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LSUHSC research finding keys to future obesity & related diseases
Date:12/6/2012

function leading to increased risk for insulin resistance in young children.

"In order to fully capitalize on the wealth of data that we have successfully gathered and analyzed thus far, we feel it is essential that we establish a longitudinal group," says Dr. Sothern. "This will enable us to examine prospectively the development of obesity and metabolic dysfunction and its relationship to inflammation from puberty to adolescence in healthy, non-obese and obese children."

In the current research project, Dr. Sothern will be re-measuring BMI and also analyzing blood tests for metabolic and genetic parameters in 100 healthy obese and non-obese adolescents. Because obesity and the metabolic syndrome are associated with inflammation, Dr. Sothern's group will examine the role of genetically determined pro and anti-inflammatory compounds and the change in obesity and biomarkers from pre-adolescence to adolescence. Over the same period of time, they will also examine the contribution of social determinants such as stress, economic disadvantage, neighborhood deterioration, violence, diet, and physical activity environment that can modify these compounds. The researchers will factor in maternal pregnancy weight and whether or not participants were breast-fed and for how long, as well.

To date no studies have documented the progression of obesity, insulin resistance and inflammation through the pubertal period of development using objective measures in relation to molecular, social and behavioral determinants of health in multi-ethnic children and adolescents.

Correlating the molecular basis of the metabolic syndrome in developing children with the social determinants of health such as maternal stress, neighborhood deterioration, food and physical activity environment and behavioral factors, diet and exercise, is an innovative approach to preventing and managing obesity.

"Determining the precise role of inflammatory compounds in the d
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Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

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