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LIALDA demonstrates prolonged release of mesalamine in an in vitro study using a simulated colon
Date:10/17/2007

f TIM, 78.01 percent of the 5-ASA was released from LIALDA in a fasted state and 68.49 percent in fed state. The remaining 11.64 percent (fasted state) and 13 percent (fed state) were recovered in the simulated colon residue. The apparent difference in recovery rates is minor in both simulated fasted and fed states as the results still show the continuing presence of high concentrations of 5-ASA in the colon. After an initial lag of about 23 hours, 5-ASA was released in the simulated colon consistently over approximately 20 hours. Analysis of the rate of 5-ASA release showed an initial linear increase that peaked at 67.5mg/hour within 56 hours in the simulated fed state and at 73.3mg/hour within 68 hours in the simulated fasted state.

Clinical relevance of in vitro data is unknown.


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