Navigation Links
Knowledge of genetics improves uncertain medication
Date:2/19/2009

Roughly 100,000 Swedes are under treatment with the blood-thinning drug Waran. Patients evince varying sensitivity to Waran, which makes the initiation of treatment a risky balancing act between hemorrhaging and clotting. Now researchers at Uppsala University have developed a model for calculating the appropriate dose before treatment starts. The study appears in the scientific publication New England Journal of Medicine.

Some 20 research teams in four regions of the world have joined together to study whether it is possible to determine the proper dosage of Waran before starting treatment. Data from 5,700 subjects undergoing treatment with Waran were collected from the four parts of the globe. Niclas Eriksson, a statistician at UCR Uppsala Clinical Research Center has developed a model for calculating the right dosage of Waran for individuals of European, African, and Asian origin.

"The findings show that with the aid of two genes, VKORC1 and CYP2C9, it is possible to predict what dosage patients will land at," says Niclas Eriksson.

"Almost half of patients have mutations that entail that they need a slightly lower dose than normal, and a small percentage need a much lower dose," says Mia Wadelius, a physician and researcher in clinical pharmacology, Uppsala University Hospital, who was in charge of collecting the data in Sweden.

The next step will be to test this method on patients in health care. This spring an American clinical test will get underway to study whether custom-tailored treatment increases the certainty in treating patients with Waran. Similar clinical testing will start this autumn in seven countries in Europe. A total of 3,000 patients who are starting treatment with blood-thinning medicines will be recruited. The Swedish part of the study will be directed by Mia Wadelius, and the Waran clinics in Uppsala and Skne will be participating. Patients will start either with a custom-tailored dosage or with the normal dosage and then be compared.

"Even patients receiving a tailored dose need regular tests of the blood's ability to coagulate, since diet and other medicines play a role, but it is our hope that the treatment will be both safer and more secure with tailored dosage," says Mia Wadelius.


'/>"/>

Contact: Mia Wadelius
Mia.Wadelius@medsci.uu.se
46-018-611-4945
Uppsala University
Source:Eurekalert

Related medicine news :

1. Survey reveals disparities in skin cancer knowledge, protection among high school students
2. Health Knowledge Empowers the Public
3. ER episode impacts viewers health knowledge and behavior
4. ER episode impacts viewers health knowledge and behavior
5. Eclipsys Knowledge-Based Charting Helps Health First Improve Patient-Care Outcomes
6. Americans Knowledge of Fats Growing But Still Insufficient
7. Gauging parent knowledge about teens substance use
8. Education program leads to lasting improvement of cancer knowledge in African Americans
9. HealthTek Software Solutions Licenses First DataBanks OrderView Med Knowledge Base(TM) to Streamline Medication Selection, Management and Reconciliation
10. Education program leads to lasting improvement of cancer knowledge in African-Americans
11. Final of EPSRCs 2007 Knowledge Transfer Challenge Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... Atlanta, GA (PRWEB) , ... August 16, 2017 , ... ... the new Inc. 5000. The company ranked #4429 on the newly released, 36th annual ... The list represents a unique look at the most successful companies within the American ...
(Date:8/16/2017)... ... 2017 , ... In 1987, McDaniel & Durrett, P.C., a ... this year, and they’re marking the milestone by undertaking a significant office makeover, ... , It stands to reason that, given the central importance of gynecology to ...
(Date:8/16/2017)... ... August 16, 2017 , ... QualDerm Partners , a ... today announced Cumberland Skin Surgery and Dermatology has joined the company ... in both Hermitage and Lebanon, Tennessee, provides comprehensive general dermatology and skin cancer ...
(Date:8/16/2017)... Island, NY (PRWEB) , ... August 16, 2017 , ... ... with IV starts and blood draws. By broadly deploying AccuVein devices, Maury Regional Medical ... takes much of the guesswork out of a needle stick and more importantly, helps ...
(Date:8/16/2017)... ... August 16, 2017 , ... Paul Vitenas, MD, ... Connolly 2017 Top Doctor. The annual list identifies the nation’s top physicians, in a ... has made it to the top of Castle Connolly’s coveted ranking. , Castle Connolly ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017 AccuGenomics, Inc., a diagnostic ... today announced that the company has provided an AccuKit ... North Carolina at Chapel Hill and to Qura Therapeutics ... characterize and quantify HIV reservoir and viral expression in ... The HIV Cure Center is a joint initiative between ...
(Date:8/14/2017)... and PETACH TIKVAH, Israel ... (NASDAQ: BCLI), a leading developer of adult stem cell ... second quarter ending June 30, 2017. ... of preparing for our pivotal Phase 3 trial to ... Lebovits , President and Chief Executive Officer of BrainStorm. ...
(Date:8/10/2017)... 10, 2017  Physical Rehabilitation Network (PRN), acquired the long-standing ... Lakewood, Colorado . The reputable clinic will continue to ... DPT with his staff of four clinicians. Lipkin received his ... brings over 10 years of experience with a strong background ... PT marks the 10th PRN clinic in and around the ...
Breaking Medicine Technology: