Navigation Links
LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
Date:2/17/2009

New Orleans, LA Michael Lan, PhD, Professor of Pediatrics and Genetics at LSU Health Sciences Center New Orleans, is the senior author of a paper revealing the molecular mechanism of how a protein determines the fate of the cells that make and release insulin. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest, a paper in press currently available online, will be published in the Journal of Biological Chemistry, Vol. 284, Issue 9, 5574-5581, February 27, 2009.

Dr. Lan's laboratory is studying INSM1, a protein involved in the regulation of hormone- producing, or endocrine, cells. INSM1 plays a critically important role in the development of pancreatic beta cells the only cells in the body that secrete insulin. Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to make it.

In this study, the research group used pancreatic cancer cells to investigate the effects of INSM1 on cell cycle function. INSM1 is a transcription factor a protein that binds to specific sequences of DNA and controls the target gene expression or action. The researchers developed an inducible system to "turn on" INSM1 in pancreatic cancer cells and found that it resulted in a significant reduction in the cells' growth rate. They showed that the mechanism for this growth inhibition was due to an interaction between INSM1 and cyclin D1, an important cell growth promoting protein. Through the interaction between these two proteins, the growth of the tumor cells was impaired. Further, transplantation of these INSM1 on pancreatic tumor cells into mice showed the growth rate of these tumor cells was significantly inhibited compared to the control cells.

"Taken together, we
'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-452-9166
Louisiana State University Health Sciences Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. LSUHSCs England leads development of new testing guidelines for common nerve disorder
2. LSUHSCs Dr. Xiao Cheng Wu co-authors annual report to the nation on cancer
3. LSUHSCs Fontham makes history
4. LSUHSC public health contributes to estimate of HPV-related cancers
5. LSUHSC awarded grant to address nursing shortage
6. LSUHSC study finds high-dose HBO2 therapy extends survival window after cardiopulmonary arrest
7. LSUHSC inventor awarded patent for new procedure to detect cancer spread
8. LSUHSC dental school to be awarded top national honor
9. Cancer Researcher Dan Von Hoff, M.D. Advocates for "Context of Vulnerability," A Powerful New Paradigm for Targeted Drug Development
10. MU researcher demonstrates non-traditional therapy is effective as pain management
11. Weight loss improves fatty liver disease, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2009)...ps to eliminate triggers, experts advise , ...t Scrooges, but people with allergies and asthma c...s and need to take special steps to prevent sneezi... of Allergy, Asthma and Immunology (ACAAI). , Thos...o decorate with artificial plants, but both live a...
(Date:12/5/2009)Wind Turbines are popping up in the most unusual places, and to do everything from growing mushrooms, making wine to keeping prisoners in jail! , (PRWEB) December 5, 2009 -- W
(Date:12/4/2009)PEMBROKE, Bermuda, Dec. 4 Allied World Assurance,Company Holdings, Ltd (NYSE: AWH ) today announced that Scott Carmilani,President and Chief Executive Officer, and Jack Sennott, Executive Vice,Pres
(Date:12/4/2009)ANAHEIM, Calif., Dec. 4 Pamela Bowen, Chief Information Officer at Crescent Healthcare, was selected as a finalist for the "Chief Innovation Officer" Appy Award for transforming Crescent,s business w
(Date:12/4/2009)Working with mice, scientists at Johns Hopkins publishing in the December issue of Neoplasia have shown that a protein made by a gene called "Twist" may be the proverbial red flag that can accuratel
Breaking Medicine News(10 mins):Health News:Keep Asthma, Allergies at Bay for the Holidays 2Health News:Distributor Announces New Applications for Wind Turbines 2Health News:Distributor Announces New Applications for Wind Turbines 3Health News:Allied World to Present at the 2009 Goldman Sachs U.S. Financial Services Conference 2Health News:Crescent CIO '09 Dreamforce Conference Speaker and Award Finalist 2Health News:Potential new 'twist' in breast cancer detection 2Health News:Potential new 'twist' in breast cancer detection 3
... It is a fact that,Multi-Drug Resistant organisms ...trochemical medicines. According to the World Heal...s are responsible for needless increases,in hospit...ions to this growing problem., (Photo: http://ww...
...eflex Stock, the leading independent supplier of r...tions has today (October 1, 2008) launched a new c...uded in the new collections is Heritage Images, an...ommercially for the first time. , ...
...ed by researchers at Mayo Clinic shows that obese ... response to the weight loss drug sibutramine, whi...le or no weight. , The findings are published in ...sured the impact of two different dosage levels of...
...xoGen, Inc., a leader in the development of treatm...uries, announced today that the American Associati...stigious AATB accreditation. This accreditation af...ue. , ALACHUA, Fla. (Bus...
...Emergency Service,Center (DESC) is pleased to rele...e. DESC uses CHASERS to store and manage informati... Created by DESC, CHASERS is both proven and a wor...tains information on,over 70,000 clients served by...
...he second time in presidential debate history, a f...ale opponent. While Geraldine Ferraro broke new gr...male to be included as part of a major party ticke...evealing study by a University of Missouri researc...
Other Medicine News:Health News:Argentyn 23(R) Homeopathic First Aid Gel - Another World's First by Natural-Immunogenics Corp. for Healthcare Professionals 2Health News:Reflex Stock Launches Exciting New Editorial Image Collections to the Worldwide Publishing Industry 2Health News:Genes affect weight loss drug effectiveness 2Health News: AxoGen Awarded Accreditation from American Association of Tissue Banks : Decision Affirms AxoGen's Commitment to Safety and Ethicality in the Development and Distribution of AVANCE Nerve Graft for Treatment of Peripheral Nerve Injuries 2Health News: AxoGen Awarded Accreditation from American Association of Tissue Banks : Decision Affirms AxoGen's Commitment to Safety and Ethicality in the Development and Distribution of AVANCE Nerve Graft for Treatment of Peripheral Nerve Injuries 3Health News:Downtown Emergency Service Center Releases CHASERS, Free Software for Homeless Service Management and Beyond 2Health News:Downtown Emergency Service Center Releases CHASERS, Free Software for Homeless Service Management and Beyond 3Health News:Gender is a relative term in politics, MU study finds 2
(Date:12/4/2009)STREAMWOOD, Ill., Dec. 4 Shared Imaging, LLC, an independent provider of CT, MRI and PET/CT systems and service programs for hospitals and healthcare providers, is excited to announce it has received
(Date:12/4/2009)ANNAPOLIS, Md., Dec. 4 PharmAthene, Inc. (NYSE Amex: PIP ), a biodefense company developing medical countermeasures against biological and chemical threats, announced today that the Company is prese
(Date:12/4/2009)TARRYTOWN, N.Y., Dec. 4 Bayer Diabetes Care today announced the three grand prize winners of Bayer,s "Express Your Simple Win Creativity Contest." Nick Jonas, of the Jonas Brothers, selected the winn
Breaking Medicine Technology:Shared Imaging Earns The Joint Commission's Accreditation for Ambulatory Health Care 2PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 2PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 3PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 4PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 5PharmAthene Presents Animal Model Data for Valortim(R) at the 2009 BARDA Industry Conference / PHEMCE Stakeholders Workshop 6Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 2Bayer 'Express Your Simple Win Creativity Contest' Grand Prize Winners Announced 3New Lumension Endpoint Management and Security Suite To Deliver End to End Endpoint Management Capabilities 62352 1New Lumension Endpoint Management and Security Suite To Deliver End to End Endpoint Management Capabilities 62352 2New Lumension Endpoint Management and Security Suite To Deliver End to End Endpoint Management Capabilities 62352 3New Lumension Endpoint Management and Security Suite To Deliver End to End Endpoint Management Capabilities 62352 4New Lumension Endpoint Management and Security Suite To Deliver End to End Endpoint Management Capabilities 62352 5New Lumension Endpoint Management and Security Suite To Deliver End to End Endpoint Management Capabilities 62352 6Hobby Lobby Selects Concentra to Open Health Center 62350 1Hobby Lobby Selects Concentra to Open Health Center 62350 2Hobby Lobby Selects Concentra to Open Health Center 62350 3US Farms Inc Announces Marketing Agreement With Micro Lending Institution Angels In Action 62347 1US Farms Inc Announces Marketing Agreement With Micro Lending Institution Angels In Action 62347 2US Farms Inc Announces Marketing Agreement With Micro Lending Institution Angels In Action 62347 3
...eague,s historic Personhood Conference is featurin...earch and regenerative medicine. , , (Logo: htt...OGO ) , , Dr. Theresa Deisher, founder and CEO o...Pharmaceutical Institute, is speaking on over 17 y...ry, production and commercialization of human ther...
...x Foundation for Parkinson,s Research awarded abou... will test drugs already approved in other disease...son,s disease. Because both drugs being tested are...tential to move swiftly toward regulatory approval...ective in PD. , , One funded team will investigat...
Other Medicine Technology:Stem Cell Pioneer to Speak to A.L.L. Personhood Conference 2Michael J. Fox Foundation Awards $2.9 Million for Two New Parkinson's Disease Clinical Trials 2
... Orthosis Until now, laborious custom fabrication ...tability was limited and modifications in response...d cumbersome.,The GunSlinger evolved from two yea...ching hospital. This orthosis can be quickly adjus...
...gned for the functional management of grade I, II,...e-inflated aircell, the brace provides focused, pn... while supporting the arm and shoulder. A detachab...additional arm support and helps to unload the wai...
...to treat or help prevent lower extremity disorder..., foot drop, contractures and pressure necrosis at...s a comfortable wicking interface for the patient....ed into a vertical configuration when not needed o...
... ankle. This simple concept is the cornerstone of ... you lock the heel with our patent-pending Stablel...d comfort your patient will experience walking in ...the heel and supports the posterior aspect of the ...
Medicine Products: