Navigation Links
LOH analysis on 4q in sporadic colorectal carcinoma
Date:9/24/2008

Thirteen fluorescent labeled polymorphic microsatellite markers were analyzed in 83 cases of colorectal carcinoma and matched normal tissue DNA by polymerase chain reaction (PCR). PCR products were eletrophoresed on an ABI 377 DNA sequencer. Genescan 3.7 and Genotype 3.7 software were used for loss of heterozygosity (LOH) scanning and analysis. Compared with clinicopathological features, significant relationship was observed between LOH frequencies on D4S3018 locus. In tumor larger than 5 cm in diameter, LOH frequency was significantly higher than that less than 5 cm (56% vs13.79%, P = 0.01). On D4S1534 locus, LOH was significantly associated with liver metastasis (80% vs 17.25%, P = 0.012).

A research article to be published on September 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Zheng from Department of Abdomen Surgery Department, the Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, expressed that tumor suppressor genes may exist on 4q in sporadic colorectal carcinoma.

The classic mechanism of tumor suppressor gene (TSG) inactivation is described by two-hit modes in which one allele is mutated (or promoter hypermethylation or a small intragenic deletion) and the other allele is lost through a number of possible mechanisms, resulting in LOH at multiple loci. LOH is the most common molecular genetic alteration observed in human cancers. A great deal of evidence supported the presence of TSGs in the short arm of chromosome 4. Much less studies have been reported in colorectal cancer. By deletion dense markers mapping, they detected two obvious high frequency LOH regions (4q12-21.1 and 4q25-31.1). PTPN13 (4q21.3), Caspase3 (4q34) and caspase6 (4q24-35), T1A12/mac25 (4q12-13) genes are putative TSGs.

This is a report that describes the LOH events on 4q in sporadic CRC in Chinese patients, further studies will benefit from this paper. The data presented is clear and concise in the text.


'/>"/>

Contact: Jian-Xia Cheng
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
3. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
4. Takeda statement on ACTOS meta-analysis published in the Journal of the American Medical Association
5. Takeda Statement on ACTOS(R) (Pioglitazone HCl) Meta-Analysis Published in the Journal of the American Medical Association
6. Physical Therapist Provides Injury Analysis for Fantasy Football
7. Sanofi-Aventis renews licenses for Genomatix chip analysis pipeline
8. Meta-Analysis of Blood Phe Levels and Clinical Outcomes in PKU Published
9. OCS and Press Ganey Partner to Create Joint Analysis of Outcomes and Satisfaction
10. New Analysis Underscores Legality of Physician Ranking and Public Reporting Systems When Used by Health Insurers to Improve Health Care Quality
11. Barta joins Conseco as Senior Vice President, Financial Planning & Analysis; Barra named Senior Vice President, Internal Audit; Clarke to head Investor Relations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... Maryland (PRWEB) , ... December 06, 2016 , ... ... announced the launch of a Kickstarter crowd funding campaign ( http://kck.st/2g3a1so ) for ... health active alerts and even taking an EKG from the watch while sharing ...
(Date:12/6/2016)... ... December 06, 2016 , ... 'Tis the season for ... routines. That means it's also the season when eating healthy, staying active, and taking ... on schedule is harder to do. , "Shopping trips, parties and family gatherings ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life Devoted ... of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted to ... for creative outlets, Carolyn gravitated toward writing through the inspiration of her aging ...
(Date:12/6/2016)... ... December 06, 2016 , ... TopConsumerReviews.com recently gave a best-in-class ... . , Mobility Scooters give freedom to people who need help getting around. For ... be facing a long period of rehabilitation after an illness or accident. There is ...
(Date:12/6/2016)... ... 06, 2016 , ... "Add realistic flares and light leaks to your media ... to clip with high quality 4K lens flare footage," said Christina Austin - CEO ... filmed on the RED Dragon. Utilizing the Dragon Sensor, TransFlare 4K Jewel lens flare ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... PARSIPPANY, N.J. , Dec. 5, ... Sankyo) today announced preliminary safety and efficacy data ... investigational oral selective MDM2 inhibitor, suggesting that DS-3032 ... including relapsed/refractory acute myeloid leukemia (AML) and high-risk ... escalation part of the phase 1 study of DS-3032 ...
(Date:12/5/2016)... -- BD (Becton, Dickinson and Company) (NYSE: BDX ... an enhanced technology platform designed with the ability to ... Pyxis™ and Alaris™ systems, at this year,s American ... being held in Las Vegas ... that approximately 68 percent of medication errors occur during ...
(Date:12/5/2016)... Eisai Inc. announced today new analyses and ... of the American Epilepsy Society (AES). ... adjunctive therapy for the treatment of partial onset seizures ... generalized tonic-clonic seizures (PGTC) in patients with epilepsy who ... Important Safety Information for FYCOMPA, including Boxed WARNING for ...
Breaking Medicine Technology: