Navigation Links
LSUHSC research discovers new targets for treatment of invasive breast cancer
Date:8/19/2009

New Orleans, LA Research led by Suresh Alahari, PhD, Associate Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, has shown for the first time that a tiny piece of RNA appears to play a major role in the development of invasive breast cancer and identified a gene that appears to inhibit invasive breast cancer. The research is published in the August 21, 2009 issue of the Journal of Biological Chemistry.

The LSUHSC researchers are the first to demonstrate that miR-27b, a novel microRNA, not only inactivates the ST14 gene which they found suppresses the growth of breast tumor cells, but also that miR-27b stimulates the breast cancer to invade other cells.

MicroRNAs are a new class of small, single-stranded RNA molecules which play an important regulatory role in cell biology. They bind to target genes and decrease their function. MicroRNAs may act as oncogenes (a gene that contributes to cancer development) or tumor suppressors.

In this study working with a line of human breast cancer cells, Dr. Alahari's team found that aggressively invasive breast tumor cells contain a large quantity of miR-27b molecules, while normal cells do not. Further analysis revealed that miR-27b increases during cancer progression, in direct proportion to the decrease in function of the ST14 gene. They found that miR-27b promotes cell growth and cell invasion, suggesting that miR-27b acts as a breast cancer oncogene. They also found that ST14 inhibits both cell growth and cell invasion, suggesting that ST14 is a breast cancer tumor suppressor gene and that it may also serve as a marker for the early detection of breast cancer.

According to the American Cancer Society, an estimated 192,370 new cases of invasive breast cancer are expected to occur among women in the US during 2009; about 1,910 new cases are expected in men. Excluding cancers of the skin, breast cancer is the most frequently diagnosed cancer in women. An estimated 40,610 breast cancer deaths (40,170 women, 440 men) are expected in 2009. Breast cancer ranks second as a cause of cancer death in women (after lung cancer).

"We are in the process of confirming these results and these studies will reveal whether ST14 can reduce breast tumor growth in animals," notes Dr. Alahari, who is also a member of the LSUHSC Stanley S. Scott Cancer Center. "Blocking the miR-27b/ST14 interaction or rescuing ST14 function may be an effective therapeutic approach to advance breast cancer treatment."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related medicine news :

1. LSUHSC contributes to revealing targets to reduce racial disparity in prostate cancer deaths
2. LSUHSC research identifies enzyme that makes survival molecule for key vision cells
3. LSUHSC research finds single gene controls growth of some cancers
4. LSUHSC researchers first to document early signs for diabetes in kids as young as 7
5. LSUHSC dental researcher funded to develop better dental materials
6. LSUHSC research shows fish oil protects against diseases like Parkinsons
7. LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
8. LSUHSCs England leads development of new testing guidelines for common nerve disorder
9. LSUHSCs Dr. Xiao Cheng Wu co-authors annual report to the nation on cancer
10. LSUHSCs Fontham makes history
11. LSUHSC public health contributes to estimate of HPV-related cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... ... provider in the United States, today announced its partnership with financial technology company, ... , The foundation of the solution lies within Hyosung’s superior ATMs, assisted self-service ...
(Date:7/24/2017)... , ... July 24, 2017 , ... Engineers at the ... because it produces the same kind of electrical energy that the body uses. ... of moving electrons. This flow of electrons out of the battery is generated by ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... federal Substance Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted Response to ... Department of Health Care Services, will facilitate the development of a hub and ...
(Date:7/24/2017)... ... 2017 , ... Every year, thousands of dedicated Higher Education and K12 professionals ... is coupled with a dynamic theme like Camp Canvas; this year, they’ve managed to ... , To extend their partnership with Canvas beyond the LMS integration, Modo Labs ...
(Date:7/24/2017)... Solana Beach, California (PRWEB) , ... July 24, ... ... and commercialization of autologous fat (adipose) transfer systems announces the issuance of United ... (the ‘324 patent) for its adipose filtration technology. The '398 and '324 ...
Breaking Medicine News(10 mins):
(Date:7/24/2017)... 24, 2017 IBM (NYSE: IBM ) has ... for Solid-State Arrays (SSA) for the fourth year in a ... to Gartner, "Vendors in the Leaders quadrant have the highest ... A vendor in the Leaders quadrant has the market share, ... acceptance of new technologies. These vendors demonstrate a clear understanding ...
(Date:7/21/2017)... Did you know that PhRMA member companies invested $65.5 ... spending on brand medicines, generics and the supply chain account for ... just half of this (7 percent)? Or that the ... venture capital investments in high-growth biopharmaceutical startups? ... The biopharmaceutical ...
(Date:7/14/2017)... 14, 2017 Endo International plc (NASDAQ: ENDP ... 8, 2017.  Members of its senior management team will host a ... 8:30 a.m. ET. The dial-in number to access ... (678) 509-7598, and the passcode is 45397076. Please dial in 10 ... A replay of the call will be available ...
Breaking Medicine Technology: