uncontrolled growth resulting in benign skin tags, warts, or cervical cancer, depending on the site of infection. The Hepatitis C virus exploits a similar strategy to ensure its replication in the liver by expressing a different protein that redirects the function of E6AP, resulting in cirrhosis and liver cancer in the chronically infected.

The LSUHSC investigators used the ability of E6AP to form chains of ubiquitin as a window into the molecular function of the enzyme. The studies provide a description of the mechanism for the enzyme at the molecular level which provides potential strategies for designing drugs to block E6AP function in the case of the Human Papillomavirus and Hepatitis C virus. Because E6AP is similar to a larger family of related master regulators that control other cell functions, knowledge about it may also apply to future drug design for enzymes involved in many other diseases.

"The current work by Ronchi and Klein marks a major advance in our understanding of this important class of cell regulators and redefines more than 15 years of work in the field by other investigators," notes Dr. Haas.


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. LSUHSC research discoveries shed light on common STI
2. LSUHSC research provides new drug target for Her-2 related breast cancer
3. LSUHSC research finding keys to future obesity & related diseases
4. LSUHSCs Tilton awarded prestigious Hower Award
5. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
6. Fox Chase researchers find some lung cancers linked to common virus
7. Researchers confirm multiple genes robustly contribute to schizophrenia risk in replication study
8. Take a kidney transplant now or wait for a better one? Hopkins researchers create decision tool
9. UCLA researchers find potential link between auto pollution, some childhood cancers
10. American Cancer Society awards new research and training grants
11. Increased rates of hospitalization linked to elder abuse, Rush researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... On April 16, 2015, Harper’s Bazaar Magazine, in ... Marks ,” interviewed a UK dermatologist on the causes and ... are a type of scar that reportedly affects nearly 90% ... of the elsastin and collagen in the dermis, the dense ... mark removal with the Coolbeam protocol is one of our ...
(Date:4/27/2015)... 2015 Beckman Coulter is sponsoring a ... study the evolution of neural circuitry and swimming behavior ... the mechanisms by which analogous forms of swimming behavior, ... evolved independently in certain sea slug clades. The webinar ... April 30, 2015 at 8:00am PT. , Sea slugs ...
(Date:4/27/2015)... Humble, TX (PRWEB) April 27, 2015 Sitting ... legs to ache and feel tired, and for those whose ... such as receptionists and taxi cab drivers, or to be ... teachers and hairdressers, the discomfort can be more severe and ... tired, achy leg syndrome. Dr. Madaiah Revana of Northeast Houston ...
(Date:4/27/2015)... PA (PRWEB) April 27, 2015 FMC ... will exhibit its wide range of market leading ingredients ... May 7 in Geneva, Switzerland. Vitafoods Europe 2015 expects ... 100 countries showcasing the latest research in such areas ... nutrition. , FMC Health and Nutrition’s booth will ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 Telematics Berlin ... tier 1&2 suppliers, associations, CE players and the government ... has opened to the car. This year’s panel on ... DG-Move at the European Commission, is an opportunity to ... and define a European Automotive Security Standard for years ...
Breaking Medicine News(10 mins):Health News:Stretch Marks: The Latest Treatment Options for Stretch Mark Removal 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 2Health News:Beckman Coulter Genomics Presents Using Next-Gen Sequencing to Study the Evolution of Neural Circuitry 3Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 3Health News:FMC Health and Nutrition to Feature Epax® Brand Omega-3 Ingredients at Vitafoods Europe 2015 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 3
... 25 Smart Balance Inc.,(Nasdaq: SMBL ) will ... on Wednesday, May 21, 2008, at the Teaneck Marriott ... 07666. Stockholders of record,at the close of business on ... all matters that properly come before the meeting., ...
... passed the Genetic Information Nondiscrimination Act (GINA) on April 24, ... which passed the House April 25, 2007 by a vote ... measure again quickly before sending it to President Bush to ... wait, Americans can now be confident that their genetic information ...
... A Johns Hopkins University biologist, in research with implications ... has determined that the eye uses light to reset ... ability to see. , The findings suggest that patients ... can be linked to lack of exposure to daylight ...
... InfoLogix, Inc.,(Nasdaq: IFLG ), a leading technology ... commercial industries, will release its,financial results for the ... 30th, 2008. Following the press release, President and ... Jay Roberts will,host a conference call with the ...
... had less blood loss, shorter hospital stays, study finds ... laparoscopic surgery to remove pancreatic tumors or cysts leads ... study finds. , In laparoscopic surgery, doctors make ... progress with fiber optics and video cameras. This less ...
... (OTC Bulletin,Board: NTRZ), a world leader in stabilized ... that it has entered into,definitive agreements to sell ... of $20,000,000. The offering is made,pursuant to the ... by,NutraCea with the Securities and Exchange Commission (the ...
Cached Medicine News:Health News:Genetic Information Nondiscrimination Act clears Senate 2Health News:Different processes govern sight, light detection 2Health News:InfoLogix to Report First Quarter Results on April 30, 2008 2Health News:Laparoscopic Surgery on Pancreas Has Fewer Complications 2Health News:NutraCea Announces $20 Million Securities Offering 2Health News:NutraCea Announces $20 Million Securities Offering 3
(Date:4/27/2015)... MILAN , April 27, 2015  USL di ... Italian province of Reggio Emilia, has implemented Zebra ... throughout the hospital. The Wireless Network Solution ... patients, medical records securely and in real time via ... available at all times. Zebra also provides employee and ...
(Date:4/27/2015)... SAN DIEGO , April 27, 2015  Agena Bioscience ... (CSP) for Agena Bioscience,s MassARRAY platform in China ... at unprecedented speed. It is a hotbed for practical, meaningful ... China and for the rest of the world. ... community in China ," said Peter ...
(Date:4/27/2015)... -- China Jo-Jo Drugstores, Inc. (NASDAQ CM: ... leading China-based retail and wholesale distributor that offers pharmaceutical ... pharmacies, today announced its subsidiary, Hangzhou Jiuzhou Grand Pharmacy ... sales incentive agreement with Wyeth Pharmaceutical Company, Ltd. ("Wyeth"), ... of Pfizer Inc. (NYSE: PFE ) (the ...
Breaking Medicine Technology:Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 2Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 3Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 4Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 5Agena Bioscience Names Bioyong Technology as Fifth Certified Service Provider in China 2China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 2China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 3China Jo-Jo Drugstore Signed a New Sales Incentive Agreement with Wyeth Pharmaceutical, a Subsidiary of Pfizer 4
... Disease Week ... 2008, ... today that it has initiated the Phase 2 clinical,development program of MDX-1100, ... ulcerative colitis (UC) and,rheumatoid arthritis (RA). MDX-1100 could potentially treat UC and ...
... Thailand, May 9 An emergency,veterinary team from the ... stand-by in Thailand awaiting authority to enter cyclone struck,Myanmar ... of animals,that human survivors depend on for food and ... The Food and Agriculture,Organization of the United Nations (FAO) ...
Cached Medicine Technology:Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 2Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 3Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis 4Animals That Cyclone Survivors Depend on Need Help Now 2
Inquire...
Inquire...
Inquire...
The modular, high-end stereomicroscope; meets even the most critical demands in research and quality control provides high-contrast images with excellent depth of field and color fidelity...
Medicine Products: