Navigation Links
LSUHSC research finding keys to future obesity & related diseases
Date:12/6/2012

New Orleans, LA Melinda Sothern, PhD, CEP, Professor and Director of the Behavioral and Community Health Sciences Program at LSU Health Sciences Center New Orleans School of Public Health, has been awarded $675,000 in grant funding to advance her research on the role of social, genetic, environmental and behavioral determinants of future obesity. Five years later, Dr. Sothern is bringing back the same group of healthy children, now adolescents, in which she previously discovered early predictors of metabolic syndrome when they were 7-9 years old. The funding, from the National Institute on Minority Health and Health Disparities, is a sub-project in collaboration with the University of Alabama Birmingham.

"With soaring obesity rates and the earlier emergence of related conditions like type 2 diabetes, this type of research is critical," notes Dr. Melinda Sothern, principal investigator, one of the few scientists conducting cross-sectional studies of obesity in children and adolescents. "The identification of biomarkers at an early age may offer targets for diagnosis, treatment, and prevention."

Dr. Sothern previously documented evidence that supports relationships seen in adolescents between insulin sensitivity and fatty liver, belly fat, and total body fat and identified additional potential early markers of insulin resistance and metabolic syndrome in healthy 7-9 year-old children, including fat in muscle cells, blood pressure, physical activity, and birth weight. The study found that fat in the liver, abdominal fat, and fat oxidation predicted insulin resistance and appear to be early markers for the metabolic syndrome via a mechanism of impaired lipid metabolism and fat oxidation. Impaired metabolic function may be due, in part, to pre-and post natal factors that are modified by current physical activity. Therefore, race, low or high pregnancy weight and/or birth weight, and low physical activity collectively create a phenotype for poor metabolic function leading to increased risk for insulin resistance in young children.

"In order to fully capitalize on the wealth of data that we have successfully gathered and analyzed thus far, we feel it is essential that we establish a longitudinal group," says Dr. Sothern. "This will enable us to examine prospectively the development of obesity and metabolic dysfunction and its relationship to inflammation from puberty to adolescence in healthy, non-obese and obese children."

In the current research project, Dr. Sothern will be re-measuring BMI and also analyzing blood tests for metabolic and genetic parameters in 100 healthy obese and non-obese adolescents. Because obesity and the metabolic syndrome are associated with inflammation, Dr. Sothern's group will examine the role of genetically determined pro and anti-inflammatory compounds and the change in obesity and biomarkers from pre-adolescence to adolescence. Over the same period of time, they will also examine the contribution of social determinants such as stress, economic disadvantage, neighborhood deterioration, violence, diet, and physical activity environment that can modify these compounds. The researchers will factor in maternal pregnancy weight and whether or not participants were breast-fed and for how long, as well.

To date no studies have documented the progression of obesity, insulin resistance and inflammation through the pubertal period of development using objective measures in relation to molecular, social and behavioral determinants of health in multi-ethnic children and adolescents.

Correlating the molecular basis of the metabolic syndrome in developing children with the social determinants of health such as maternal stress, neighborhood deterioration, food and physical activity environment and behavioral factors, diet and exercise, is an innovative approach to preventing and managing obesity.

"Determining the precise role of inflammatory compounds in the development of future obesity-related metabolic diseases will allow us to define a genetic profile in children at risk, which could be used to tailor interventions for cardio-metabolic disease," concludes Dr. Sothern. "In addition, potential protective environmental and behavioral factors, such as increased access to fruits and vegetables after considering the confounding effects of maternal pregnancy weight, nutrition and physical activity could be targets for early intervention."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related medicine news :

1. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
2. LSUHSCs Tilton awarded prestigious Hower Award
3. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
4. NIH awards $20 million over 5 years to train next generation of global health researchers
5. Researchers develop a new cell and animal model of inflammatory breast cancer
6. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
7. Sexually abused boys at risk for more unsafe sex: UBC research
8. Researchers Find Gene Mutations That May Be a Key to Autism
9. Researchers find evidence of banned antibiotics in poultry products
10. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
11. Scientific session and new research highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... , ... February 05, 2016 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... poised to once again host, Swirl, A Wine Tasting Event at the La ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... PROSHRED franchises from across the country gathered at the La Valencia Hotel in ... performers. PROSHRED Chicago was named the year’s most outstanding franchise, walking away ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each ... longer to access the treadmills. It’s a predictable trend. After the excesses of November ... get in shape by joining gyms, starting new walking or running routines, or signing ...
(Date:2/5/2016)... ... ... Boar’s Head Brand®, one of the nation’s leading providers of premium delicatessen ... stress out of your party preparation – follow these easy, yet delicious recipes with ... game. , “The key to hosting a successful game-day party is creating a flavorful ...
(Date:2/5/2016)... ... , ... At its annual meeting held last week, the American Parkinson Disease ... of Directors. Mr. McDermott succeeds former APDA Chairman, Fred Greene. , "We are pleased ... APDA President and CEO. “Pat has tirelessly served APDA since 2001 when he was ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016   Bernstein Liebhard LLP today ... the United States District Court for the District of ... "Class") consisting of all persons or entities who purchased common ... INSY ) from March 3, 2015 through January 25, ... of its officers with violations of the Securities Exchange Act ...
(Date:2/4/2016)... Feb. 4, 2016 Summary Breast cancer, ... and the most common cancer in women worldwide, accounting ... exceedingly prevalent. The number of women diagnosed with breast ... the number of deaths has declined due to earlier ... has been revolutionized in the past four decades, especially ...
(Date:2/4/2016)... Feb. 4, 2016 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year.  Reported sales decreased 3% ... quarter. , Net earnings per diluted share as ... prior- year period.  Adjusted EPS was $4.65, an increase ...
Breaking Medicine Technology: