Navigation Links
LSUHSC bird study finds key info about human speech-language development
Date:10/19/2013

New Orleans, LA A study led by Xiaoching Li, PhD, at the LSU Health Sciences Center New Orleans Neuroscience Center of Excellence, has shown for the first time how two tiny molecules regulate a gene implicated in speech and language impairments as well as autism disorders, and that social context of vocal behavior governs their function. The findings are published in the October 16, 2013 issue of The Journal of Neuroscience.

Speech and language impairments affect the lives of millions of people, but the underlying neural mechanisms are largely unknown and difficult to study in humans. Zebra finches learn to sing and use songs for social communications. Because the vocal learning process in birds has many similarities with speech and language development in humans, the zebra finch provides a useful model to study the neural mechanisms underlying speech and language in humans.

Mutations in the FOXP2 gene have been linked to speech and language deficits and in autism disorders. A current theory is that a precise amount of FOXP2 is required for the proper development of the neural circuits processing speech and language, so it is important to understand how the FOXP2 gene is regulated. In this study, the research team identified two microRNAs, or miRNAs, miR-9 and miR-140-5p that regulate the levels of FOXP2. (MicroRNAs are a new class of small RNA molecules that play an important regulatory role in cell biology. They prevent the production of a particular protein by binding to and destroying the messenger RNA that would have produced the protein.) The researchers showed that in the zebra finch brain, these miRNAs are expressed in a basal ganglia nucleus that is required for vocal learning, and their function is regulated during vocal learning. More intriguingly, the expression of these two miRNAs is also regulated by the social context of song behavior in males singing undirected songs.

"Because the FOXP2 gene and these two miRNAs are evolutionarily conserved, the insights we obtained from studying birds are highly relevant to speech and language in humans and related neural developmental disorders such as autism," notes Xiaoching Li, PhD,

LSUHSC Assistant Professor of Cell Biology and Anatomy as well as Neuroscience. "Understanding how miRNAs regulate FOXP2 may open many possibilities to influence speech and language development through genetic variations in miRNA genes, as well as behavioral and environmental factors."


'/>"/>

Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert

Related medicine news :

1. LSUHSC study reports racial/ethnic differences in young people with cancer
2. LA Tumor Registry at LSUHSC receives $1.3 million from NCI
3. LSUHSC Dental School awarded $1.8 million for HIV care and education
4. LSUHSC research adds new info to improve pediatric dental sedation
5. LSUHSCs Hollier one of few ever awarded coveted national lectureship
6. LSUHSC paper judged best of the year
7. 8th edition of LSUHSC facultys textbook published
8. LSUHSC research reveals Rx target for HPV, Hep C and related cancers
9. LSUHSC research discoveries shed light on common STI
10. LSUHSC research provides new drug target for Her-2 related breast cancer
11. LSUHSC research finding keys to future obesity & related diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... ... ... Founded as an independent institute in 1968, The Glenholme School devoted ... 2018, Glenholme will celebrate its first 50 years and set a course for the ... ponies, was generously donated by Jean White Van Sinderen to Devereux in 1968. The ...
(Date:9/26/2017)... ... September 26, 2017 , ... The Organizing ... and tactical plans for Pittcon 2018. As of July 1, Adrian C. Michael, ... his named vice president, Charles Gardner, (ChemImage Corporation) and selected chairs. ...
(Date:9/26/2017)... ... September 26, 2017 , ... “Childhood Memories of a ... draw readers back, and help them relive their own youth. “Childhood Memories of a ... operator in the US Navy for nine years. He received his BS from ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... Time out ... and a little boy's newfound understanding that even grownups make mistakes. “Time Out for ... Southwestern United States for her entire life and whose passion for children inspired her ...
(Date:9/25/2017)... ... September 25, 2017 , ... The Renal Support Network (RSN) is ... improved functionality and enhanced rich content focused on RSN’s mission to empower people who ... hopeful about their future. , Our unique website is loaded with hundreds of ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... SAN FRANCISCO , Sept. 12, 2017 /PRNewswire/ ... Lifecycle Management Solutions (VLMS), is pleased to announce ... as a member of its Board of Directors ... 2017. ValGenesis VLMS enables life science companies to ... eliminate the use of paper in this process. ...
(Date:9/7/2017)... 2017  Eli Lilly and Company (NYSE: ... operations to more efficiently focus resources on developing ... Global workforce reductions, including those from a U.S. ... approximately 3,500 positions. With the ... of approximately $500 million that will begin to ...
Breaking Medicine Technology: