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LJI develops new approach to identify genes poised to respond in asthma patients
Date:7/8/2014

d has remained focused on just a few molecules for discovery of new asthma treatments. Using their approach, Vijayanand's team searched the 1,500 targets for those that have the greatest likelihood of contributing to asthmatic disease. "Our unbiased and hypothesis-free approach has revealed a staggering but manageable number of new molecules that could play a role in asthma, and thus are potentially novel therapeutic targets," said Vijayanand.

Vijayanand and his team completed the study using different amounts of cells from the blood of healthy individuals and asthmatic patients. They did so in order to determine the smallest number of cells that were required for their technique, and found that it works with as little as 10,000 cells, which is significantly less than the millions of cells required to use other methods. Vijayanand envisions using this technique in situations where access to cells is limited, such as tumor biopsy for cancer.

The frequency of asthma is rising across the developed world as well as in several large developing countries. Treatment for asthma usually includes long-term nonspecific medication, as there is no cure at present.

Vijayanand says this study provides information that can be the starting point for many avenues of research and treatment. He says, "our study provides a rich and comprehensive resource that will be useful to the scientific community, enabling investigators to conduct their own detailed studies of the functional significance of the novel genes and enhancers that we have identified."


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Contact: Daniel Moyer
dmoyer@liai.org
858-752-6535
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

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