Navigation Links
LJI develops new approach to identify genes poised to respond in asthma patients
Date:7/8/2014

SAN DIEGO July 8, 2014 In a study published yesterday in the scientific journal Nature Immunology, a group at the La Jolla Institute (LJI) led by Pandurangan Vijayanand, Ph.D. identify new genes that likely contribute to asthma, a disease that currently affects over 200 million people world wide.

An organism's genetic material, also known as its genome, can be divided into small sections or 'neighborhoods.' Scientists can determine which genetic neighborhoods in a cell are active, or primed for gene production, by looking for a marker on the genome called an enhancer. An enhancer can increase the production of genes in its immediate neighborhood. The goal of the published study is to find genes whose neighborhoods are active in diseased cells, but inactive in healthy cells. Genes that are in active neighborhoods in diseased cells are likely to contribute to disease, and can potentially be targeted with drug treatments.

In order to find genetic neighborhoods that are active in asthmatic disease, the scientists in Vijayanand's group focus their experiments on memory cells, which develop abnormally in asthma patients. Memory cells are responsible for quickly responding to foreign substances called antigens that the host has been exposed to previously. Air passage inflammation, which characterizes asthma, is mediated by an overactive response to inhaled antigens by memory cells.

By applying his technique in small populations of abnormal memory cells, Vijayanand highlights 33 genetic neighborhoods that are highly active in diseased cells, but inactive in healthy cells, shifting the focus of asthma research to specific genes that are located in these neighborhoods.

Genome-wide association studies (GWAS) that are less precise, have previously identified 1,500 potential target regions associated with asthmatic disease. According to Vijayanand, these targets are too numerous to study individually, and as a result, the field has remained focused on just a few molecules for discovery of new asthma treatments. Using their approach, Vijayanand's team searched the 1,500 targets for those that have the greatest likelihood of contributing to asthmatic disease. "Our unbiased and hypothesis-free approach has revealed a staggering but manageable number of new molecules that could play a role in asthma, and thus are potentially novel therapeutic targets," said Vijayanand.

Vijayanand and his team completed the study using different amounts of cells from the blood of healthy individuals and asthmatic patients. They did so in order to determine the smallest number of cells that were required for their technique, and found that it works with as little as 10,000 cells, which is significantly less than the millions of cells required to use other methods. Vijayanand envisions using this technique in situations where access to cells is limited, such as tumor biopsy for cancer.

The frequency of asthma is rising across the developed world as well as in several large developing countries. Treatment for asthma usually includes long-term nonspecific medication, as there is no cure at present.

Vijayanand says this study provides information that can be the starting point for many avenues of research and treatment. He says, "our study provides a rich and comprehensive resource that will be useful to the scientific community, enabling investigators to conduct their own detailed studies of the functional significance of the novel genes and enhancers that we have identified."


'/>"/>

Contact: Daniel Moyer
dmoyer@liai.org
858-752-6535
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Related medicine news :

1. KAIST develops TransWall, a transparent touchable display wall
2. Exploring how the nervous system develops
3. InventHelp Inventor Develops Physical-Therapy Equipment (LAX-452)
4. Inventor and InventHelp Client Develops Convenient Foot-Care Accessory (HLW-1194)
5. InventHelp Inventor Develops Infant Urine Collection Device (OCM-592)
6. InventHelp Inventor Develops Hemorrhoid Relief Kit (HTM-3000)
7. Inventors from InventHelp Develops Improved Hot/Cold Pack (AUP-327)
8. InventHelp Inventor Develops Blood-Pressure Testing Accessory (LAX-437)
9. Inventor and InventHelp Client Develops Inconspicuous Hearing Aids (FED-1269)
10. InventHelp Inventor Develops Improved Wheelchair (CBA-2287)
11. InventHelp Inventor Develops Alternative to Steps (BGF-683)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... system that we intend to develop to enable prevention of a major side ... severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Fla. , Oct. 2, 2017  AllianceRx Walgreens ... company formed by Walgreens and pharmacy benefit manager Prime ... its new brand, which included the unveiling of new ... , as well as at a few other ... the new brand to patients, some of whom will ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
(Date:9/28/2017)... Sept. 28, 2017 Cohen Veterans Bioscience and ... use of wearable and home sensors for real-time monitoring ... Signal Foundation, a nonprofit organization focused on disruptive health ... an affordable analytical system to record and integrate behavioral, ... ...
Breaking Medicine Technology: