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Kosan Opens TIME-1 Pivotal Phase 3 Trial in Multiple Myeloma
Date:1/3/2008

ion in multiple myeloma, tanespimycin has also demonstrated potent antitumor activity and a high level of tolerability in patients with HER2-positive metastatic breast cancer. Data from an ongoing Phase 2 trial of tanespimycin plus trastuzumab (Herceptin(R)) were recently presented at the 2007 San Antonio Breast Cancer Symposium showing a 55% clinical benefit in patients who had failed trastuzumab therapy prior to entering the trial.

Kosan's second-generation Hsp90 inhibitor, alvespimycin, has demonstrated encouraging antitumor activity (42% clinical benefit) and tolerability combined with trastuzumab in a Phase 1 clinical trial in patients with refractory HER2-positive metastatic breast cancer, and in patients with refractory ovarian cancer who were progressing on standard chemotherapy (presented at the 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium). Kosan has expanded this Phase 1 trial to include the combination of alvespimycin plus trastuzumab and paclitaxel (Taxol(R)). In the first quarter 2008, Kosan plans to initiate a Phase 2 trial of alvespimycin as monotherapy in patients with HER2-positive metastatic breast cancer who have not previously been treated with trastuzumab.

Kosan's lead epothilone clinical candidate, KOS-1584, has demonstrated promising antitumor activity and tolerability in patients with solid tumors, including non-small cell lung, ovarian and pancreatic cancers. Kosan plans to initiate a Phase 2 trial of KOS-1584 in non-small cell lung cancer in the first quarter of 2008.

In addition to its lead programs in Hsp90 inhibition and epothilones, Kosan's motilin agonist, KOS-2187, licensed to Pfizer, is progressing in a Phase 1 trial as a potential treatment for gastroesophageal reflux disease (GERD) and other gastrointestinal disorders. In 2008, Kosan plans to file investigational new drug (IND) applications for its next-generation epothilone, KOS-1803, and its novel nuclear export inhibitor, KOS-24
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SOURCE Kosan Biosciences Incorporated
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