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LIALDA demonstrates prolonged release of mesalamine in an in vitro study using a simulated colon
Date:10/17/2007

Philadelphia, PA October 17, 2007 According to a study using a dynamic in vitro gastrointestinal tract system, Shire plc's (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) ulcerative colitis drug LIALDA (mesalamine) demonstrated a delivery system where the majority of the drugs active ingredient, 5-aminosalicyclic acid (5-ASA), is released over a prolonged period in the simulated colon. The colon is the site of inflammation in ulcerative colitis. In this in vitro model, after the LIALDA tablet passed through the simulated stomach, small intestine and colon compartments, the majority of 5-ASA within each tablet was released in the simulated colon (nearly 90 percent in simulated fasted state and 81 percent in the simulated fed state). Less than 1 percent of the 5-ASA was released from the tablet in the simulated stomach and small intestine. The study used the TNO Gastrointestinal Model, or TIM, which simulates a human stomach, small intestine and colon. The findings were published in the July/August issue of Advances in Therapy.

To our knowledge, traditional, delayed-release 5-ASA formulations have no mechanism for prolonging the release of 5-ASA once the tablet enters the colon, which may lead to the majority of 5-ASA being released immediately upon entering the colon instead of in the areas most likely to be inflamed, said lead study investigator and Senior Director of Pharmaceutical Sciences at Shire, Srini Tenjarla, PhD. Using the TIM system, a well-known and widely used system that mimics the fate of ingested products in the human adult GI tract, we were able to demonstrate that LIALDA tablets provide maximum release of 5-ASA in a prolonged manner, with minimal formulation disintegration and release in the simulated small intestine.

The TIM system allowed us to observe that after exposure to the simulated stomach and small intestine and immediately prior to being introduced into the simulated colon compartment, the LIALDA tablets had a swollen appe
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Contact: Sarah McGee
smcgee@golinharris.com
312-729-4125
Shire plc
Source:Eurekalert

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