Navigation Links
LA BioMed researcher says 'unexpected' increase in cancer risk found
Date:3/4/2008

TORRANCE An increased cancer risk in post-menopausal women after they stopped taking combined hormone therapy was an unexpected finding in a study that will be reported in the March 5 edition of the Journal of the American Medical Association (JAMA), said Rowan T. Chlebowski, M.D., Ph.D., a Los Angeles Biomedical Research Institute (LA BioMed) lead investigator who contributed to the study.

This latest study reinforces the original finding that combined hormone therapy of estrogen plus progestin should not be taken for the purpose of reducing disease in post-menopausal women, Chlebowski said. These findings also reinforce the need for monitoring for cancer in women who have taken the combination of estrogen plus progestin.

Dr. Chlebowski is a medical oncologist who has led several prior reports focusing on hormone effects on malignancies, including breast and colorectal cancer. He was a member of the team of researchers, led by Gerardo Heiss, M.D., of the University of North Carolina, Chapel Hill, N.C., who authored the March 5 JAMA report on a follow-up study of post-menopausal women enrolled in the Womens Health Initiative. Dr. Chlebowski is available for comment for reporters seeking further insight into the studys findings.

About the Womens Health Initiative

The Womens Health Initiative (WHI) trial began in 1993 to measure the effect of estrogen plus progestin on reducing disease in post-menopausal women. It included 16,608 postmenopausal women and assessed whether conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) prevents heart disease and hip fractures and increases the risk of breast cancer.

The trial was stopped in 2002 when data indicated an increased risk of breast cancer and a failure to demonstrate an overall health benefit of the therapy. Further analysis showed that women taking the two hormones had higher risks of cardiovascular disease, coronary heart disease, stroke and venous thromboembolism and lower risks of fracture and colorectal cancer.

About the Follow-Up Study

After stopping intervention, WHI followed the trial participants using the same study protocol of semi-annual monitoring to identify and classify study outcomes, in order to evaluate the effects of stopping hormone therapy.

Post intervention information for the period July 8, 2002 to March 31, 2005 was available on 95% of the women. The JAMA article reports on health outcomes at three years after the intervention was stopped (mean of 2.4 years of follow-up).

In the three years after stopping hormone therapy women who previously used estrogen plus progestin no longer had an increased risk of cardiovascular disease (heart disease, stroke, and blood clots) compared with women on placebo.

The lower risk of colorectal cancer and fractures seen during the trial in women who previously used estrogen plus progestin disappeared after stopping the combined hormone therapy.

But the risk of all cancers combined in women who previously used estrogen plus progestin increased after stopping the intervention compared to those previously on placebo. This was due to increases in a variety of cancers, including lung cancer.

After stopping the hormone therapy, mortality from all causes was somewhat higher in women who previously used estrogen plus progestin compared with those taking a placebo.


'/>"/>

Contact: Laura Mecoy
Lmecoy@issuesmanagement.com
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Related medicine news :

1. LA BioMed study finds hormone therapy increases frequency of abnormal mammograms, breast biopsies
2. BioMed Realty Trust Joint Venture Enters Into New $245 Million Construction Loan and Extends Term of Existing Loan Facility
3. Dr. Inder Verma named recipient of 2008 Vilcek Prize in biomedical science
4. 7th Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Richard P. Lifton
5. Lung Cancer Alliance Urges Inclusion of $5 Billion for Biomedical Research in Economic Stimulus Package
6. BioMed Central bolsters radiology image collection
7. New nanotube findings by Stanford researchers give boost to potential biomedical applications
8. American Red Cross Announces New Leader for Biomedical Services
9. XCPT(TM) Patient Engagement and Communication Software Signs Representation Agreement with Lifecore Biomedical, Inc. (Nasdaq: LCBM)
10. BioMed Realty Trust Declares Fourth Quarter 2007 Common Stock and Preferred Stock Dividends
11. LA BioMed researchers find few emergency rooms fully equipped for pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Regular gym ... find themselves having to wait longer to access the treadmills. It’s a predictable trend. ... resolutions to lose weight and get in shape by joining gyms, starting new walking ...
(Date:2/5/2016)... ... ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure Dental Health ... in need. The event is scheduled to take place on February 27, 2016 from ... dental care to community members in need. Each patient will be given the opportunity ...
(Date:2/5/2016)... ... February 05, 2016 , ... Health and wellness is a ... individuals in the event they are experiencing an illness. Migraines are a severe form ... are afflicted with migraines would not wish the pain on their worst enemy, the ...
(Date:2/5/2016)... ... 2016 , ... –This week, Atascadero water heater company First Call Plumbing ... To view the report, click here or see below. , There ... pros and cons, the type chosen is almost entirely up to personal preference. However, ...
(Date:2/4/2016)... ... February 04, 2016 , ... American Addiction Centers ... the start of Project HoldSpace. Through the partnership, the two organizations seek to ... youth between the ages of 13 and 18. Currently focused on Ohio schools, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016  Patients in Alabama seeking ... therapy no longer have to travel out of state. ... Urology Centers of Alabama to provide a total ... qualifying patients. Alabama is ... of prostate cancer using many different modalities. They are the ...
(Date:2/5/2016)... 2016 --> ... that the global active pharmaceuticals ingredients (APIs) market stood ... reach US$185.9 bn by 2020. It is expected to ... 2020. The title of the report is "Active Pharmaceutical ... and by Therapeutic Area) - Global Industry Analysis, Size, ...
(Date:2/5/2016)... 2016 Site Profile: --> ... - The Speech Recognition People, announced their latest primary healthcare case ... care, reduce turnaround times and to save the practice money. ... since 2013 Challenge: --> ,- Wirral CCG ... - Six doctors ,- Wirral CCG ,- VoicePower client since 2013 ...
Breaking Medicine Technology: