Navigation Links
LSUHSC research finds protein that protects cancer cells from chemo and radiation therapy
Date:3/24/2011

New Orleans, LA Research led by Daitoku Sakamuro, PhD, Assistant Professor of Pathology at LSU Health Sciences Center New Orleans and the LSUHSC Stanley S. Scott Cancer Center, has identified a protein that enables the activation of a DNA-repair enzyme that protects cancer cells from catastrophic damage caused by chemo and radiation therapy. This protein, called c-MYC oncoprotein, can initiate and promote almost all human cancers and discovering the role it plays in cancer treatment resistance may lead to advances that save lives. The work is published in the March 29, 2011 issue of Science Signaling, a publication of the American Association for the Advancement of Science. Although scientists have known that cancer cells can acquire resistance to DNA-damaging therapeutic agents, the genetic mechanisms through which this occurs have remained unclear until now.

Using the chemotherapy drug, cisplatin (which is commonly used as a first-line therapy for various cancers) to design a set of experiments, the research team found that the c-MYC oncoprotein increases cisplatin resistance by decreasing production of a c-MYC inhibitor called BIN1. BIN1 suppressed an enzyme essential for DNA repair, and the sensitivity of cancer cells to cisplatin depended upon BIN1 abundance. Overproducing the c-MYC oncoprotein repressed BIN1, blocking its life-saving action.

"Our study provides a potent and novel mechanism through which cancer acquires resistance to DNA damage," notes Dr. Sakamuro. "Inhibition of oncogenic c-MYC may provide an attractive strategy for cancer therapy in combination with DNA-damaging agents."

The researchers also propose that analyzing the levels of the c-MYC and BIN1 proteins or their mutational status may also serve as a valuable prognostic marker to determine whether a cancer will respond to an aggressive dose of therapeutic agents.

According to the American Cancer Society, about 1,529,560 new cancer cases were expected to be diagnosed in the United States in 2010, excluding noninvasive cancers as well as basal and squamous cell skin cancers. Cancer accounts for nearly one quarter of the deaths in the US with an estimated 569,490 cancer deaths expected last year.

"Our study will determine how we can re-sensitize malignant cancer cells to conventional DNA-damaging therapeutic agents and how we can minimize unnecessary side effects associated with cytotoxic chemo and radiation therapy," adds Dr. Sakamuro.


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related medicine news :

1. LSUHSC research shows emotional stress can change brain function
2. APA gives LSUHSC psychiatry gold award for program in St. Bernard schools after Katrina
3. LA Tumor Registry at LSUHSC awarded $12 million SEER contract by NCI
4. LSUHSC study finds early predictors of metabolic syndrome in healthy 7-9 year-olds
5. Researchers: Sexually active teens need confidential health care
6. Researchers develop a halometer that tests alterations in night vision
7. ESCEO-AMGEN Fellowship awarded to Swedish and Argentinean researchers
8. Mouse Sperm Successfully Grown in Lab, Researchers Say
9. Boston University School of Medicine professor receives award for quality of care research
10. Mayo Clinic researchers find cardiac pacing helps epilepsy patients with ictal asystole
11. Researchers explore new treatments to end OA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... Cosmetic Town, an online plastic ... cosmetic surgeries they perform on a daily basis. , The new video series ... they specialize in at their practices. , When asked about the new video ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... California effectively destroyed the construction site and threatened numerous homes and businesses nearby, ... article on NBCLosAngeles.com. Los Angeles Area consulting firm Fire Protection Group, ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Every year, ... invigorating and educational conference, InstructureCon. Each annual event is coupled with a dynamic theme ... with a James Bond theme, Mission: InstructureCon 0017. , To extend their partnership ...
(Date:7/24/2017)... PHILADELPHIA (PRWEB) , ... July 24, 2017 , ... ... Health , two organizations that already work hand-in-hand on an Innovation Collaboration program, ... transform the access, quality, experience and cost of the care members and patients ...
(Date:7/24/2017)... , ... July 24, 2017 , ... Anyone who uses ... a watermelon, nor would a pharmacist using that same scale to dispense medication. The ... health. , These illustrations show why it is important to have the right ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... Endo International plc (NASDAQ: ENDP ) will announce its ... its senior management team will host a conference call and webcast ... The dial-in number to access the call is U.S./ ... passcode is 45397076. Please dial in 10 minutes prior to the ... replay of the call will be available from August 8, 2017 ...
(Date:7/13/2017)...  New York City-based market research firm Kalorama Information notes ... of.  From new products to new costs, to the threat ... completed study, Potential Pipeline Disruptors . Among ... 1.  Age-Driven Growth - True Impact Moment Arriving   ... impact the growing population and, to a more extreme extent, ...
(Date:7/11/2017)... N.J. , July 11, 2017  Bayer has awarded ... eight countries as part of its prestigious Bayer Hemophilia Awards ... Hospital of Philadelphia and Uniformed Services ... are among the winners. Grant recipients were announced last ... and Hemostasis (ISTH) 2017 Congress, Berlin, Germany ...
Breaking Medicine Technology: