Navigation Links
LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
Date:2/17/2009

New Orleans, LA Michael Lan, PhD, Professor of Pediatrics and Genetics at LSU Health Sciences Center New Orleans, is the senior author of a paper revealing the molecular mechanism of how a protein determines the fate of the cells that make and release insulin. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest, a paper in press currently available online, will be published in the Journal of Biological Chemistry, Vol. 284, Issue 9, 5574-5581, February 27, 2009.

Dr. Lan's laboratory is studying INSM1, a protein involved in the regulation of hormone- producing, or endocrine, cells. INSM1 plays a critically important role in the development of pancreatic beta cells the only cells in the body that secrete insulin. Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to make it.

In this study, the research group used pancreatic cancer cells to investigate the effects of INSM1 on cell cycle function. INSM1 is a transcription factor a protein that binds to specific sequences of DNA and controls the target gene expression or action. The researchers developed an inducible system to "turn on" INSM1 in pancreatic cancer cells and found that it resulted in a significant reduction in the cells' growth rate. They showed that the mechanism for this growth inhibition was due to an interaction between INSM1 and cyclin D1, an important cell growth promoting protein. Through the interaction between these two proteins, the growth of the tumor cells was impaired. Further, transplantation of these INSM1 on pancreatic tumor cells into mice showed the growth rate of these tumor cells was significantly inhibited compared to the control cells.

"Taken together, we provide evidence to support that INSM1 binds to cyclin D1, a critical factor in cell growth, and interrupts normal cellular proliferation," notes Dr. Lan. "Our study furthers our understanding of how to control islet cell growth in the culture system, which may ultimately benefit diabetes."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-452-9166
Louisiana State University Health Sciences Center
Source:Eurekalert

Related medicine news :

1. LSUHSCs England leads development of new testing guidelines for common nerve disorder
2. LSUHSCs Dr. Xiao Cheng Wu co-authors annual report to the nation on cancer
3. LSUHSCs Fontham makes history
4. LSUHSC public health contributes to estimate of HPV-related cancers
5. LSUHSC awarded grant to address nursing shortage
6. LSUHSC study finds high-dose HBO2 therapy extends survival window after cardiopulmonary arrest
7. LSUHSC inventor awarded patent for new procedure to detect cancer spread
8. LSUHSC dental school to be awarded top national honor
9. Cancer Researcher Dan Von Hoff, M.D. Advocates for "Context of Vulnerability," A Powerful New Paradigm for Targeted Drug Development
10. MU researcher demonstrates non-traditional therapy is effective as pain management
11. Weight loss improves fatty liver disease, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope For Heroes ... lives in military battle for the country. The nonprofit Hope For Heroes partnered ... programs that empower independence for disabled military veterans, as well as police, firemen, and ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia is a common ... long-term patient survival, reports a team of UPMC researchers in the largest study ... Journal of Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead ...
(Date:5/26/2016)... ... 2016 , ... MadgeTech will be showcasing its line of data logging ... at the MadgeTech headquarters. With products sold in more than 100 countries around the ... NASA. , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech data ...
(Date:5/26/2016)... NY (PRWEB) , ... May 26, 2016 , ... ... Hereditary Retinal Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June ... to the public. , Dr. Maisel, founder of Retina Group of New ...
(Date:5/26/2016)... ... May 26, 2016 , ... In an effort to provide hair restoration information to the ... users and those who do not use the app. Dr. Mohebi, the founder of Parsa ... Dr. Mohebi Live . , Dr. Mohebi says, “The positive response to the Snapchat ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25,2016 FDA 510(k) ... Cellvizio platform for urological and surgical applications ... inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... in the US with the 12 th ... Administration (FDA). This new FDA clearance covers Confocal ...
(Date:5/25/2016)...  Zymo Research Corp. announced today the final ... that help researchers obtain the most accurate and ... rapid growth of the study of microbiomes has ... methods to improve the reproducibility and quality of ... every step of the measurement process including collection ...
(Date:5/25/2016)... 2016  Granger Diagnostics today announced immediate availability of ... infections. This test ensures discovery of ALL bacteria, ... test requires only a simple swab of the wound ... G. Bostwick , MD, Chief Medical Officer, described ... "We are excited to make available, for the ...
Breaking Medicine Technology: