Navigation Links
LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma

LOS ANGELES (June 25, 2012) With summer upon us, more and more people will be heading outdoors and may be putting themselves at risk for various skin conditions which can be caused by continued exposure in the sun. Kevin Bruhn, Ph.D., and Noah Craft, M.D., Ph.D. lead investigators at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) - are conducting a study that may help treat the most serious condition caused by prolonged sun exposure: skin cancer. The study will evaluate a novel immune-stimulating cream for treating melanoma, the deadliest form of skin cancer. Initial funding for this project was provided by a grant from Edison International.

Melanoma kills approximately 8,000 Americans each year, and is a growing health problem for low-income populations and ethnic minorities. Drs. Bruhn and Craft believe that melanoma can be successfully combated with treatments that harness the body's immune system. To this end, they have obtained promising results from studies of an immune-stimulating topical cream called Imiquimod. Evidence suggests that Imiquimod might be used to therapeutically treat and perhaps even cure melanomas, especially when used in conjunction with other treatments, such as surgery.

In this study, Drs. Bruhn and Craft are examining how Imiquimod combats melanoma tumors in individual patients at the genetic level. The study will enroll at least 12 untreated melanoma patients from the surrounding communities. The cream will be applied topically to localized skin areas where the tumors exist, and patients will return after two weeks of treatment with the cream to have their malignancies surgically removed. Patients' immunological responses to the treatment will then be assessed on a gene-by-gene level, using cutting-edge sequencing technologies. Drs. Bruhn and Craft are hoping that the knowledge gained from this study will help guide them and other researchers in their efforts to develop personalized immune therapy that saves people's lives.

In addition to the melanoma study, Drs. Bruhn and Craft suggest the following precautions be taken to help prevent skin cancer, which is the most common cancer.

1. It is critical to choose the right sunscreen and use it correctly. Choose at least SPF 30. But keep in mind that higher SPFs don't offer that much more protection. Don't use SPF 60 and think you can apply it half as frequently.

2. Make sure your sunscreen protects against UV-A and UV-B.

3. Don't skimp. Apply very liberally to every part of your body exposed to the sun.

4. Apply sunscreen often, at least every two hours, as it does wear off. You should apply more often if swimming or sweating.

5. Wear a hat, sunglasses, lip balm, and clothing wherever possible, especially between 10 a.m. 4 p.m., when the sun's rays are the strongest.

6. And remember, if you have any suspicious moles or spots especially if they change size, shape, or color, or have irregular edges or different colors, are painful, itchy, or oozing have them looked at by a dermatologist right away.


Contact: Diana Soltesz
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Related medicine news :

1. UMMS researcher Victor Ambros, Ph.D., named co-recipient of 2012 Janssen Award for Biomedical Research
2. UCSC physicist Alexander Sher named Pew Scholar in the Biomedical Sciences
3. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
4. LA BioMeds Dr. Patricia Dickson researching treatments for neurodegenerative disorders
5. LA BioMed receives Grand Challenges Explorations grant
6. Biomedical researchers receive Hartwell Foundation awards
7. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
8. Elinext Leverages Latest QR Code and NFC Technologies in Mobile App Development for Retailers, Manufacturers, Advertisers, and Real Estate Companies
9. MadgeTech, Inc. Develops Temperature Recorder for Harsh Environments
10. National Actos Attorneys File Lawsuit on Behalf of Louisiana Woman who Developed Bladder Cancer Allegedly Due to The Diabetes Drug Actos
11. AIUM and AUA guideline development leads to practice accreditation for urologic ultrasound
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Purdue University ... the Life Sciences Initiative aimed at enhancing Purdue’s life sciences research and graduate ... True” capital campaign. , The investment will result in cohesive efforts across several ...
(Date:10/13/2015)... , ... October 13, 2015 , ... Sir Grout of ... to the local Boston chapter of Ronald McDonald House Charities® (RMHC®). This donation was ... supported Sir Grout of Greater Boston since its inception. , “We believe strongly in ...
(Date:10/13/2015)... ... October 13, 2015 , ... Califia Farms , one ... the release of its limited edition holiday seasonal flavors: Almondmilk Holiday Nog, new ... the unique flavor combinations and delicious taste Califia Farms’ beverages are known for, ...
(Date:10/13/2015)... ... October 13, 2015 , ... According to an article published October ... women who successfully lose weight with a bariatric procedure are much less likely to ... article notes that anywhere from 40 to 50 percent of all endometrial cancer cases ...
(Date:10/13/2015)... ... October 13, 2015 , ... Symposium Chairman, Dr. Rod J. ... Dallas Cosmetic Symposium to be held March 2nd and 3rd, 2016. The annual meeting, ... plastic surgeons and cosmetic physicians from around the world. , Key topics at this ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Kay Elledge, M.D., an established ... College of Obstetrics and Gynecology (FACOG) for the ... the Genuine Self Medical Laser Center where she ... recognition of Breast Cancer Awareness Month , ... MonaLisa Touch treatments initiated in the ...
(Date:10/13/2015)... N.J. , Oct. 13, 2015  ContraVir ... the "Company"), a biopharmaceutical company focused on the ... announced the closing of its previously announced underwritten ... stock and warrants to purchase up to 3,000,000 ... fixed combined price to the public of $3.00. ...
(Date:10/13/2015)... Science Automation (DSA), a system integration and automation engineering firm, ... the United Kingdom (UK) as the ... . The decision to open the new office comes in ... in the medical device industry throughout the UK. ... had tremendous success over the last several years in product ...
Breaking Medicine Technology: